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Effects of a long-term inhalation of fragrances on the stress-induced immunosuppression in mice.
Neuroimmunomodulation. 1998 Nov-Dec; 5(6):318-22.N

Abstract

The aim of this study was to determine the effects of the long-term application of various fragrances on the suppression of immune response induced by high-pressure stress in mice. The immune response was analyzed based on plaque-forming cell (PFC) count, using mice sensitized with sheep red blood cells. The decreased PFC involving thymic involution induced by high-pressure stress in mice was restored by exposing the stressed mice to tuberose, lemon, oakmoss and labdanum for 24 h following exposure to stress. The decreased PFC and thymic involution from stress were restored by exposure to lemon and oakmoss, but not to tuberose and labdanum when the mice were exposed to those fragrances continuously for 3 weeks before the stress was given, followed by exposure to the same fragrances for 24 h after the stress. The decreased PFC and thymic involution from stress were restored by exposure to lemon and labdanum for 24 h after the stress, but not to tuberose over 3 weeks before the stress was given. These data suggest that the neuroimmunomodulatory effects of fragrances may be affected by tolerance depending on the kinds of fragrances in the case of a long-term application.

Authors+Show Affiliations

Department of Immunology, Kurume University School of Medicine, Kurume, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9762013

Citation

Fujiwara, R, et al. "Effects of a Long-term Inhalation of Fragrances On the Stress-induced Immunosuppression in Mice." Neuroimmunomodulation, vol. 5, no. 6, 1998, pp. 318-22.
Fujiwara R, Komori T, Noda Y, et al. Effects of a long-term inhalation of fragrances on the stress-induced immunosuppression in mice. Neuroimmunomodulation. 1998;5(6):318-22.
Fujiwara, R., Komori, T., Noda, Y., Kuraoka, T., Shibata, H., Shizuya, K., Miyahara, S., Ohmori, M., Nomura, J., & Yokoyama, M. M. (1998). Effects of a long-term inhalation of fragrances on the stress-induced immunosuppression in mice. Neuroimmunomodulation, 5(6), 318-22.
Fujiwara R, et al. Effects of a Long-term Inhalation of Fragrances On the Stress-induced Immunosuppression in Mice. Neuroimmunomodulation. 1998 Nov-Dec;5(6):318-22. PubMed PMID: 9762013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a long-term inhalation of fragrances on the stress-induced immunosuppression in mice. AU - Fujiwara,R, AU - Komori,T, AU - Noda,Y, AU - Kuraoka,T, AU - Shibata,H, AU - Shizuya,K, AU - Miyahara,S, AU - Ohmori,M, AU - Nomura,J, AU - Yokoyama,M M, PY - 1998/10/8/pubmed PY - 2000/8/16/medline PY - 1998/10/8/entrez SP - 318 EP - 22 JF - Neuroimmunomodulation JO - Neuroimmunomodulation VL - 5 IS - 6 N2 - The aim of this study was to determine the effects of the long-term application of various fragrances on the suppression of immune response induced by high-pressure stress in mice. The immune response was analyzed based on plaque-forming cell (PFC) count, using mice sensitized with sheep red blood cells. The decreased PFC involving thymic involution induced by high-pressure stress in mice was restored by exposing the stressed mice to tuberose, lemon, oakmoss and labdanum for 24 h following exposure to stress. The decreased PFC and thymic involution from stress were restored by exposure to lemon and oakmoss, but not to tuberose and labdanum when the mice were exposed to those fragrances continuously for 3 weeks before the stress was given, followed by exposure to the same fragrances for 24 h after the stress. The decreased PFC and thymic involution from stress were restored by exposure to lemon and labdanum for 24 h after the stress, but not to tuberose over 3 weeks before the stress was given. These data suggest that the neuroimmunomodulatory effects of fragrances may be affected by tolerance depending on the kinds of fragrances in the case of a long-term application. SN - 1021-7401 UR - https://www.unboundmedicine.com/medline/citation/9762013/Effects_of_a_long_term_inhalation_of_fragrances_on_the_stress_induced_immunosuppression_in_mice_ L2 - https://www.karger.com?DOI=10.1159/000026351 DB - PRIME DP - Unbound Medicine ER -