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Microbial factors leading to recurrent upper respiratory tract infections.
Pediatr Infect Dis J. 1998 Aug; 17(8 Suppl):S62-7.PI

Abstract

The treatment or prophylaxis of upper respiratory tract infections such as otitis media, sinusitis and tonsillitis with penicillins can generate bacterial resistance caused by production of beta-lactamase or changes in the penicillin-binding proteins. This resistance can spread in the community even to untreated individuals. The prevalence of resistant organisms tends to increase in the winter months. Beta-lactamase-producing bacteria may interfere with the eradication of penicillin-susceptible organisms and may account for substantial numbers of therapeutic failures among cases of otitis media, sinusitis and tonsillitis. The presence of normal flora that possess interfering capabilities against potential pathogens is beneficial to the host. Such flora may enhance recovery and prevent infections of the tonsils by group A beta-hemolytic streptococci. Therapeutic use of antimicrobial agents that preserve the normal flora but overcome penicillin-susceptible or -resistant pathogens may enhance recovery from upper respiratory tract infections.

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Authors+Show Affiliations

Brook I
Department of Pediatrics, Georgetown University, Washington, DC, USA.

MeSH

ChildHumansOtitis MediaPenicillin ResistancePenicillinsPharyngitisRecurrenceRespiratory Tract InfectionsStreptococcal InfectionsTonsillitis

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9727652

Citation

Brook, I. "Microbial Factors Leading to Recurrent Upper Respiratory Tract Infections." The Pediatric Infectious Disease Journal, vol. 17, no. 8 Suppl, 1998, pp. S62-7.
Brook I. Microbial factors leading to recurrent upper respiratory tract infections. Pediatr Infect Dis J. 1998;17(8 Suppl):S62-7.
Brook, I. (1998). Microbial factors leading to recurrent upper respiratory tract infections. The Pediatric Infectious Disease Journal, 17(8 Suppl), S62-7.
Brook I. Microbial Factors Leading to Recurrent Upper Respiratory Tract Infections. Pediatr Infect Dis J. 1998;17(8 Suppl):S62-7. PubMed PMID: 9727652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial factors leading to recurrent upper respiratory tract infections. A1 - Brook,I, PY - 1998/9/4/pubmed PY - 1998/9/4/medline PY - 1998/9/4/entrez SP - S62 EP - 7 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 17 IS - 8 Suppl N2 - The treatment or prophylaxis of upper respiratory tract infections such as otitis media, sinusitis and tonsillitis with penicillins can generate bacterial resistance caused by production of beta-lactamase or changes in the penicillin-binding proteins. This resistance can spread in the community even to untreated individuals. The prevalence of resistant organisms tends to increase in the winter months. Beta-lactamase-producing bacteria may interfere with the eradication of penicillin-susceptible organisms and may account for substantial numbers of therapeutic failures among cases of otitis media, sinusitis and tonsillitis. The presence of normal flora that possess interfering capabilities against potential pathogens is beneficial to the host. Such flora may enhance recovery and prevent infections of the tonsils by group A beta-hemolytic streptococci. Therapeutic use of antimicrobial agents that preserve the normal flora but overcome penicillin-susceptible or -resistant pathogens may enhance recovery from upper respiratory tract infections. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/9727652/Microbial_factors_leading_to_recurrent_upper_respiratory_tract_infections_ L2 - https://doi.org/10.1097/00006454-199808001-00003 DB - PRIME DP - Unbound Medicine ER -