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Testing a genetic structure of blood-injury-injection fears.
Am J Med Genet. 1998 Sep 07; 81(5):377-84.AJ

Abstract

Multivariate genetic analyses were used to examine the genetic and environmental contributions to individual differences in fears of blood, injury, and injections in 659 twin pairs who completed questions concerning fear and fainting around blood, injury, and injections, and fainting in situations not involving blood, as well as the personality scales of Neuroticism, and Harm Avoidance. There was significant familial aggregation of blood fears but univariate analyses were unable to distinguish between additive genetic or shared environmental variables, or both, as the cause. The same was true of blood fainting. Non-blood-injury fainting was best explained by a model assuming shared and unique environmental variables. However, multivariate genetic analyses, which capitalise on extra information contained by all the covariance terms, indicated that the variance in blood-injury-injection fear was principally attributable to unique environmental events specific to this fear and additive genetic factors shared with fainting. The data are discussed in the context of models of blood-injury phobia that identify the need to consider separate etiological mechanisms for fear and fainting.

Authors+Show Affiliations

Page AC
Department of Psychology, University of Western Australia, Nedlands, Australia. andrew@psy.uwa.edu.au
Martin NG
No affiliation info available

MeSH

FemaleGenetic Predisposition to DiseaseGenome, HumanHumansMaleMultivariate AnalysisPhobic DisordersTwins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9754622

Citation

Page, A C., and N G. Martin. "Testing a Genetic Structure of Blood-injury-injection Fears." American Journal of Medical Genetics, vol. 81, no. 5, 1998, pp. 377-84.
Page AC, Martin NG. Testing a genetic structure of blood-injury-injection fears. Am J Med Genet. 1998;81(5):377-84.
Page, A. C., & Martin, N. G. (1998). Testing a genetic structure of blood-injury-injection fears. American Journal of Medical Genetics, 81(5), 377-84.
Page AC, Martin NG. Testing a Genetic Structure of Blood-injury-injection Fears. Am J Med Genet. 1998 Sep 7;81(5):377-84. PubMed PMID: 9754622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testing a genetic structure of blood-injury-injection fears. AU - Page,A C, AU - Martin,N G, PY - 1998/10/1/pubmed PY - 2000/6/20/medline PY - 1998/10/1/entrez SP - 377 EP - 84 JF - American journal of medical genetics JO - Am J Med Genet VL - 81 IS - 5 N2 - Multivariate genetic analyses were used to examine the genetic and environmental contributions to individual differences in fears of blood, injury, and injections in 659 twin pairs who completed questions concerning fear and fainting around blood, injury, and injections, and fainting in situations not involving blood, as well as the personality scales of Neuroticism, and Harm Avoidance. There was significant familial aggregation of blood fears but univariate analyses were unable to distinguish between additive genetic or shared environmental variables, or both, as the cause. The same was true of blood fainting. Non-blood-injury fainting was best explained by a model assuming shared and unique environmental variables. However, multivariate genetic analyses, which capitalise on extra information contained by all the covariance terms, indicated that the variance in blood-injury-injection fear was principally attributable to unique environmental events specific to this fear and additive genetic factors shared with fainting. The data are discussed in the context of models of blood-injury phobia that identify the need to consider separate etiological mechanisms for fear and fainting. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/9754622/Testing_a_genetic_structure_of_blood_injury_injection_fears_ DB - PRIME DP - Unbound Medicine ER -