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Liver problems in pregnancy: part 2--managing pre-existing and pregnancy-induced liver disease.
Medscape Womens Health. 1998 Mar; 3(2):2.MW

Abstract

In distinguishing normal from abnormal hepatic changes, the author described the expected changes in liver tests that occur during complicated pregnancy. This article reviews the forms of pre-existing liver disease that may affect or be affected by pregnancy, as well as liver diseases that tend to arise during pregnancy. Among the pre-existing liver diseases are autoimmune chronic active hepatitis, which may be activated by pregnancy and tends to be associated with an increased risk of still and premature births. Worsening of chronic hepatitis B and C has occasionally been observed. While some women with cirrhosis can sustain a normal pregnancy without any worsening of hepatic function, others develop liver failure; plus, women with cirrhosis are less fertile and have higher rates of both stillbirths and premature infants. Other liver disorders that may or may not be affected by pregnancy include Dubin-Johnson syndrome, Gilbert syndrome, benign recurrent intrahepatic cholestasis, Wilson's disease, hepatic adenomas, and focal nodular hyperplasia. Among the hepatic disorders that occur during pregnancy in normally healthy women and then resolve after delivery is intrahepatic cholestasis of pregnancy (also known as pruritus gravidarum, recurrent intrahepatic cholestasis of pregnancy, and obstetric hepatosis). Others include acute fatty liver of pregnancy and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count), which may be part of the spectrum of disorders associated with pre-eclampsia/eclampsia. Pregnancy may also trigger the dissemination of herpes infection to the liver.

Authors+Show Affiliations

University of Colorado Health Sciences Center, Denver, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9732096

Citation

Everson, G T.. "Liver Problems in Pregnancy: Part 2--managing Pre-existing and Pregnancy-induced Liver Disease." Medscape Women's Health, vol. 3, no. 2, 1998, p. 2.
Everson GT. Liver problems in pregnancy: part 2--managing pre-existing and pregnancy-induced liver disease. Medscape Womens Health. 1998;3(2):2.
Everson, G. T. (1998). Liver problems in pregnancy: part 2--managing pre-existing and pregnancy-induced liver disease. Medscape Women's Health, 3(2), 2.
Everson GT. Liver Problems in Pregnancy: Part 2--managing Pre-existing and Pregnancy-induced Liver Disease. Medscape Womens Health. 1998;3(2):2. PubMed PMID: 9732096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver problems in pregnancy: part 2--managing pre-existing and pregnancy-induced liver disease. A1 - Everson,G T, PY - 1998/9/10/pubmed PY - 1998/9/10/medline PY - 1998/9/10/entrez SP - 2 EP - 2 JF - Medscape women's health JO - Medscape Womens Health VL - 3 IS - 2 N2 - In distinguishing normal from abnormal hepatic changes, the author described the expected changes in liver tests that occur during complicated pregnancy. This article reviews the forms of pre-existing liver disease that may affect or be affected by pregnancy, as well as liver diseases that tend to arise during pregnancy. Among the pre-existing liver diseases are autoimmune chronic active hepatitis, which may be activated by pregnancy and tends to be associated with an increased risk of still and premature births. Worsening of chronic hepatitis B and C has occasionally been observed. While some women with cirrhosis can sustain a normal pregnancy without any worsening of hepatic function, others develop liver failure; plus, women with cirrhosis are less fertile and have higher rates of both stillbirths and premature infants. Other liver disorders that may or may not be affected by pregnancy include Dubin-Johnson syndrome, Gilbert syndrome, benign recurrent intrahepatic cholestasis, Wilson's disease, hepatic adenomas, and focal nodular hyperplasia. Among the hepatic disorders that occur during pregnancy in normally healthy women and then resolve after delivery is intrahepatic cholestasis of pregnancy (also known as pruritus gravidarum, recurrent intrahepatic cholestasis of pregnancy, and obstetric hepatosis). Others include acute fatty liver of pregnancy and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count), which may be part of the spectrum of disorders associated with pre-eclampsia/eclampsia. Pregnancy may also trigger the dissemination of herpes infection to the liver. SN - 1521-2076 UR - https://www.unboundmedicine.com/medline/citation/9732096/Liver_problems_in_pregnancy:_part_2__managing_pre_existing_and_pregnancy_induced_liver_disease_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -