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Basic therapies in cystic fibrosis. Does standard therapy work?

Abstract

Epidemiologic data demonstrate a dramatic improvement in survival for cystic fibrosis (CF) over the last few decades and projections suggest that trend will continue. Standard therapy works and should be aggressively applied to this patient population. Although the specific therapies have evolved over the years, the basic tenets of CF care remain unchanged and include antibiotics to control infection, airway clearance, and adequate nutrition. This article focuses on treatment of the pulmonary disease and includes a discussion of the following specific components of a standard therapeutic approach to CF: (1) antibiotics, (2) airway clearance and exercise, (3) mucolytics, (4) bronchodilators, (5) oxygen, (6) anti-inflammatory therapies, and (7) nutritional support. Judicious application of these therapies coupled with careful monitoring of pulmonary, nutritional, and metabolic parameters results in most CF patients surviving into adulthood with an acceptable quality of life.

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  • Authors+Show Affiliations

    ,

    Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Intermountain Cystic Fibrosis Center, University of Utah School of Medicine, Salt Lake City, USA.

    Source

    Clinics in chest medicine 19:3 1998 Sep pg 487-504, vi

    MeSH

    Anti-Bacterial Agents
    Bronchodilator Agents
    Cystic Fibrosis
    Expectorants
    Glucocorticoids
    Humans
    Nutritional Physiological Phenomena
    Respiratory Therapy

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    9759551

    Citation

    Marshall, B C., and W M. Samuelson. "Basic Therapies in Cystic Fibrosis. Does Standard Therapy Work?" Clinics in Chest Medicine, vol. 19, no. 3, 1998, pp. 487-504, vi.
    Marshall BC, Samuelson WM. Basic therapies in cystic fibrosis. Does standard therapy work? Clin Chest Med. 1998;19(3):487-504, vi.
    Marshall, B. C., & Samuelson, W. M. (1998). Basic therapies in cystic fibrosis. Does standard therapy work? Clinics in Chest Medicine, 19(3), pp. 487-504, vi.
    Marshall BC, Samuelson WM. Basic Therapies in Cystic Fibrosis. Does Standard Therapy Work. Clin Chest Med. 1998;19(3):487-504, vi. PubMed PMID: 9759551.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Basic therapies in cystic fibrosis. Does standard therapy work? AU - Marshall,B C, AU - Samuelson,W M, PY - 1998/10/6/pubmed PY - 1998/10/6/medline PY - 1998/10/6/entrez SP - 487-504, vi JF - Clinics in chest medicine JO - Clin. Chest Med. VL - 19 IS - 3 N2 - Epidemiologic data demonstrate a dramatic improvement in survival for cystic fibrosis (CF) over the last few decades and projections suggest that trend will continue. Standard therapy works and should be aggressively applied to this patient population. Although the specific therapies have evolved over the years, the basic tenets of CF care remain unchanged and include antibiotics to control infection, airway clearance, and adequate nutrition. This article focuses on treatment of the pulmonary disease and includes a discussion of the following specific components of a standard therapeutic approach to CF: (1) antibiotics, (2) airway clearance and exercise, (3) mucolytics, (4) bronchodilators, (5) oxygen, (6) anti-inflammatory therapies, and (7) nutritional support. Judicious application of these therapies coupled with careful monitoring of pulmonary, nutritional, and metabolic parameters results in most CF patients surviving into adulthood with an acceptable quality of life. SN - 0272-5231 UR - https://www.unboundmedicine.com/medline/citation/9759551/Basic_therapies_in_cystic_fibrosis__Does_standard_therapy_work L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-5231(05)70095-2 DB - PRIME DP - Unbound Medicine ER -