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Timing of postprandial dyspeptic symptoms and transpyloric passage of gastric contents.
Scand J Gastroenterol. 1998 Aug; 33(8):822-7.SJ

Abstract

BACKGROUND

Patients with functional dyspepsia often experience early satiety and discomfort after a meal. The role of early gastric emptying in symptom generation is not known. Our aim was to relate timing of symptoms and early postprandial emptying in functional dyspepsia.

METHODS

Twelve patients with functional dyspepsia were investigated during 3 min of fasting, during 3 min of ingesting 500 ml of a meat soup, and during the first 10 min postprandially by means of duplex sonography.

RESULTS

Gastric emptying commenced on average 52 sec after the start of ingestion. Transpyloric movements of gastric contents unrelated to peristalsis (that is, alternating transpyloric emptying and reflux within a common chamber created by the terminal antrum, the pylorus, and the duodenal bulb) appeared before peristaltic-related emptying, which commenced after on average 116 sec. In all patients epigastric, meal-related discomfort was experienced after the commencement of transpyloric emptying, on average after 143 sec. A negative correlation was found between intensity of fullness and duration of presymptomatic transpyloric movements of gastric contents (that is, the duodenal 'tasting' period).

CONCLUSIONS

The early occurrence of meal-related symptoms suggests that gastric distension is the main factor in symptom generation. However, the onset of symptoms after the commencement of gastric emptying suggests that intestinal tasting receptors are involved in symptom generation. The inverse relationship between the duration of the tasting period and symptom intensity suggests that the time allowed for duodenal tasting might be too short in patients with FD.

Authors+Show Affiliations

Division of Gastroenterology, Medical Dept. A, Haukeland University Hospital, Bergen, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9754729

Citation

Hausken, T, et al. "Timing of Postprandial Dyspeptic Symptoms and Transpyloric Passage of Gastric Contents." Scandinavian Journal of Gastroenterology, vol. 33, no. 8, 1998, pp. 822-7.
Hausken T, Gilja OH, Undeland KA, et al. Timing of postprandial dyspeptic symptoms and transpyloric passage of gastric contents. Scand J Gastroenterol. 1998;33(8):822-7.
Hausken, T., Gilja, O. H., Undeland, K. A., & Berstad, A. (1998). Timing of postprandial dyspeptic symptoms and transpyloric passage of gastric contents. Scandinavian Journal of Gastroenterology, 33(8), 822-7.
Hausken T, et al. Timing of Postprandial Dyspeptic Symptoms and Transpyloric Passage of Gastric Contents. Scand J Gastroenterol. 1998;33(8):822-7. PubMed PMID: 9754729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Timing of postprandial dyspeptic symptoms and transpyloric passage of gastric contents. AU - Hausken,T, AU - Gilja,O H, AU - Undeland,K A, AU - Berstad,A, PY - 1998/10/1/pubmed PY - 1998/10/1/medline PY - 1998/10/1/entrez SP - 822 EP - 7 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 33 IS - 8 N2 - BACKGROUND: Patients with functional dyspepsia often experience early satiety and discomfort after a meal. The role of early gastric emptying in symptom generation is not known. Our aim was to relate timing of symptoms and early postprandial emptying in functional dyspepsia. METHODS: Twelve patients with functional dyspepsia were investigated during 3 min of fasting, during 3 min of ingesting 500 ml of a meat soup, and during the first 10 min postprandially by means of duplex sonography. RESULTS: Gastric emptying commenced on average 52 sec after the start of ingestion. Transpyloric movements of gastric contents unrelated to peristalsis (that is, alternating transpyloric emptying and reflux within a common chamber created by the terminal antrum, the pylorus, and the duodenal bulb) appeared before peristaltic-related emptying, which commenced after on average 116 sec. In all patients epigastric, meal-related discomfort was experienced after the commencement of transpyloric emptying, on average after 143 sec. A negative correlation was found between intensity of fullness and duration of presymptomatic transpyloric movements of gastric contents (that is, the duodenal 'tasting' period). CONCLUSIONS: The early occurrence of meal-related symptoms suggests that gastric distension is the main factor in symptom generation. However, the onset of symptoms after the commencement of gastric emptying suggests that intestinal tasting receptors are involved in symptom generation. The inverse relationship between the duration of the tasting period and symptom intensity suggests that the time allowed for duodenal tasting might be too short in patients with FD. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/9754729/Timing_of_postprandial_dyspeptic_symptoms_and_transpyloric_passage_of_gastric_contents_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365529850171477 DB - PRIME DP - Unbound Medicine ER -