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Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma.
Pediatr Nephrol 1998; 12(7):572-5PN

Abstract

The acute renal effects of chemotherapy are known, but long-term nephrotoxicity has rarely been investigated. The aim of the present study was to assess long-term renal function in children and adolescents who received at-risk chemotherapy, including cisplatin, ifosfamide, and methotrexate, to treat an osteosarcoma. Renal function tests [creatinine clearance, microalbuminuria, and renal excretion of sodium, potassium, chloride, calcium, magnesium (Mg), phosphorus (P), and uric acid] were prospectively performed 5.4+/-2.2 (+/-SD) years after chemotherapy (total cumulative dose: methotrexate 41+/-31 g/m2, ifosfamide 39+/-14 g/m2, cisplatin 674+/-188 mg/m2) in 18 children and adolescents. The results were compared with 13 normal volunteers matched for age and sex. Creatinine clearance, which was greater than 80 ml/min per 1.73 m2 in all patients, correlated with the total dose of ifosfamide (r=0.55, P<0.05) and cisplatin (r=0.48, P<0.05). Microalbuminuria was noted in 4 patients. Hypomagnesemia was present in 4 and hypercalciuria in 3 patients; renal excretion of P, Mg, and uric acid was higher in patients than in controls. Glomerular function was not significantly altered and only mild tubular dysfunction was present. Since renal excretion of P and Mg were increased in patients compared with normal volunteers and hypercalciuria was occasionally seen, divalent ion disorders are the most-likely potential complications.

Authors+Show Affiliations

Unité de Néphrologie Pédiatrique, Hôpital Edouard Herriot and Université Claude Bernard, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9761357

Citation

Koch Nogueira, P C., et al. "Long-term Nephrotoxicity of Cisplatin, Ifosfamide, and Methotrexate in Osteosarcoma." Pediatric Nephrology (Berlin, Germany), vol. 12, no. 7, 1998, pp. 572-5.
Koch Nogueira PC, Hadj-Aïssa A, Schell M, et al. Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. Pediatr Nephrol. 1998;12(7):572-5.
Koch Nogueira, P. C., Hadj-Aïssa, A., Schell, M., Dubourg, L., Brunat-Mentigny, M., & Cochat, P. (1998). Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. Pediatric Nephrology (Berlin, Germany), 12(7), pp. 572-5.
Koch Nogueira PC, et al. Long-term Nephrotoxicity of Cisplatin, Ifosfamide, and Methotrexate in Osteosarcoma. Pediatr Nephrol. 1998;12(7):572-5. PubMed PMID: 9761357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. AU - Koch Nogueira,P C, AU - Hadj-Aïssa,A, AU - Schell,M, AU - Dubourg,L, AU - Brunat-Mentigny,M, AU - Cochat,P, PY - 1998/10/7/pubmed PY - 1998/10/7/medline PY - 1998/10/7/entrez SP - 572 EP - 5 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr. Nephrol. VL - 12 IS - 7 N2 - The acute renal effects of chemotherapy are known, but long-term nephrotoxicity has rarely been investigated. The aim of the present study was to assess long-term renal function in children and adolescents who received at-risk chemotherapy, including cisplatin, ifosfamide, and methotrexate, to treat an osteosarcoma. Renal function tests [creatinine clearance, microalbuminuria, and renal excretion of sodium, potassium, chloride, calcium, magnesium (Mg), phosphorus (P), and uric acid] were prospectively performed 5.4+/-2.2 (+/-SD) years after chemotherapy (total cumulative dose: methotrexate 41+/-31 g/m2, ifosfamide 39+/-14 g/m2, cisplatin 674+/-188 mg/m2) in 18 children and adolescents. The results were compared with 13 normal volunteers matched for age and sex. Creatinine clearance, which was greater than 80 ml/min per 1.73 m2 in all patients, correlated with the total dose of ifosfamide (r=0.55, P<0.05) and cisplatin (r=0.48, P<0.05). Microalbuminuria was noted in 4 patients. Hypomagnesemia was present in 4 and hypercalciuria in 3 patients; renal excretion of P, Mg, and uric acid was higher in patients than in controls. Glomerular function was not significantly altered and only mild tubular dysfunction was present. Since renal excretion of P and Mg were increased in patients compared with normal volunteers and hypercalciuria was occasionally seen, divalent ion disorders are the most-likely potential complications. SN - 0931-041X UR - https://www.unboundmedicine.com/medline/citation/9761357/Long_term_nephrotoxicity_of_cisplatin_ifosfamide_and_methotrexate_in_osteosarcoma_ L2 - https://dx.doi.org/10.1007/s004670050507 DB - PRIME DP - Unbound Medicine ER -