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A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease.
Mov Disord. 1998 Sep; 13(5):782-7.MD

Abstract

Nine patients with advanced levodopa-responsive Parkinson's disease were enrolled in a double-blind, placebo-controlled crossover trial of intranasal apomorphine as rescue therapy for parkinsonian off-states. Patients were assigned in random order to each of four possible combinations of apomorphine, trimethobenzamide antiemetic, and their matched placebos and received detailed in-office motor scoring during each of the four study periods. Patients also completed diaries describing the effectiveness of the nasal spray for reversing off-states. A statistically significant reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score was seen following active apomorphine during in-office evaluation visits but not following placebo nasal spray. Patient diaries revealed that active apomorphine had a latency to onset of 11 minutes and a duration of 50 minutes. Significant nausea from apomorphine spray was seen in only one patient whereas nasal irritation was disabling in three and mild in two. We conclude that intranasal apomorphine is an effective rescue agent for parkinsonian off-states although nasal irritation is a limiting factor.

Authors+Show Affiliations

Department of Neurology, University of Texas Southwestern Medical School, Dallas 75235-8897, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9756146

Citation

Dewey, R B., et al. "A Double-blind, Placebo-controlled Study of Intranasal Apomorphine Spray as a Rescue Agent for Off-states in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 13, no. 5, 1998, pp. 782-7.
Dewey RB, Maraganore DM, Ahlskog JE, et al. A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease. Mov Disord. 1998;13(5):782-7.
Dewey, R. B., Maraganore, D. M., Ahlskog, J. E., & Matsumoto, J. Y. (1998). A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 13(5), 782-7.
Dewey RB, et al. A Double-blind, Placebo-controlled Study of Intranasal Apomorphine Spray as a Rescue Agent for Off-states in Parkinson's Disease. Mov Disord. 1998;13(5):782-7. PubMed PMID: 9756146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A double-blind, placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease. AU - Dewey,R B,Jr AU - Maraganore,D M, AU - Ahlskog,J E, AU - Matsumoto,J Y, PY - 1998/10/2/pubmed PY - 2001/3/28/medline PY - 1998/10/2/entrez SP - 782 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 13 IS - 5 N2 - Nine patients with advanced levodopa-responsive Parkinson's disease were enrolled in a double-blind, placebo-controlled crossover trial of intranasal apomorphine as rescue therapy for parkinsonian off-states. Patients were assigned in random order to each of four possible combinations of apomorphine, trimethobenzamide antiemetic, and their matched placebos and received detailed in-office motor scoring during each of the four study periods. Patients also completed diaries describing the effectiveness of the nasal spray for reversing off-states. A statistically significant reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score was seen following active apomorphine during in-office evaluation visits but not following placebo nasal spray. Patient diaries revealed that active apomorphine had a latency to onset of 11 minutes and a duration of 50 minutes. Significant nausea from apomorphine spray was seen in only one patient whereas nasal irritation was disabling in three and mild in two. We conclude that intranasal apomorphine is an effective rescue agent for parkinsonian off-states although nasal irritation is a limiting factor. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/9756146/A_double_blind_placebo_controlled_study_of_intranasal_apomorphine_spray_as_a_rescue_agent_for_off_states_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.870130505 DB - PRIME DP - Unbound Medicine ER -