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Iron stores in man in relation to diet and iron requirements.
Eur J Clin Nutr. 1998 Sep; 52(9):623-31.EJ

Abstract

OBJECTIVE

To calculate iron stores in man and their rates of changes in relation to iron requirements and dietary iron intake and bioavailability.

METHOD

Newly established relationships between iron absorption from whole diets and serum ferritin (SF) and between SF and iron stores allow calculations of amounts of stored iron under different conditions (diets, losses) at stationary states when absorption equals losses. Rate of growth of stores can also be calculated. All calculations are based on observations and require no model assumptions.

RESULTS

Present calculations of iron stores agree with previously observed phlebotomy values. Differences in intake and bioavailability of dietary iron and in iron requirements had marked effects on amounts of stored iron. A wide range of diets was studied, from a hypothetical high-meat diet typical for early man to diets in developing countries. A new equation is given for the translation of SF into iron stores. Analyses of growth rate of stores under different conditions showed a fast growth from zero iron stores during the first year (reaching about 80% of final amounts) followed by a much slower rate for 2-3 y. A marked inertia was seen in rate of changes in iron stores that was more marked the closer stores were to their stationary states making it difficult to use SF to estimate short term changes in iron absorption in iron replete subjects.

CONCLUSIONS

Realistic Western-type diets with good bioavailability can cover iron requirements in most women and can restitute iron stores during lactation. The high prevalence of iron deficiency in menstruating Western women is thus mainly related to a further low bioavailability of iron in present diets. Present analyses also demonstrated an effective control of iron absorption preventing development of iron overload in otherwise healthy subjects even if the diet is fortified with iron and even if meat intake is high.

Authors+Show Affiliations

The Institute of Internal Medicine, Department of Clinical Nutrition, University of Göteborg, Annedalsklinikerna, Sahlgrenska University Hospital, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9756117

Citation

Hallberg, L, et al. "Iron Stores in Man in Relation to Diet and Iron Requirements." European Journal of Clinical Nutrition, vol. 52, no. 9, 1998, pp. 623-31.
Hallberg L, Hulthén L, Garby L. Iron stores in man in relation to diet and iron requirements. Eur J Clin Nutr. 1998;52(9):623-31.
Hallberg, L., Hulthén, L., & Garby, L. (1998). Iron stores in man in relation to diet and iron requirements. European Journal of Clinical Nutrition, 52(9), 623-31.
Hallberg L, Hulthén L, Garby L. Iron Stores in Man in Relation to Diet and Iron Requirements. Eur J Clin Nutr. 1998;52(9):623-31. PubMed PMID: 9756117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron stores in man in relation to diet and iron requirements. AU - Hallberg,L, AU - Hulthén,L, AU - Garby,L, PY - 1998/10/2/pubmed PY - 1998/10/2/medline PY - 1998/10/2/entrez SP - 623 EP - 31 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 52 IS - 9 N2 - OBJECTIVE: To calculate iron stores in man and their rates of changes in relation to iron requirements and dietary iron intake and bioavailability. METHOD: Newly established relationships between iron absorption from whole diets and serum ferritin (SF) and between SF and iron stores allow calculations of amounts of stored iron under different conditions (diets, losses) at stationary states when absorption equals losses. Rate of growth of stores can also be calculated. All calculations are based on observations and require no model assumptions. RESULTS: Present calculations of iron stores agree with previously observed phlebotomy values. Differences in intake and bioavailability of dietary iron and in iron requirements had marked effects on amounts of stored iron. A wide range of diets was studied, from a hypothetical high-meat diet typical for early man to diets in developing countries. A new equation is given for the translation of SF into iron stores. Analyses of growth rate of stores under different conditions showed a fast growth from zero iron stores during the first year (reaching about 80% of final amounts) followed by a much slower rate for 2-3 y. A marked inertia was seen in rate of changes in iron stores that was more marked the closer stores were to their stationary states making it difficult to use SF to estimate short term changes in iron absorption in iron replete subjects. CONCLUSIONS: Realistic Western-type diets with good bioavailability can cover iron requirements in most women and can restitute iron stores during lactation. The high prevalence of iron deficiency in menstruating Western women is thus mainly related to a further low bioavailability of iron in present diets. Present analyses also demonstrated an effective control of iron absorption preventing development of iron overload in otherwise healthy subjects even if the diet is fortified with iron and even if meat intake is high. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9756117/Iron_stores_in_man_in_relation_to_diet_and_iron_requirements_ L2 - https://doi.org/10.1038/sj.ejcn.1600623 DB - PRIME DP - Unbound Medicine ER -