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Nonaqueous capillary electrophoresis--its applicability in the analysis of food, pharmaceuticals and biological fluids.
Electrophoresis. 1998 Sep; 19(12):2179-86.E

Abstract

The use of nonaqueous electrophoresis media for the application of capillary electrophoresis in the analysis of food, pharmaceuticals and biological fluids is reviewed. Some of the applications are discussed in detail and the benefits of using nonaqueous media in these cases are outlined. Three new applications within pharmaceutical analyses are presented. In these methods either a simple sample pretreatment by dilution with methanol (determination of chlorhexidine in a cream) or selective on-line capillary electrophoresis mass spectrometry (methods for identification of seizure drugs or opium alkaloids) are used. The choice of organic solvents and electrolytes for nonaqueous capillary electrophoresis are discussed. Furthermore, validation data obtained using capillary electrophoresis based on the nonaqueous principle are listed and discussed.

Authors+Show Affiliations

Bjørnsdottir I
Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Copenhagen.
Tjørnelund J
No affiliation info available
Hansen SH
No affiliation info available

MeSH

AnimalsBody FluidsChlorhexidineElectrolytesElectrophoresis, CapillaryFood AnalysisMass SpectrometryOpiumPharmaceutical PreparationsSolventsTechnology, Pharmaceutical

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9761201

Citation

Bjørnsdottir, I, et al. "Nonaqueous Capillary Electrophoresis--its Applicability in the Analysis of Food, Pharmaceuticals and Biological Fluids." Electrophoresis, vol. 19, no. 12, 1998, pp. 2179-86.
Bjørnsdottir I, Tjørnelund J, Hansen SH. Nonaqueous capillary electrophoresis--its applicability in the analysis of food, pharmaceuticals and biological fluids. Electrophoresis. 1998;19(12):2179-86.
Bjørnsdottir, I., Tjørnelund, J., & Hansen, S. H. (1998). Nonaqueous capillary electrophoresis--its applicability in the analysis of food, pharmaceuticals and biological fluids. Electrophoresis, 19(12), 2179-86.
Bjørnsdottir I, Tjørnelund J, Hansen SH. Nonaqueous Capillary Electrophoresis--its Applicability in the Analysis of Food, Pharmaceuticals and Biological Fluids. Electrophoresis. 1998;19(12):2179-86. PubMed PMID: 9761201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonaqueous capillary electrophoresis--its applicability in the analysis of food, pharmaceuticals and biological fluids. AU - Bjørnsdottir,I, AU - Tjørnelund,J, AU - Hansen,S H, PY - 1998/10/7/pubmed PY - 1998/10/7/medline PY - 1998/10/7/entrez SP - 2179 EP - 86 JF - Electrophoresis JO - Electrophoresis VL - 19 IS - 12 N2 - The use of nonaqueous electrophoresis media for the application of capillary electrophoresis in the analysis of food, pharmaceuticals and biological fluids is reviewed. Some of the applications are discussed in detail and the benefits of using nonaqueous media in these cases are outlined. Three new applications within pharmaceutical analyses are presented. In these methods either a simple sample pretreatment by dilution with methanol (determination of chlorhexidine in a cream) or selective on-line capillary electrophoresis mass spectrometry (methods for identification of seizure drugs or opium alkaloids) are used. The choice of organic solvents and electrolytes for nonaqueous capillary electrophoresis are discussed. Furthermore, validation data obtained using capillary electrophoresis based on the nonaqueous principle are listed and discussed. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/9761201/Nonaqueous_capillary_electrophoresis__its_applicability_in_the_analysis_of_food_pharmaceuticals_and_biological_fluids_ L2 - https://doi.org/10.1002/elps.1150191223 DB - PRIME DP - Unbound Medicine ER -