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Medications and cataract. The Blue Mountains Eye Study.
Ophthalmology. 1998 Sep; 105(9):1751-8.O

Abstract

PURPOSE

Corticosteroids are known to cause cataracts, but the effects of other medications on the lens are unclear. The aim of this study was to investigate the relationships between cataracts and a range of medications, including allopurinol, aspirin, chloroquine, diuretics, phenothiazines, and simvastatin.

DESIGN

Population-based cross-sectional study.

PARTICIPANTS

3654 individuals 49 to 97 years of age (response rate, 82%) from an urban community near Sydney, Australia, were included.

TESTING

Lens photography.

PRIMARY OUTCOME MEASURE

Lens photographs were graded for the presence and severity of cortical, nuclear, and posterior subcapsular cataract.

RESULTS

After adjusting for numerous potential confounders in ordinal regression models, use of phenothiazines was associated with nuclear cataract (adjusted odds ratio [OR], 2.18; 95% confidence interval [CI], 1.01-4.74); long-term aspirin users (> or = 10 years) had higher prevalence of posterior subcapsular cataract than did nonusers and short-term users (test for trend, P = 0.02); and the antimalarial drug mepacrine was associated with posterior subcapsular cataract (adjusted OR, 3.56; 95% CI, 1.56-8.13). There was a suggestion that use of chloroquine-like drugs for more than 1 year (test for trend, P = 0.12) might also be associated with posterior subcapsular cataract. Antihypertensive medications, cholesterol-lowering drugs, and allopurinol were not associated with any type of cataract. Potassium-sparing diuretics were the only diuretic to show any evidence of an association with cataract (test for trend for posterior subcapsular cataract, P = 0.14). Amiodarone was associated with cortical cataract (age- and gender-adjusted OR, 3.84; 95% CI, 1.01-14.81), but there were too few users to do analyses adjusted for multiple confounders.

CONCLUSIONS

Most drugs commonly used in the community do not appear to be associated with cataract. The findings of this study do not support the hypothesis that aspirin protects against cataract.

Authors+Show Affiliations

Department of Public Health and Community Medicine, University of Sydney, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9754187

Citation

Cumming, R G., and P Mitchell. "Medications and Cataract. the Blue Mountains Eye Study." Ophthalmology, vol. 105, no. 9, 1998, pp. 1751-8.
Cumming RG, Mitchell P. Medications and cataract. The Blue Mountains Eye Study. Ophthalmology. 1998;105(9):1751-8.
Cumming, R. G., & Mitchell, P. (1998). Medications and cataract. The Blue Mountains Eye Study. Ophthalmology, 105(9), 1751-8.
Cumming RG, Mitchell P. Medications and Cataract. the Blue Mountains Eye Study. Ophthalmology. 1998;105(9):1751-8. PubMed PMID: 9754187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medications and cataract. The Blue Mountains Eye Study. AU - Cumming,R G, AU - Mitchell,P, PY - 1998/10/1/pubmed PY - 2000/3/4/medline PY - 1998/10/1/entrez SP - 1751 EP - 8 JF - Ophthalmology JO - Ophthalmology VL - 105 IS - 9 N2 - PURPOSE: Corticosteroids are known to cause cataracts, but the effects of other medications on the lens are unclear. The aim of this study was to investigate the relationships between cataracts and a range of medications, including allopurinol, aspirin, chloroquine, diuretics, phenothiazines, and simvastatin. DESIGN: Population-based cross-sectional study. PARTICIPANTS: 3654 individuals 49 to 97 years of age (response rate, 82%) from an urban community near Sydney, Australia, were included. TESTING: Lens photography. PRIMARY OUTCOME MEASURE: Lens photographs were graded for the presence and severity of cortical, nuclear, and posterior subcapsular cataract. RESULTS: After adjusting for numerous potential confounders in ordinal regression models, use of phenothiazines was associated with nuclear cataract (adjusted odds ratio [OR], 2.18; 95% confidence interval [CI], 1.01-4.74); long-term aspirin users (> or = 10 years) had higher prevalence of posterior subcapsular cataract than did nonusers and short-term users (test for trend, P = 0.02); and the antimalarial drug mepacrine was associated with posterior subcapsular cataract (adjusted OR, 3.56; 95% CI, 1.56-8.13). There was a suggestion that use of chloroquine-like drugs for more than 1 year (test for trend, P = 0.12) might also be associated with posterior subcapsular cataract. Antihypertensive medications, cholesterol-lowering drugs, and allopurinol were not associated with any type of cataract. Potassium-sparing diuretics were the only diuretic to show any evidence of an association with cataract (test for trend for posterior subcapsular cataract, P = 0.14). Amiodarone was associated with cortical cataract (age- and gender-adjusted OR, 3.84; 95% CI, 1.01-14.81), but there were too few users to do analyses adjusted for multiple confounders. CONCLUSIONS: Most drugs commonly used in the community do not appear to be associated with cataract. The findings of this study do not support the hypothesis that aspirin protects against cataract. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/9754187/Medications_and_cataract__The_Blue_Mountains_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(98)99049-2 DB - PRIME DP - Unbound Medicine ER -