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Phenotypic markers, sunlight-related factors and sunscreen use in patients with cutaneous melanoma: an Austrian case-control study.

Abstract

Sunscreens have been advocated to prevent burning in the hope that this will decrease the chance of developing melanoma. In a single-centre case-control study in Styria, Austria, we examined the risk of cutaneous malignant melanoma in relation to phenotypic markers, sunlight-related factors and sunscreen use. In total, 193 melanoma patients and 319 control subjects answered a comprehensive questionnaire regarding phenotypic markers, a variety of sunlight-related factors and sunscreen use. Risk factors for melanoma were examined through the use of unconditional logistic regression analysis, controlling for age and sex. Screening for confounding factors was done by forward and backward elimination of non-significant variables (P < 0.05). The resulting set of factors were investigated further for effect modification by introducing interactions into the model. The factor most significantly associated with increased melanoma risk was the use of sunscreens. Subjects who often used sunscreens had an increased odds ratio (OR) of 3.47 (95% confidence interval [CI]1.81-6.64) compared with subjects who never used sunscreens (P = 0.001), after adjustment for sex, age and other significant sunlight-related factors. Skin colour and higher numbers of sunbaths were significant protective factors. Subjects with medium skin colour had an adjusted OR of 0.63 (95% CI 0.41-0.99) compared with subjects with light skin colour (P = 0.0022). Subjects who took more than 30 sunbaths per year and subjects who took 20-30 sunbaths per year had, in the absence of sunburn(s), a decreased OR of 0.09 (95% CI 0.02-0.39) and 0.28 (95% CI 0.13-0.64), respectively, compared with subjects who took less than 20 sunbaths per year (P = 0.0002). However, sunbaths had no protective value when they were associated with sunburns. Although we cannot exclude the presence of an unknown confounding factor, our results suggest that the use of sunscreens does not help prevent melanoma.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Karl Franzens University, Graz, Austria. peter.wolf@kfunigraz.ac.at

    , , ,

    Source

    Melanoma research 8:4 1998 Aug pg 370-8

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Austria
    Case-Control Studies
    Drug Utilization
    Environmental Exposure
    Eye Color
    Female
    Genetic Markers
    Hair Color
    Heliotherapy
    Humans
    Leisure Activities
    Male
    Melanoma
    Melanosis
    Middle Aged
    Neoplasms, Radiation-Induced
    Odds Ratio
    Phenotype
    Risk Factors
    Skin Neoplasms
    Skin Pigmentation
    Sunburn
    Sunlight
    Sunscreening Agents
    Surveys and Questionnaires
    Treatment Failure

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    9764814

    Citation

    Wolf, P, et al. "Phenotypic Markers, Sunlight-related Factors and Sunscreen Use in Patients With Cutaneous Melanoma: an Austrian Case-control Study." Melanoma Research, vol. 8, no. 4, 1998, pp. 370-8.
    Wolf P, Quehenberger F, Müllegger R, et al. Phenotypic markers, sunlight-related factors and sunscreen use in patients with cutaneous melanoma: an Austrian case-control study. Melanoma Res. 1998;8(4):370-8.
    Wolf, P., Quehenberger, F., Müllegger, R., Stranz, B., & Kerl, H. (1998). Phenotypic markers, sunlight-related factors and sunscreen use in patients with cutaneous melanoma: an Austrian case-control study. Melanoma Research, 8(4), pp. 370-8.
    Wolf P, et al. Phenotypic Markers, Sunlight-related Factors and Sunscreen Use in Patients With Cutaneous Melanoma: an Austrian Case-control Study. Melanoma Res. 1998;8(4):370-8. PubMed PMID: 9764814.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Phenotypic markers, sunlight-related factors and sunscreen use in patients with cutaneous melanoma: an Austrian case-control study. AU - Wolf,P, AU - Quehenberger,F, AU - Müllegger,R, AU - Stranz,B, AU - Kerl,H, PY - 1998/10/9/pubmed PY - 1998/10/9/medline PY - 1998/10/9/entrez SP - 370 EP - 8 JF - Melanoma research JO - Melanoma Res. VL - 8 IS - 4 N2 - Sunscreens have been advocated to prevent burning in the hope that this will decrease the chance of developing melanoma. In a single-centre case-control study in Styria, Austria, we examined the risk of cutaneous malignant melanoma in relation to phenotypic markers, sunlight-related factors and sunscreen use. In total, 193 melanoma patients and 319 control subjects answered a comprehensive questionnaire regarding phenotypic markers, a variety of sunlight-related factors and sunscreen use. Risk factors for melanoma were examined through the use of unconditional logistic regression analysis, controlling for age and sex. Screening for confounding factors was done by forward and backward elimination of non-significant variables (P < 0.05). The resulting set of factors were investigated further for effect modification by introducing interactions into the model. The factor most significantly associated with increased melanoma risk was the use of sunscreens. Subjects who often used sunscreens had an increased odds ratio (OR) of 3.47 (95% confidence interval [CI]1.81-6.64) compared with subjects who never used sunscreens (P = 0.001), after adjustment for sex, age and other significant sunlight-related factors. Skin colour and higher numbers of sunbaths were significant protective factors. Subjects with medium skin colour had an adjusted OR of 0.63 (95% CI 0.41-0.99) compared with subjects with light skin colour (P = 0.0022). Subjects who took more than 30 sunbaths per year and subjects who took 20-30 sunbaths per year had, in the absence of sunburn(s), a decreased OR of 0.09 (95% CI 0.02-0.39) and 0.28 (95% CI 0.13-0.64), respectively, compared with subjects who took less than 20 sunbaths per year (P = 0.0002). However, sunbaths had no protective value when they were associated with sunburns. Although we cannot exclude the presence of an unknown confounding factor, our results suggest that the use of sunscreens does not help prevent melanoma. SN - 0960-8931 UR - https://www.unboundmedicine.com/medline/citation/9764814/Phenotypic_markers_sunlight_related_factors_and_sunscreen_use_in_patients_with_cutaneous_melanoma:_an_Austrian_case_control_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9764814.ui DB - PRIME DP - Unbound Medicine ER -