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Mometasone furoate decreases adhesion molecule expression in psoriasis.
Eur J Dermatol. 1998 Sep; 8(6):421-6.EJ

Abstract

The topical corticosteroids are widely used in the treatment of moderate psoriasis, because of their usefulness for reducing inflammation and controlling itching. The therapeutic effect of corticosteroids in different cutaneous inflammatory diseases may be partially explained by their varying ability to block in vitro the synthesis of different cytokines, which play a pivotal role in epidermal hyperproliferation and leukocyte recruitment into the skin. The purpose of the present investigation was to further elucidate the mode of action of mometasone furoate, a medium-high potency, topical corticosteroid, on adhesion molecules, cytokines and cytokine receptor expression in psoriatic skin. Using an immunohistochemical assessment, we examined lesional skin biopsies from ten psoriatic patients before treatment and after 1 and 3 weeks of therapy. The overexpression of alpha 2, alpha 3, alpha 6, and beta 1 integrins detected in the spinous layer of untreated psoriatic skin was significantly decreased after therapy in 8 out of 10 cases, characterized by only partial clinical remission. In the remaining patients, a disappearance of the above integrin reactivity paralleling the disappearance of psoriatic lesions was induced by the treatment. With the exception of GM-CSF, no or only marginal effects of mometasone furoate on the cytokine and cytokine receptor system were observed. A significant reduction of the positive immunostaining with anti-ICAM-1 and ICAM-2 monoclonal antibodies on dermal vascular endothelial cells was also seen. Thus, our findings indicate that the therapeutic effects of mometasone furoate in psoriasis are mediated principally by decreasing adhesion molecule expression and to a lesser degree by inhibiting cytokine synthesis.

Authors+Show Affiliations

Institute of Dermatological Science, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9729054

Citation

Berti, E, et al. "Mometasone Furoate Decreases Adhesion Molecule Expression in Psoriasis." European Journal of Dermatology : EJD, vol. 8, no. 6, 1998, pp. 421-6.
Berti E, Cerri A, Marzano AV, et al. Mometasone furoate decreases adhesion molecule expression in psoriasis. Eur J Dermatol. 1998;8(6):421-6.
Berti, E., Cerri, A., Marzano, A. V., Richelda, R., Bianchi, B., & Caputo, R. (1998). Mometasone furoate decreases adhesion molecule expression in psoriasis. European Journal of Dermatology : EJD, 8(6), 421-6.
Berti E, et al. Mometasone Furoate Decreases Adhesion Molecule Expression in Psoriasis. Eur J Dermatol. 1998;8(6):421-6. PubMed PMID: 9729054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mometasone furoate decreases adhesion molecule expression in psoriasis. AU - Berti,E, AU - Cerri,A, AU - Marzano,A V, AU - Richelda,R, AU - Bianchi,B, AU - Caputo,R, PY - 1998/9/5/pubmed PY - 1998/9/5/medline PY - 1998/9/5/entrez SP - 421 EP - 6 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 8 IS - 6 N2 - The topical corticosteroids are widely used in the treatment of moderate psoriasis, because of their usefulness for reducing inflammation and controlling itching. The therapeutic effect of corticosteroids in different cutaneous inflammatory diseases may be partially explained by their varying ability to block in vitro the synthesis of different cytokines, which play a pivotal role in epidermal hyperproliferation and leukocyte recruitment into the skin. The purpose of the present investigation was to further elucidate the mode of action of mometasone furoate, a medium-high potency, topical corticosteroid, on adhesion molecules, cytokines and cytokine receptor expression in psoriatic skin. Using an immunohistochemical assessment, we examined lesional skin biopsies from ten psoriatic patients before treatment and after 1 and 3 weeks of therapy. The overexpression of alpha 2, alpha 3, alpha 6, and beta 1 integrins detected in the spinous layer of untreated psoriatic skin was significantly decreased after therapy in 8 out of 10 cases, characterized by only partial clinical remission. In the remaining patients, a disappearance of the above integrin reactivity paralleling the disappearance of psoriatic lesions was induced by the treatment. With the exception of GM-CSF, no or only marginal effects of mometasone furoate on the cytokine and cytokine receptor system were observed. A significant reduction of the positive immunostaining with anti-ICAM-1 and ICAM-2 monoclonal antibodies on dermal vascular endothelial cells was also seen. Thus, our findings indicate that the therapeutic effects of mometasone furoate in psoriasis are mediated principally by decreasing adhesion molecule expression and to a lesser degree by inhibiting cytokine synthesis. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/9729054/Mometasone_furoate_decreases_adhesion_molecule_expression_in_psoriasis_ L2 - http://www.diseaseinfosearch.org/result/6059 DB - PRIME DP - Unbound Medicine ER -