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Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy.
Ann Neurol. 1998 Sep; 44(3):408-10.AN

Abstract

IgM anti-myelin-associated glycoprotein (anti-MAG)/sulfated glucuronyl paragloboside (SGPG) antibody is found in some patients with chronic polyneuropathy (CP). An antigen-driven process is considered to induce this autoantibody, but the agent has yet to be identified. It has been reported that sera from cytomegalovirus (CMV)-infected patients contained anti-SGPG antibody. To clarify the mechanism of the production of the anti-MAG/SGPG antibody, we investigated CMV DNA in sera from 26 patients with IgM anti-MAG/SGPG antibody-positive CP. Twenty-three (88%) had CMV DNA. The positive frequency was significantly higher than the frequencies in sera from patients with IgM anti-MAG/SGPG-negative CP, the other disease controls, and the normal control subjects. There were no statistical differences in the frequencies of Epstein-Barr virus DNA between anti-MAG/SGPG-positive and anti-MAG/SGPG-negative CP and between anti-MAG/SGPG-positive CP and each disease control. Moreover, no herpes simplex virus 1 DNA was detected in the sera from patients with anti-MAG/SGPG-positive CP. The strong correlation of anti-MAG/SGPG-positive CP with the presence of serum CMV DNA suggests that CMV infection induces the IgM anti-MAG/SGPG antibody.

Authors+Show Affiliations

Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9749612

Citation

Yuki, N, et al. "Correlation Between Cytomegalovirus Infection and IgM anti-MAG/SGPG Antibody-associated Neuropathy." Annals of Neurology, vol. 44, no. 3, 1998, pp. 408-10.
Yuki N, Yamamoto T, Hirata K. Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy. Ann Neurol. 1998;44(3):408-10.
Yuki, N., Yamamoto, T., & Hirata, K. (1998). Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy. Annals of Neurology, 44(3), 408-10.
Yuki N, Yamamoto T, Hirata K. Correlation Between Cytomegalovirus Infection and IgM anti-MAG/SGPG Antibody-associated Neuropathy. Ann Neurol. 1998;44(3):408-10. PubMed PMID: 9749612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy. AU - Yuki,N, AU - Yamamoto,T, AU - Hirata,K, PY - 1998/9/28/pubmed PY - 2000/4/25/medline PY - 1998/9/28/entrez SP - 408 EP - 10 JF - Annals of neurology JO - Ann. Neurol. VL - 44 IS - 3 N2 - IgM anti-myelin-associated glycoprotein (anti-MAG)/sulfated glucuronyl paragloboside (SGPG) antibody is found in some patients with chronic polyneuropathy (CP). An antigen-driven process is considered to induce this autoantibody, but the agent has yet to be identified. It has been reported that sera from cytomegalovirus (CMV)-infected patients contained anti-SGPG antibody. To clarify the mechanism of the production of the anti-MAG/SGPG antibody, we investigated CMV DNA in sera from 26 patients with IgM anti-MAG/SGPG antibody-positive CP. Twenty-three (88%) had CMV DNA. The positive frequency was significantly higher than the frequencies in sera from patients with IgM anti-MAG/SGPG-negative CP, the other disease controls, and the normal control subjects. There were no statistical differences in the frequencies of Epstein-Barr virus DNA between anti-MAG/SGPG-positive and anti-MAG/SGPG-negative CP and between anti-MAG/SGPG-positive CP and each disease control. Moreover, no herpes simplex virus 1 DNA was detected in the sera from patients with anti-MAG/SGPG-positive CP. The strong correlation of anti-MAG/SGPG-positive CP with the presence of serum CMV DNA suggests that CMV infection induces the IgM anti-MAG/SGPG antibody. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/9749612/Correlation_between_cytomegalovirus_infection_and_IgM_anti_MAG/SGPG_antibody_associated_neuropathy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1998&volume=44&issue=3&spage=408 DB - PRIME DP - Unbound Medicine ER -