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A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain.
Brain Res. 1998 Aug 17; 802(1-2):19-26.BR

Abstract

Rats were injected with the cannabinoid receptor agonists delta 9-THC (5 mg/kg) or anandamide (20 mg/kg) and assessed for changes in body temperature and locomotor activity. Their brains were then examined for the expression of the immediate early gene c-fos. Similar reductions in body temperature and locomotor activity were seen with delta 9-THC and anandamide although there was evidence, in line with previous reports, to suggest a shorter duration of action of anandamide. delta 9-THC and anandamide caused equally high levels of c-fos expression in the paraventricular nucleus of the hypothalamus and the lateral septum. Both drugs also increased c-fos expression in the central nucleus of the amygdala although the effect was greater with delta 9-THC. Only delta 9-THC caused significant increases in c-fos expression in the nucleus accumbens and caudate-putamen. These differences may be linked to differential activation of cannabinoid receptor subtypes or to differences in efficacy in activating second messenger systems linked to cannabinoid receptors. These findings complement evidence of qualitative differences in the actions of anandamide and delta 9-THC emerging from tests of drug discrimination, cross-tolerance, conditioned place preference and anxiety.

Authors+Show Affiliations

Department of Psychology, University of Sydney, NSW, Australia. iain@psych.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9748483

Citation

McGregor, I S., et al. "A Comparison of Delta 9-THC and Anandamide Induced C-fos Expression in the Rat Forebrain." Brain Research, vol. 802, no. 1-2, 1998, pp. 19-26.
McGregor IS, Arnold JC, Weber MF, et al. A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. Brain Res. 1998;802(1-2):19-26.
McGregor, I. S., Arnold, J. C., Weber, M. F., Topple, A. N., & Hunt, G. E. (1998). A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. Brain Research, 802(1-2), 19-26.
McGregor IS, et al. A Comparison of Delta 9-THC and Anandamide Induced C-fos Expression in the Rat Forebrain. Brain Res. 1998 Aug 17;802(1-2):19-26. PubMed PMID: 9748483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. AU - McGregor,I S, AU - Arnold,J C, AU - Weber,M F, AU - Topple,A N, AU - Hunt,G E, PY - 1998/9/28/pubmed PY - 1998/9/28/medline PY - 1998/9/28/entrez SP - 19 EP - 26 JF - Brain research JO - Brain Res VL - 802 IS - 1-2 N2 - Rats were injected with the cannabinoid receptor agonists delta 9-THC (5 mg/kg) or anandamide (20 mg/kg) and assessed for changes in body temperature and locomotor activity. Their brains were then examined for the expression of the immediate early gene c-fos. Similar reductions in body temperature and locomotor activity were seen with delta 9-THC and anandamide although there was evidence, in line with previous reports, to suggest a shorter duration of action of anandamide. delta 9-THC and anandamide caused equally high levels of c-fos expression in the paraventricular nucleus of the hypothalamus and the lateral septum. Both drugs also increased c-fos expression in the central nucleus of the amygdala although the effect was greater with delta 9-THC. Only delta 9-THC caused significant increases in c-fos expression in the nucleus accumbens and caudate-putamen. These differences may be linked to differential activation of cannabinoid receptor subtypes or to differences in efficacy in activating second messenger systems linked to cannabinoid receptors. These findings complement evidence of qualitative differences in the actions of anandamide and delta 9-THC emerging from tests of drug discrimination, cross-tolerance, conditioned place preference and anxiety. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/9748483/A_comparison_of_delta_9_THC_and_anandamide_induced_c_fos_expression_in_the_rat_forebrain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(98)00549-6 DB - PRIME DP - Unbound Medicine ER -