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Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects.
Am J Psychiatry 1998; 155(10):1384-91AJ

Abstract

OBJECTIVE

Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes of gray matter in the left posterior superior temporal gyrus and in medial temporal lobe structures. However, the specificity to schizophrenia and the roles of chronic morbidity and neuroleptic treatment in these abnormalities remain unclear.

METHOD

Magnetic resonance (1.5-T) scans were obtained from 33 patients with first-episode psychosis and 18 age-matched normal comparison subjects, all right-handed. Sixteen of the patients were diagnosed with affective disorder and 17 with schizophrenia.

RESULTS

Quantitative volumetric analysis showed that the patients with first-episode schizophrenia had significantly smaller gray matter volume in the left posterior superior temporal gyrus than did the patients with first-episode affective psychosis or the comparison subjects, with a significant left-less-than-right asymmetry. The schizophrenic patients also showed a smaller gray matter volume of the left posterior amygdala-hippocampal complex than the comparison subjects. Both the patients with schizophrenia and those with affective psychosis had significant left-less-than-right asymmetry of the posterior amygdala-hippocampal complex.

CONCLUSIONS

These findings suggest that temporal lobe abnormalities are present at the first hospitalization for schizophrenia and that low volume of the left posterior superior temporal gyrus gray matter is specific to schizophrenia compared with affective disorder.

Authors+Show Affiliations

Department of Psychiatry, Harvard Medical School, Brockton VA Medical Center, MA 02401, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9766770

Citation

Hirayasu, Y, et al. "Lower Left Temporal Lobe MRI Volumes in Patients With First-episode Schizophrenia Compared With Psychotic Patients With First-episode Affective Disorder and Normal Subjects." The American Journal of Psychiatry, vol. 155, no. 10, 1998, pp. 1384-91.
Hirayasu Y, Shenton ME, Salisbury DF, et al. Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry. 1998;155(10):1384-91.
Hirayasu, Y., Shenton, M. E., Salisbury, D. F., Dickey, C. C., Fischer, I. A., Mazzoni, P., ... McCarley, R. W. (1998). Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. The American Journal of Psychiatry, 155(10), pp. 1384-91.
Hirayasu Y, et al. Lower Left Temporal Lobe MRI Volumes in Patients With First-episode Schizophrenia Compared With Psychotic Patients With First-episode Affective Disorder and Normal Subjects. Am J Psychiatry. 1998;155(10):1384-91. PubMed PMID: 9766770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. AU - Hirayasu,Y, AU - Shenton,M E, AU - Salisbury,D F, AU - Dickey,C C, AU - Fischer,I A, AU - Mazzoni,P, AU - Kisler,T, AU - Arakaki,H, AU - Kwon,J S, AU - Anderson,J E, AU - Yurgelun-Todd,D, AU - Tohen,M, AU - McCarley,R W, PY - 1998/10/10/pubmed PY - 1998/10/10/medline PY - 1998/10/10/entrez SP - 1384 EP - 91 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 155 IS - 10 N2 - OBJECTIVE: Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes of gray matter in the left posterior superior temporal gyrus and in medial temporal lobe structures. However, the specificity to schizophrenia and the roles of chronic morbidity and neuroleptic treatment in these abnormalities remain unclear. METHOD: Magnetic resonance (1.5-T) scans were obtained from 33 patients with first-episode psychosis and 18 age-matched normal comparison subjects, all right-handed. Sixteen of the patients were diagnosed with affective disorder and 17 with schizophrenia. RESULTS: Quantitative volumetric analysis showed that the patients with first-episode schizophrenia had significantly smaller gray matter volume in the left posterior superior temporal gyrus than did the patients with first-episode affective psychosis or the comparison subjects, with a significant left-less-than-right asymmetry. The schizophrenic patients also showed a smaller gray matter volume of the left posterior amygdala-hippocampal complex than the comparison subjects. Both the patients with schizophrenia and those with affective psychosis had significant left-less-than-right asymmetry of the posterior amygdala-hippocampal complex. CONCLUSIONS: These findings suggest that temporal lobe abnormalities are present at the first hospitalization for schizophrenia and that low volume of the left posterior superior temporal gyrus gray matter is specific to schizophrenia compared with affective disorder. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/9766770/Lower_left_temporal_lobe_MRI_volumes_in_patients_with_first_episode_schizophrenia_compared_with_psychotic_patients_with_first_episode_affective_disorder_and_normal_subjects_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.155.10.1384?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -