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Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole.
Am J Clin Nutr 1998; 68(3):699-704AJ

Abstract

Subjects taking a hydrogen pump blocking agent (omeprazole) develop bacterial overgrowth of the small intestine. We tested the hypothesis that this bacterial overgrowth produces menaquinones, which would meet the vitamin requirement in situations of vitamin K deficiency. In a crossover-type design, 13 healthy volunteers eating a phylloquinone-restricted diet for 35 d were randomly assigned to take omeprazole during the first period of study or starting on day 15 until the end of the study. Coagulation times, serum osteocalcin [total osteocalcin and undercarboxylated osteocalcin (ucOC)], plasma phylloquinone, urinary gamma-carboxyglutamic acid, and plasma undercarboxylated prothrombin (PIVKA-II) were measured. Plasma phylloquinone concentrations declined 82% with dietary phylloquinone restriction (P < 0.05) and were not significantly different in the period when the diet was combined with omeprazole treatment (P > 0.05). The mean value for PIVKA-II during the phylloquinone-restricted diet significantly increased 5.7-fold from baseline (P < 0.05); however, the combination of omeprazole treatment and the phylloquinone-restricted diet significantly reduced PIVKA-II values by 21% (P < 0.05) compared with the diet period alone. There were no alterations in total or percentage ucOC concentrations during the phylloquinone-restricted diet or during the period of diet plus omeprazole treatment. Our data support the hypothesis that bacterial overgrowth results in the synthesis and absorption of menaquinones. These menaquinones contribute to vitamin K nutriture during dietary phylloquinone restriction, but not enough to restore normal vitamin K status.

Authors+Show Affiliations

Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9734750

Citation

Paiva, S A., et al. "Interaction Between Vitamin K Nutriture and Bacterial Overgrowth in Hypochlorhydria Induced By Omeprazole." The American Journal of Clinical Nutrition, vol. 68, no. 3, 1998, pp. 699-704.
Paiva SA, Sepe TE, Booth SL, et al. Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. Am J Clin Nutr. 1998;68(3):699-704.
Paiva, S. A., Sepe, T. E., Booth, S. L., Camilo, M. E., O'Brien, M. E., Davidson, K. W., ... Russell, R. M. (1998). Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. The American Journal of Clinical Nutrition, 68(3), pp. 699-704.
Paiva SA, et al. Interaction Between Vitamin K Nutriture and Bacterial Overgrowth in Hypochlorhydria Induced By Omeprazole. Am J Clin Nutr. 1998;68(3):699-704. PubMed PMID: 9734750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. AU - Paiva,S A, AU - Sepe,T E, AU - Booth,S L, AU - Camilo,M E, AU - O'Brien,M E, AU - Davidson,K W, AU - Sadowski,J A, AU - Russell,R M, PY - 1998/9/12/pubmed PY - 1998/9/12/medline PY - 1998/9/12/entrez SP - 699 EP - 704 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 3 N2 - Subjects taking a hydrogen pump blocking agent (omeprazole) develop bacterial overgrowth of the small intestine. We tested the hypothesis that this bacterial overgrowth produces menaquinones, which would meet the vitamin requirement in situations of vitamin K deficiency. In a crossover-type design, 13 healthy volunteers eating a phylloquinone-restricted diet for 35 d were randomly assigned to take omeprazole during the first period of study or starting on day 15 until the end of the study. Coagulation times, serum osteocalcin [total osteocalcin and undercarboxylated osteocalcin (ucOC)], plasma phylloquinone, urinary gamma-carboxyglutamic acid, and plasma undercarboxylated prothrombin (PIVKA-II) were measured. Plasma phylloquinone concentrations declined 82% with dietary phylloquinone restriction (P < 0.05) and were not significantly different in the period when the diet was combined with omeprazole treatment (P > 0.05). The mean value for PIVKA-II during the phylloquinone-restricted diet significantly increased 5.7-fold from baseline (P < 0.05); however, the combination of omeprazole treatment and the phylloquinone-restricted diet significantly reduced PIVKA-II values by 21% (P < 0.05) compared with the diet period alone. There were no alterations in total or percentage ucOC concentrations during the phylloquinone-restricted diet or during the period of diet plus omeprazole treatment. Our data support the hypothesis that bacterial overgrowth results in the synthesis and absorption of menaquinones. These menaquinones contribute to vitamin K nutriture during dietary phylloquinone restriction, but not enough to restore normal vitamin K status. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9734750/Interaction_between_vitamin_K_nutriture_and_bacterial_overgrowth_in_hypochlorhydria_induced_by_omeprazole_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.3.699 DB - PRIME DP - Unbound Medicine ER -