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Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.
Eur J Pharmacol. 1998 Aug 14; 355(1):33-9.EJ

Abstract

A novel vasorelaxant peptide, adrenomedullin, its messenger ribonucleic acid (mRNA), and the mRNA for its receptor are highly expressed in the lung, suggesting that adrenomedullin may play a role in the regulation of the pulmonary circulation. We investigated whether the chronic infusion of rat adrenomedullin would affect pulmonary hypertension and right ventricular hypertrophy produced by the administration of monocrotaline. Four-week-old male Wistar rats received a single subcutaneous injection of 60 mg/kg monocrotaline and were then chronically and subcutaneously infused with rat adrenomedullin (PH + AM group, n = 8) or saline (PH group, n = 10) by an osmotic minipump for a period of 21 days. Plasma levels of adrenomedullin were significantly higher in the PH vs. the control group. The chronic infusion of adrenomedullin in rats with pulmonary hypertension increased the plasma levels of adrenomedullin to a value 94% greater than that of the control group and 55% greater than that of the untreated PH group. Chronic infusion of adrenomedullin significantly lessened the increase in right ventricular systolic pressure and the ratio of right ventricular weight to body weight seen after monocrotaline treatment. Histological examination revealed that adrenomedullin also attenuated the medial thickening of the pulmonary artery. These results suggest that chronic infusion of adrenomedullin attenuates the pulmonary hypertension and right ventricular hypertrophy seen in rats treated with monocrotaline.

Authors+Show Affiliations

Research Institute, National Cardiovascular Center, Suita, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9754936

Citation

Yoshihara, F, et al. "Chronic Infusion of Adrenomedullin Reduces Pulmonary Hypertension and Lessens Right Ventricular Hypertrophy in Rats Administered Monocrotaline." European Journal of Pharmacology, vol. 355, no. 1, 1998, pp. 33-9.
Yoshihara F, Nishikimi T, Horio T, et al. Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline. Eur J Pharmacol. 1998;355(1):33-9.
Yoshihara, F., Nishikimi, T., Horio, T., Yutani, C., Takishita, S., Matsuo, H., Ohe, T., & Kangawa, K. (1998). Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline. European Journal of Pharmacology, 355(1), 33-9.
Yoshihara F, et al. Chronic Infusion of Adrenomedullin Reduces Pulmonary Hypertension and Lessens Right Ventricular Hypertrophy in Rats Administered Monocrotaline. Eur J Pharmacol. 1998 Aug 14;355(1):33-9. PubMed PMID: 9754936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline. AU - Yoshihara,F, AU - Nishikimi,T, AU - Horio,T, AU - Yutani,C, AU - Takishita,S, AU - Matsuo,H, AU - Ohe,T, AU - Kangawa,K, PY - 1998/10/1/pubmed PY - 1998/10/1/medline PY - 1998/10/1/entrez SP - 33 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 355 IS - 1 N2 - A novel vasorelaxant peptide, adrenomedullin, its messenger ribonucleic acid (mRNA), and the mRNA for its receptor are highly expressed in the lung, suggesting that adrenomedullin may play a role in the regulation of the pulmonary circulation. We investigated whether the chronic infusion of rat adrenomedullin would affect pulmonary hypertension and right ventricular hypertrophy produced by the administration of monocrotaline. Four-week-old male Wistar rats received a single subcutaneous injection of 60 mg/kg monocrotaline and were then chronically and subcutaneously infused with rat adrenomedullin (PH + AM group, n = 8) or saline (PH group, n = 10) by an osmotic minipump for a period of 21 days. Plasma levels of adrenomedullin were significantly higher in the PH vs. the control group. The chronic infusion of adrenomedullin in rats with pulmonary hypertension increased the plasma levels of adrenomedullin to a value 94% greater than that of the control group and 55% greater than that of the untreated PH group. Chronic infusion of adrenomedullin significantly lessened the increase in right ventricular systolic pressure and the ratio of right ventricular weight to body weight seen after monocrotaline treatment. Histological examination revealed that adrenomedullin also attenuated the medial thickening of the pulmonary artery. These results suggest that chronic infusion of adrenomedullin attenuates the pulmonary hypertension and right ventricular hypertrophy seen in rats treated with monocrotaline. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/9754936/Chronic_infusion_of_adrenomedullin_reduces_pulmonary_hypertension_and_lessens_right_ventricular_hypertrophy_in_rats_administered_monocrotaline_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(98)00475-0 DB - PRIME DP - Unbound Medicine ER -