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A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal.
Southeast Asian J Trop Med Public Health. 1998 Mar; 29(1):154-8.SA

Abstract

Twenty-seven cases of Kala-azar were treated with sodium stibogluconate at a dose of 20 mg/kg/day for 20 days (group A) and an equal number of cases were treated with the same dose but for a longer duration of 30 days (group B). Clinical and laboratory evaluation of these cases were carried out before and after therapy, during a follow up of cases every month, upto 6 months. Renal and liver function tests and electrocardiography were carried out of monitor any toxic effect of the drug during therapy. The cure rates of patients were 77.78% and 92.59% in group A and B cases respectively. Six and two patients in group A and B respectively were unresponsive to the treatment and showed relapse. Results of the study show that treatment of cases of Kala-azar with sodium stibogluconate in a dosage of 20 mg/kg/day for a longer period of 30 days is effective with a higher cure rate and minimum side effects, for treatment of cases of Kala-azar in this eastern part of Nepal, endemic for the disease.

Authors+Show Affiliations

Karki P
Department of Medicine and Microbiology, BP Koirala, Institute of Health Sciences, Dharan, Nepal. bpkihs@npl.healthnet.org
Koirala S
No affiliation info available
Parija SC
No affiliation info available
Hansdak SG
No affiliation info available
Das ML
No affiliation info available

MeSH

AdolescentAdultAntimony Sodium GluconateAntiprotozoal AgentsChildFemaleHumansLeishmaniasis, VisceralMaleMiddle AgedNepal

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9740292

Citation

Karki, P, et al. "A Thirty Day Course of Sodium Stibogluconate for Treatment of Kala-azar in Nepal." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 29, no. 1, 1998, pp. 154-8.
Karki P, Koirala S, Parija SC, et al. A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal. Southeast Asian J Trop Med Public Health. 1998;29(1):154-8.
Karki, P., Koirala, S., Parija, S. C., Hansdak, S. G., & Das, M. L. (1998). A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal. The Southeast Asian Journal of Tropical Medicine and Public Health, 29(1), 154-8.
Karki P, et al. A Thirty Day Course of Sodium Stibogluconate for Treatment of Kala-azar in Nepal. Southeast Asian J Trop Med Public Health. 1998;29(1):154-8. PubMed PMID: 9740292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal. AU - Karki,P, AU - Koirala,S, AU - Parija,S C, AU - Hansdak,S G, AU - Das,M L, PY - 1998/9/18/pubmed PY - 1998/9/18/medline PY - 1998/9/18/entrez SP - 154 EP - 8 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 29 IS - 1 N2 - Twenty-seven cases of Kala-azar were treated with sodium stibogluconate at a dose of 20 mg/kg/day for 20 days (group A) and an equal number of cases were treated with the same dose but for a longer duration of 30 days (group B). Clinical and laboratory evaluation of these cases were carried out before and after therapy, during a follow up of cases every month, upto 6 months. Renal and liver function tests and electrocardiography were carried out of monitor any toxic effect of the drug during therapy. The cure rates of patients were 77.78% and 92.59% in group A and B cases respectively. Six and two patients in group A and B respectively were unresponsive to the treatment and showed relapse. Results of the study show that treatment of cases of Kala-azar with sodium stibogluconate in a dosage of 20 mg/kg/day for a longer period of 30 days is effective with a higher cure rate and minimum side effects, for treatment of cases of Kala-azar in this eastern part of Nepal, endemic for the disease. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/9740292/A_thirty_day_course_of_sodium_stibogluconate_for_treatment_of_Kala_azar_in_Nepal_ DB - PRIME DP - Unbound Medicine ER -