Tags

Type your tag names separated by a space and hit enter

Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma.
Lancet 1998; 352(9130):772-6Lct

Abstract

BACKGROUND

Infections are an important cause of morbidity and mortality in patients with multiple trauma. Studies in both animals and human beings have suggested that glutamine-enriched nutrition decreases the number of infections.

METHODS

Patients with multiple trauma with an expected survival of more than 48 h, and who had an Injury Severity Score of 20 or more, were randomly allocated glutamine supplemented enteral nutrition or a balanced, isonitrogenous, isocaloric enteral-feeding regimen along with usual care. Each patient was assessed every 8 h for infection, the primary endpoint. Data were analysed both per protocol, which included enteral feeding for at least 5 days, and by intention to treat.

FINDINGS

72 patients were enrolled and 60 received enteral feeding (29 glutamine-supplemented) for at least 5 days. Five (17%) of 29 patients in the glutamine-supplemented group had pneumonia compared with 14 (45%) of 31 patients in the control group (p<0.02). Bacteraemia occurred in two (7%) patients in glutamine group and 13 (42%) in the control group (p<0.005). One patient in the glutamine group had sepsis compared with eight (26%) patients in the control group (p<0.02).

INTERPRETATION

There was a low frequency of pneumonia, sepsis, and bacteraemia in patients with multiple trauma who received glutamine-supplemented enteral nutrition. Larger studies are needed to investigate whether glutamine-supplemented enteral nutrition reduces mortality.

Authors+Show Affiliations

Department of Surgery, Free University Hospital, Amsterdam, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9737282

Citation

Houdijk, A P., et al. "Randomised Trial of Glutamine-enriched Enteral Nutrition On Infectious Morbidity in Patients With Multiple Trauma." Lancet (London, England), vol. 352, no. 9130, 1998, pp. 772-6.
Houdijk AP, Rijnsburger ER, Jansen J, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998;352(9130):772-6.
Houdijk, A. P., Rijnsburger, E. R., Jansen, J., Wesdorp, R. I., Weiss, J. K., McCamish, M. A., ... van Leeuwen, P. A. (1998). Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet (London, England), 352(9130), pp. 772-6.
Houdijk AP, et al. Randomised Trial of Glutamine-enriched Enteral Nutrition On Infectious Morbidity in Patients With Multiple Trauma. Lancet. 1998 Sep 5;352(9130):772-6. PubMed PMID: 9737282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. AU - Houdijk,A P, AU - Rijnsburger,E R, AU - Jansen,J, AU - Wesdorp,R I, AU - Weiss,J K, AU - McCamish,M A, AU - Teerlink,T, AU - Meuwissen,S G, AU - Haarman,H J, AU - Thijs,L G, AU - van Leeuwen,P A, PY - 1998/9/16/pubmed PY - 1998/9/16/medline PY - 1998/9/16/entrez SP - 772 EP - 6 JF - Lancet (London, England) JO - Lancet VL - 352 IS - 9130 N2 - BACKGROUND: Infections are an important cause of morbidity and mortality in patients with multiple trauma. Studies in both animals and human beings have suggested that glutamine-enriched nutrition decreases the number of infections. METHODS: Patients with multiple trauma with an expected survival of more than 48 h, and who had an Injury Severity Score of 20 or more, were randomly allocated glutamine supplemented enteral nutrition or a balanced, isonitrogenous, isocaloric enteral-feeding regimen along with usual care. Each patient was assessed every 8 h for infection, the primary endpoint. Data were analysed both per protocol, which included enteral feeding for at least 5 days, and by intention to treat. FINDINGS: 72 patients were enrolled and 60 received enteral feeding (29 glutamine-supplemented) for at least 5 days. Five (17%) of 29 patients in the glutamine-supplemented group had pneumonia compared with 14 (45%) of 31 patients in the control group (p<0.02). Bacteraemia occurred in two (7%) patients in glutamine group and 13 (42%) in the control group (p<0.005). One patient in the glutamine group had sepsis compared with eight (26%) patients in the control group (p<0.02). INTERPRETATION: There was a low frequency of pneumonia, sepsis, and bacteraemia in patients with multiple trauma who received glutamine-supplemented enteral nutrition. Larger studies are needed to investigate whether glutamine-supplemented enteral nutrition reduces mortality. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/9737282/Randomised_trial_of_glutamine_enriched_enteral_nutrition_on_infectious_morbidity_in_patients_with_multiple_trauma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(98)02007-8 DB - PRIME DP - Unbound Medicine ER -