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Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers.

Abstract

Efficacy and safety of a collagen-alginate topical wound dressing (FIBRACOL Collagen-Alginate Wound Dressing) in the treatment of diabetic foot ulcers was compared with that of regular gauze moistened with normal saline. Seventy-five patients with foot ulcers were assigned randomly in a 2:1 ratio to the collagen-alginate test dressing or the gauze dressing. At the end of the study, the mean percent reduction of the wound area was 80.6% +/- 6% in the collagen-alginate dressing group and 61.1% +/- 26% in the gauze dressing group (p = .4692). Thirty-nine (78%) patients treated with the collagen-alginate dressing achieved > or = 75% wound area reduction, compared with 15 (60%) of gauze-treated patients. Complete healing was achieved in 24 (48%) of the collagen-alginate dressing group and 9 (36%) of the gauze dressing group. Wound size, when averaged over the 8-week period and with the duration of the ulcer taken into account, was reduced significantly in the collagen-alginate dressing group, as compared with the gauze dressing group (df = 1, p = .0049). It is concluded that the collagen-alginate test dressing is as or more effective and safe as the currently used treatment.

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  • Authors+Show Affiliations

    ,

    Beth Israel Deaconsess Medical Center, Harvard Medical School, Boston, MA, USA.

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alginates
    Bandages
    Collagen
    Diabetic Foot
    Female
    Humans
    Male
    Middle Aged
    Sodium Chloride
    Wound Healing

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9729942

    Citation

    Donaghue, V M., et al. "Evaluation of a Collagen-alginate Wound Dressing in the Management of Diabetic Foot Ulcers." Advances in Wound Care : the Journal for Prevention and Healing, vol. 11, no. 3, 1998, pp. 114-9.
    Donaghue VM, Chrzan JS, Rosenblum BI, et al. Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers. Adv Wound Care. 1998;11(3):114-9.
    Donaghue, V. M., Chrzan, J. S., Rosenblum, B. I., Giurini, J. M., Habershaw, G. M., & Veves, A. (1998). Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers. Advances in Wound Care : the Journal for Prevention and Healing, 11(3), pp. 114-9.
    Donaghue VM, et al. Evaluation of a Collagen-alginate Wound Dressing in the Management of Diabetic Foot Ulcers. Adv Wound Care. 1998;11(3):114-9. PubMed PMID: 9729942.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers. AU - Donaghue,V M, AU - Chrzan,J S, AU - Rosenblum,B I, AU - Giurini,J M, AU - Habershaw,G M, AU - Veves,A, PY - 1998/9/8/pubmed PY - 1998/9/8/medline PY - 1998/9/8/entrez SP - 114 EP - 9 JF - Advances in wound care : the journal for prevention and healing JO - Adv Wound Care VL - 11 IS - 3 N2 - Efficacy and safety of a collagen-alginate topical wound dressing (FIBRACOL Collagen-Alginate Wound Dressing) in the treatment of diabetic foot ulcers was compared with that of regular gauze moistened with normal saline. Seventy-five patients with foot ulcers were assigned randomly in a 2:1 ratio to the collagen-alginate test dressing or the gauze dressing. At the end of the study, the mean percent reduction of the wound area was 80.6% +/- 6% in the collagen-alginate dressing group and 61.1% +/- 26% in the gauze dressing group (p = .4692). Thirty-nine (78%) patients treated with the collagen-alginate dressing achieved > or = 75% wound area reduction, compared with 15 (60%) of gauze-treated patients. Complete healing was achieved in 24 (48%) of the collagen-alginate dressing group and 9 (36%) of the gauze dressing group. Wound size, when averaged over the 8-week period and with the duration of the ulcer taken into account, was reduced significantly in the collagen-alginate dressing group, as compared with the gauze dressing group (df = 1, p = .0049). It is concluded that the collagen-alginate test dressing is as or more effective and safe as the currently used treatment. SN - 1076-2191 UR - https://www.unboundmedicine.com/medline/citation/9729942/Evaluation_of_a_collagen_alginate_wound_dressing_in_the_management_of_diabetic_foot_ulcers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9729942.ui DB - PRIME DP - Unbound Medicine ER -