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Mutation of the MENIN gene in sporadic pancreatic endocrine tumors.
Cancer Res. 1998 Oct 01; 58(19):4417-20.CR

Abstract

Pancreatic endocrine tumors occur both sporadically and as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome. MEN1 is an autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. The MEN1 gene called MENIN maps to chromosome 11q13 and is thought to function as a tumor suppressor gene. We previously demonstrated loss of heterozygosity (LOH) at 11q13 in approximately 40% of sporadic pancreatic endocrine tumors and hypothesize that MENIN is involved in the development of these tumors. Thirty-one sporadic pancreatic endocrine tumors were analyzed for mutation of MENIN by nonradioactive single-stranded conformation polymorphism. Twelve mutations were detected in 31 sporadic pancreatic endocrine tumors (34%). Twelve of these 31 tumors previously demonstrated loss of heterozygosity at 11q13. Of the tumors with LOH, seven contained mutations of the MENIN gene (58%). The majority of the MENIN mutations occurred within exon 2. Two independent mutations in MENIN were detected in a gastrinoma that also revealed LOH, leading to the possibility of another tumor suppressor gene locus at 11q13. Mutations were present in both benign and malignant pancreatic endocrine tumors, suggesting that a MENIN gene mutation is a frequent and early event in the tumorigenesis. The high incidence of truncating mutations in tumors with LOH at 11q13 support the hypothesis that MENIN is a tumor suppressor gene.

Authors+Show Affiliations

Department of Surgery, West Los Angeles Veterans Affairs Medical Center and the UCLA School of Medicine, California 90073, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9766672

Citation

Wang, E H., et al. "Mutation of the MENIN Gene in Sporadic Pancreatic Endocrine Tumors." Cancer Research, vol. 58, no. 19, 1998, pp. 4417-20.
Wang EH, Ebrahimi SA, Wu AY, et al. Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Res. 1998;58(19):4417-20.
Wang, E. H., Ebrahimi, S. A., Wu, A. Y., Kashefi, C., Passaro, E., & Sawicki, M. P. (1998). Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Research, 58(19), 4417-20.
Wang EH, et al. Mutation of the MENIN Gene in Sporadic Pancreatic Endocrine Tumors. Cancer Res. 1998 Oct 1;58(19):4417-20. PubMed PMID: 9766672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. AU - Wang,E H, AU - Ebrahimi,S A, AU - Wu,A Y, AU - Kashefi,C, AU - Passaro,E,Jr AU - Sawicki,M P, PY - 1998/10/10/pubmed PY - 2001/3/28/medline PY - 1998/10/10/entrez SP - 4417 EP - 20 JF - Cancer research JO - Cancer Res. VL - 58 IS - 19 N2 - Pancreatic endocrine tumors occur both sporadically and as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome. MEN1 is an autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. The MEN1 gene called MENIN maps to chromosome 11q13 and is thought to function as a tumor suppressor gene. We previously demonstrated loss of heterozygosity (LOH) at 11q13 in approximately 40% of sporadic pancreatic endocrine tumors and hypothesize that MENIN is involved in the development of these tumors. Thirty-one sporadic pancreatic endocrine tumors were analyzed for mutation of MENIN by nonradioactive single-stranded conformation polymorphism. Twelve mutations were detected in 31 sporadic pancreatic endocrine tumors (34%). Twelve of these 31 tumors previously demonstrated loss of heterozygosity at 11q13. Of the tumors with LOH, seven contained mutations of the MENIN gene (58%). The majority of the MENIN mutations occurred within exon 2. Two independent mutations in MENIN were detected in a gastrinoma that also revealed LOH, leading to the possibility of another tumor suppressor gene locus at 11q13. Mutations were present in both benign and malignant pancreatic endocrine tumors, suggesting that a MENIN gene mutation is a frequent and early event in the tumorigenesis. The high incidence of truncating mutations in tumors with LOH at 11q13 support the hypothesis that MENIN is a tumor suppressor gene. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9766672/Mutation_of_the_MENIN_gene_in_sporadic_pancreatic_endocrine_tumors_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9766672 DB - PRIME DP - Unbound Medicine ER -