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Stability of cefazolin sodium eye drops.
J Clin Pharm Ther 1998; 23(1):41-7JC

Abstract

OBJECTIVE

Assessing the stability of cefazolin sodium in preservative-free and preservative-containing eye drops.

METHOD

Extemporaneous formulations of eye drops were prepared from a commercially-available parenteral product of cefazolin sodium: eye drops 'A' contained 50mg/ml of cefazolin sodium in 0.45% w/v sodium chloride solution, and eye drops 'B' contained 50 mg/ml, 0.005% w/v thiomersal and 1% w/v glycerol in water-for-injection. Cefazolin sodium concentrations in these eye drops were monitored by a stability-indicating HPLC assay method. Measurements of pH and osmolality, as well as tests for microbial contamination, were conducted.

RESULTS

The eye drops stored at 4 degrees C were stable for 42 days with minimal changes in pH and osmolality, but eye drops stored at room temperature were only stable for a few days with greater increments in pH and osmolality. None of the samples cultured had bacterial or fungal growth after 7 days of incubation.

CONCLUSION

Extemporaneously prepared formulations of cefazolin are unstable at room temperature and should be stored in a refrigerator.

Authors+Show Affiliations

National University Hospital, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9756111

Citation

How, T H., et al. "Stability of Cefazolin Sodium Eye Drops." Journal of Clinical Pharmacy and Therapeutics, vol. 23, no. 1, 1998, pp. 41-7.
How TH, Loo WY, Yow KL, et al. Stability of cefazolin sodium eye drops. J Clin Pharm Ther. 1998;23(1):41-7.
How, T. H., Loo, W. Y., Yow, K. L., Lim, L. Y., Chan, E. W., Ho, P. C., & Chan, S. Y. (1998). Stability of cefazolin sodium eye drops. Journal of Clinical Pharmacy and Therapeutics, 23(1), pp. 41-7.
How TH, et al. Stability of Cefazolin Sodium Eye Drops. J Clin Pharm Ther. 1998;23(1):41-7. PubMed PMID: 9756111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of cefazolin sodium eye drops. AU - How,T H, AU - Loo,W Y, AU - Yow,K L, AU - Lim,L Y, AU - Chan,E W, AU - Ho,P C, AU - Chan,S Y, PY - 1998/10/2/pubmed PY - 1998/10/2/medline PY - 1998/10/2/entrez SP - 41 EP - 7 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 23 IS - 1 N2 - OBJECTIVE: Assessing the stability of cefazolin sodium in preservative-free and preservative-containing eye drops. METHOD: Extemporaneous formulations of eye drops were prepared from a commercially-available parenteral product of cefazolin sodium: eye drops 'A' contained 50mg/ml of cefazolin sodium in 0.45% w/v sodium chloride solution, and eye drops 'B' contained 50 mg/ml, 0.005% w/v thiomersal and 1% w/v glycerol in water-for-injection. Cefazolin sodium concentrations in these eye drops were monitored by a stability-indicating HPLC assay method. Measurements of pH and osmolality, as well as tests for microbial contamination, were conducted. RESULTS: The eye drops stored at 4 degrees C were stable for 42 days with minimal changes in pH and osmolality, but eye drops stored at room temperature were only stable for a few days with greater increments in pH and osmolality. None of the samples cultured had bacterial or fungal growth after 7 days of incubation. CONCLUSION: Extemporaneously prepared formulations of cefazolin are unstable at room temperature and should be stored in a refrigerator. SN - 0269-4727 UR - https://www.unboundmedicine.com/medline/citation/9756111/Stability_of_cefazolin_sodium_eye_drops_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-4727&date=1998&volume=23&issue=1&spage=41 DB - PRIME DP - Unbound Medicine ER -