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Vitamin E in the treatment of tardive dyskinesia: a preliminary study over 7 months at different doses.
Int Clin Psychopharmacol 1998; 13(4):147-55IC

Abstract

Vitamin E has been suggested to be a promising new treatment for tardive dyskinesia. However, little is known about the optimum dose. Twenty patients with tardive dyskinesia whose medication had been unchanged for at least 1 month were selected and randomly divided into a treatment group with 11 patients and a control group with nine patients. The treatment group was started on 600 mg of vitamin E per day, and this dose was increased over the 7 months of the trial to 1600 mg per day. The medication for the control group was unchanged. Severity of tardive dyskinesia was rated on the Abnormal Involuntary Movement Scale. Patients in the treatment group initially showed a significant response to the lower dose of 600 mg per day. However, this improvement was not maintained and differences between the two groups reached significant levels only after the dose of vitamin E was increased to 1600 mg per day. At this dose, there was a significant and sustained reduction in the severity of tardive dyskinesia. The results suggest that vitamin E is of value in the treatment of tardive dyskinesia and that the optimum dose for treating tardive dyskinesia is 1600 mg per day. In addition, there may be a dose related therapeutic effect of Vitamin E in tardive dyskinesia.

Authors+Show Affiliations

Department of Psychiatry, School of Post Graduate Medicine, Keele University, Stoke on Trent, Staffordshire, UK. pca02@keele.ac.uk

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9727725

Citation

Sajjad, S H.. "Vitamin E in the Treatment of Tardive Dyskinesia: a Preliminary Study Over 7 Months at Different Doses." International Clinical Psychopharmacology, vol. 13, no. 4, 1998, pp. 147-55.
Sajjad SH. Vitamin E in the treatment of tardive dyskinesia: a preliminary study over 7 months at different doses. Int Clin Psychopharmacol. 1998;13(4):147-55.
Sajjad, S. H. (1998). Vitamin E in the treatment of tardive dyskinesia: a preliminary study over 7 months at different doses. International Clinical Psychopharmacology, 13(4), pp. 147-55.
Sajjad SH. Vitamin E in the Treatment of Tardive Dyskinesia: a Preliminary Study Over 7 Months at Different Doses. Int Clin Psychopharmacol. 1998;13(4):147-55. PubMed PMID: 9727725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E in the treatment of tardive dyskinesia: a preliminary study over 7 months at different doses. A1 - Sajjad,S H, PY - 1998/9/4/pubmed PY - 1998/9/4/medline PY - 1998/9/4/entrez SP - 147 EP - 55 JF - International clinical psychopharmacology JO - Int Clin Psychopharmacol VL - 13 IS - 4 N2 - Vitamin E has been suggested to be a promising new treatment for tardive dyskinesia. However, little is known about the optimum dose. Twenty patients with tardive dyskinesia whose medication had been unchanged for at least 1 month were selected and randomly divided into a treatment group with 11 patients and a control group with nine patients. The treatment group was started on 600 mg of vitamin E per day, and this dose was increased over the 7 months of the trial to 1600 mg per day. The medication for the control group was unchanged. Severity of tardive dyskinesia was rated on the Abnormal Involuntary Movement Scale. Patients in the treatment group initially showed a significant response to the lower dose of 600 mg per day. However, this improvement was not maintained and differences between the two groups reached significant levels only after the dose of vitamin E was increased to 1600 mg per day. At this dose, there was a significant and sustained reduction in the severity of tardive dyskinesia. The results suggest that vitamin E is of value in the treatment of tardive dyskinesia and that the optimum dose for treating tardive dyskinesia is 1600 mg per day. In addition, there may be a dose related therapeutic effect of Vitamin E in tardive dyskinesia. SN - 0268-1315 UR - https://www.unboundmedicine.com/medline/citation/9727725/Vitamin_E_in_the_treatment_of_tardive_dyskinesia:_a_preliminary_study_over_7_months_at_different_doses_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9727725.ui DB - PRIME DP - Unbound Medicine ER -