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[Needle-like inclusions in liver cells are specific diagnostic signs of porphyria cutanea tarda].
Vnitr Lek 1998; 44(7):418-22VL

Abstract

Needle-shaped cytoplasmic liver cell inclusions are considered to represent a feature typical of porphyria cutanea tarda (PCT). Histological sections of 849 liver biopsies were stained with ferricyanide reduction reaction for demonstration of the inclusions. They were detected in 18 cases, and in all of them the diagnosis PCT was clinically and/or biochemically confirmed. In our group of patients, PCT was associated with alcoholic liver disease in three cases, with chronic hepatitis C in three cases and with hepatocellular carcinoma in two cases. In the liver with hepatocellular carcinoma, the inclusions were present only in non-neoplastic liver tissue, not in the tumourous tissue. No inclusions were found in the liver tissue of patients without clinical signs of PCT.

Authors+Show Affiliations

Siklův patologickoanatomický ústav LF UK.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

9748879

Citation

Fakan, F, et al. "[Needle-like Inclusions in Liver Cells Are Specific Diagnostic Signs of Porphyria Cutanea Tarda]." Vnitrni Lekarstvi, vol. 44, no. 7, 1998, pp. 418-22.
Fakan F, Chlumská A, Malina L. [Needle-like inclusions in liver cells are specific diagnostic signs of porphyria cutanea tarda]. Vnitr Lek. 1998;44(7):418-22.
Fakan, F., Chlumská, A., & Malina, L. (1998). [Needle-like inclusions in liver cells are specific diagnostic signs of porphyria cutanea tarda]. Vnitrni Lekarstvi, 44(7), pp. 418-22.
Fakan F, Chlumská A, Malina L. [Needle-like Inclusions in Liver Cells Are Specific Diagnostic Signs of Porphyria Cutanea Tarda]. Vnitr Lek. 1998;44(7):418-22. PubMed PMID: 9748879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Needle-like inclusions in liver cells are specific diagnostic signs of porphyria cutanea tarda]. AU - Fakan,F, AU - Chlumská,A, AU - Malina,L, PY - 1998/9/28/pubmed PY - 1998/9/28/medline PY - 1998/9/28/entrez SP - 418 EP - 22 JF - Vnitrni lekarstvi JO - Vnitr Lek VL - 44 IS - 7 N2 - Needle-shaped cytoplasmic liver cell inclusions are considered to represent a feature typical of porphyria cutanea tarda (PCT). Histological sections of 849 liver biopsies were stained with ferricyanide reduction reaction for demonstration of the inclusions. They were detected in 18 cases, and in all of them the diagnosis PCT was clinically and/or biochemically confirmed. In our group of patients, PCT was associated with alcoholic liver disease in three cases, with chronic hepatitis C in three cases and with hepatocellular carcinoma in two cases. In the liver with hepatocellular carcinoma, the inclusions were present only in non-neoplastic liver tissue, not in the tumourous tissue. No inclusions were found in the liver tissue of patients without clinical signs of PCT. SN - 0042-773X UR - https://www.unboundmedicine.com/medline/citation/9748879/[Needle_like_inclusions_in_liver_cells_are_specific_diagnostic_signs_of_porphyria_cutanea_tarda]_ L2 - http://www.diseaseinfosearch.org/result/5879 DB - PRIME DP - Unbound Medicine ER -