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Prolonged recovery in first-episode psychosis.
Br J Psychiatry Suppl. 1998; 172(33):107-16.BJ

Abstract

BACKGROUND

Early identification and specialised treatment of individuals with enduring positive symptoms may assist in alleviating symptoms and has the potential to change the course of illness.

METHOD

Prevalence and descriptive data on enduring positive symptoms in two first-episode samples are outlined. Attempts to incorporate the focus of early intervention for persisting psychosis into routine clinical care of individuals with first-episode psychosis are described.

RESULTS

Of the 227 individuals with first-episode psychosis who were assessed using the Brief Psychiatric Rating Scale at 3/6 months and 12 months following initial stabilisation (from a total sample of 347), 6.6% experienced enduring positive symptoms at all three time points. When the analysis was restricted to schizophrenia, schizophreniform and schizoaffective disorders (n = 158) the percentage increased to 8.9%. These patients had significantly longer mean duration of untreated psychosis prior to initiation of treatment and, at 12-month follow-up, significantly higher depression and poorer psychosocial functioning.

CONCLUSIONS

The association of untreated psychosis with treatment resistance supports the argument for early intervention as soon as possible following the onset of psychotic symptoms.

Authors+Show Affiliations

Centre for Young People's Mental Health, University of Melbourne, Parkville, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9764136

Citation

Edwards, J, et al. "Prolonged Recovery in First-episode Psychosis." The British Journal of Psychiatry. Supplement, vol. 172, no. 33, 1998, pp. 107-16.
Edwards J, Maude D, McGorry PD, et al. Prolonged recovery in first-episode psychosis. Br J Psychiatry Suppl. 1998;172(33):107-16.
Edwards, J., Maude, D., McGorry, P. D., Harrigan, S. M., & Cocks, J. T. (1998). Prolonged recovery in first-episode psychosis. The British Journal of Psychiatry. Supplement, 172(33), 107-16.
Edwards J, et al. Prolonged Recovery in First-episode Psychosis. Br J Psychiatry Suppl. 1998;172(33):107-16. PubMed PMID: 9764136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged recovery in first-episode psychosis. AU - Edwards,J, AU - Maude,D, AU - McGorry,P D, AU - Harrigan,S M, AU - Cocks,J T, PY - 1998/10/9/pubmed PY - 1998/10/9/medline PY - 1998/10/9/entrez SP - 107 EP - 16 JF - The British journal of psychiatry. Supplement JO - Br J Psychiatry Suppl VL - 172 IS - 33 N2 - BACKGROUND: Early identification and specialised treatment of individuals with enduring positive symptoms may assist in alleviating symptoms and has the potential to change the course of illness. METHOD: Prevalence and descriptive data on enduring positive symptoms in two first-episode samples are outlined. Attempts to incorporate the focus of early intervention for persisting psychosis into routine clinical care of individuals with first-episode psychosis are described. RESULTS: Of the 227 individuals with first-episode psychosis who were assessed using the Brief Psychiatric Rating Scale at 3/6 months and 12 months following initial stabilisation (from a total sample of 347), 6.6% experienced enduring positive symptoms at all three time points. When the analysis was restricted to schizophrenia, schizophreniform and schizoaffective disorders (n = 158) the percentage increased to 8.9%. These patients had significantly longer mean duration of untreated psychosis prior to initiation of treatment and, at 12-month follow-up, significantly higher depression and poorer psychosocial functioning. CONCLUSIONS: The association of untreated psychosis with treatment resistance supports the argument for early intervention as soon as possible following the onset of psychotic symptoms. SN - 0960-5371 UR - https://www.unboundmedicine.com/medline/citation/9764136/Prolonged_recovery_in_first_episode_psychosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9764136.ui DB - PRIME DP - Unbound Medicine ER -