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Body size and risk of kidney stones.
J Am Soc Nephrol 1998; 9(9):1645-52JA

Abstract

A variety of factors influence the formation of calcium oxalate kidney stones, including gender, diet, and urinary excretion of calcium, oxalate, and uric acid. Several of these factors may be related to body size. Because men on average have a larger body size and a threefold higher lifetime risk of stone formation than women, body size may be an important risk factor for calcium oxalate stone formation. The association between body size (height, weight, and body mass index) and the risk of kidney stone formation was studied in two large cohorts: the Nurses' Health Study (NHS; n = 89,376 women) and the Health Professionals Follow-up Study (HPFS; n = 51,529 men). Information on body size, kidney stone formation, and other exposures of interest was obtained by mailed questionnaires. A total of 1078 incident cases of kidney stones in NHS during 14 yr of follow-up and a total of 956 cases in HPFS during 8 yr of follow-up were confirmed. In both cohorts, the prevalence of a stone disease history and the incidence of stone disease were directly associated with weight and body mass index. However, the magnitude of the associations was consistently greater among women. Specifically, the age-adjusted prevalence odds ratio for women with body mass index > or = 32 kg/m2 compared with 21 to 22.9 kg/m2 was 1.76 (95% confidence interval, 1.50 to 2.07), but 1.38 (95% confidence interval, 1.16 to 1.65) for the same comparison in men. For incident stone formation, the multivariate relative risks for the similar comparisons were 1.89 (1.51 to 2.36) for women and 1.19 (0.83 to 1.70) in men. Height was inversely associated with the prevalence of stone disease but was not associated with incident stone formation. These results suggest that body size is associated with the risk of stone formation and that the magnitude of risk varies by gender. Additional studies are necessary to determine whether a reduction in body weight decreases the risk of stone formation, particularly in women.

Authors+Show Affiliations

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9727373

Citation

Curhan, G C., et al. "Body Size and Risk of Kidney Stones." Journal of the American Society of Nephrology : JASN, vol. 9, no. 9, 1998, pp. 1645-52.
Curhan GC, Willett WC, Rimm EB, et al. Body size and risk of kidney stones. J Am Soc Nephrol. 1998;9(9):1645-52.
Curhan, G. C., Willett, W. C., Rimm, E. B., Speizer, F. E., & Stampfer, M. J. (1998). Body size and risk of kidney stones. Journal of the American Society of Nephrology : JASN, 9(9), pp. 1645-52.
Curhan GC, et al. Body Size and Risk of Kidney Stones. J Am Soc Nephrol. 1998;9(9):1645-52. PubMed PMID: 9727373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body size and risk of kidney stones. AU - Curhan,G C, AU - Willett,W C, AU - Rimm,E B, AU - Speizer,F E, AU - Stampfer,M J, PY - 1998/9/4/pubmed PY - 1998/9/4/medline PY - 1998/9/4/entrez SP - 1645 EP - 52 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 9 IS - 9 N2 - A variety of factors influence the formation of calcium oxalate kidney stones, including gender, diet, and urinary excretion of calcium, oxalate, and uric acid. Several of these factors may be related to body size. Because men on average have a larger body size and a threefold higher lifetime risk of stone formation than women, body size may be an important risk factor for calcium oxalate stone formation. The association between body size (height, weight, and body mass index) and the risk of kidney stone formation was studied in two large cohorts: the Nurses' Health Study (NHS; n = 89,376 women) and the Health Professionals Follow-up Study (HPFS; n = 51,529 men). Information on body size, kidney stone formation, and other exposures of interest was obtained by mailed questionnaires. A total of 1078 incident cases of kidney stones in NHS during 14 yr of follow-up and a total of 956 cases in HPFS during 8 yr of follow-up were confirmed. In both cohorts, the prevalence of a stone disease history and the incidence of stone disease were directly associated with weight and body mass index. However, the magnitude of the associations was consistently greater among women. Specifically, the age-adjusted prevalence odds ratio for women with body mass index > or = 32 kg/m2 compared with 21 to 22.9 kg/m2 was 1.76 (95% confidence interval, 1.50 to 2.07), but 1.38 (95% confidence interval, 1.16 to 1.65) for the same comparison in men. For incident stone formation, the multivariate relative risks for the similar comparisons were 1.89 (1.51 to 2.36) for women and 1.19 (0.83 to 1.70) in men. Height was inversely associated with the prevalence of stone disease but was not associated with incident stone formation. These results suggest that body size is associated with the risk of stone formation and that the magnitude of risk varies by gender. Additional studies are necessary to determine whether a reduction in body weight decreases the risk of stone formation, particularly in women. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/9727373/Body_size_and_risk_of_kidney_stones_ L2 - http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=9727373 DB - PRIME DP - Unbound Medicine ER -