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Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease.
Ann Neurol 1998; 44(3):410-3AN

Abstract

Postmortem studies have associated Alzheimer's disease (AD) with regionally increased oxidative damage to brain. Lacking, however, is a specific marker of oxidative damage to brain that may be measured during life. We tested the hypothesis that cerebrospinal fluid (CSF) concentrations of F2-isoprostanes (F2-IsoPs), stable products of arachidonate peroxidation, are increased in CSF of AD patients. CSF from lateral ventricles (VF) was analyzed from 11 AD patients and 11 control subjects who participated in a rapid autopsy program. VF F2-IsoP concentrations were significantly elevated in AD patients compared with control subjects (72 +/- 7 vs 46 +/- 4 pg/ml) and were significantly linearly correlated with brain weight (-0.3 pg/ml/g, r2 = 0.32). These results suggest that quantification of CSF F2-IsoP concentrations may provide a useful biomarker of central nervous system oxidative damage in AD.

Authors+Show Affiliations

Department of Pathology, and Center for Molecular Neurosciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9749613

Citation

Montine, T J., et al. "Cerebrospinal Fluid F2-isoprostane Levels Are Increased in Alzheimer's Disease." Annals of Neurology, vol. 44, no. 3, 1998, pp. 410-3.
Montine TJ, Markesbery WR, Morrow JD, et al. Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Ann Neurol. 1998;44(3):410-3.
Montine, T. J., Markesbery, W. R., Morrow, J. D., & Roberts, L. J. (1998). Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. Annals of Neurology, 44(3), pp. 410-3.
Montine TJ, et al. Cerebrospinal Fluid F2-isoprostane Levels Are Increased in Alzheimer's Disease. Ann Neurol. 1998;44(3):410-3. PubMed PMID: 9749613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease. AU - Montine,T J, AU - Markesbery,W R, AU - Morrow,J D, AU - Roberts,L J,2nd PY - 1998/9/28/pubmed PY - 2001/3/28/medline PY - 1998/9/28/entrez SP - 410 EP - 3 JF - Annals of neurology JO - Ann. Neurol. VL - 44 IS - 3 N2 - Postmortem studies have associated Alzheimer's disease (AD) with regionally increased oxidative damage to brain. Lacking, however, is a specific marker of oxidative damage to brain that may be measured during life. We tested the hypothesis that cerebrospinal fluid (CSF) concentrations of F2-isoprostanes (F2-IsoPs), stable products of arachidonate peroxidation, are increased in CSF of AD patients. CSF from lateral ventricles (VF) was analyzed from 11 AD patients and 11 control subjects who participated in a rapid autopsy program. VF F2-IsoP concentrations were significantly elevated in AD patients compared with control subjects (72 +/- 7 vs 46 +/- 4 pg/ml) and were significantly linearly correlated with brain weight (-0.3 pg/ml/g, r2 = 0.32). These results suggest that quantification of CSF F2-IsoP concentrations may provide a useful biomarker of central nervous system oxidative damage in AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/9749613/Cerebrospinal_fluid_F2_isoprostane_levels_are_increased_in_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1998&volume=44&issue=3&spage=410 DB - PRIME DP - Unbound Medicine ER -