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Resting energy expenditure and body composition in children with HIV infection.

Abstract

The purpose of this study was to determine whether alterations in body composition, resting energy expenditure (REE), and dietary energy intake are associated with growth retardation in HIV-positive children. Body composition (deuterium oxide dilution, skinfold measurements), REE (indirect calorimetry), and energy intake (24-hour weighed food intake) were evaluated in three groups: HIV-positive with growth retardation (HIV+Gr), HIV-positive with normal growth (HIV+); and HIV-uninfected with normal growth (HIV-). Children were between 2 and 11 years of age, afebrile, and free from acute infection. Forty-two children (13 HIV+Gr, 19 HIV+, 10 HIV-) were studied. Lean body mass was significantly reduced in HIV+Gr compared with HIV- (p < .05), and fat mass was significantly reduced in HIV+Gr and HIV+ compared with HIV- (p < .05). The percentages of lean and fat mass were not significantly different between groups, suggesting that differences in lean and fat mass were proportional to differences in body size. Consistent with reduced lean body mass, mean REE was significantly lower in HIV+Gr compared with HIV- (p < .05). Differences in mean REE/kg of body weight or lean body mass between groups were not statistically significant. A significant negative correlation was found between REE (kcal/kg/day) and weight-for-age (p = .04), and a trend with height-for-age Z-score (p = .07). Mean energy intake was not significantly different between groups. This study suggests that lean and fat mass are proportionately reduced in HIV-positive children with growth retardation. Further studies are necessary to delineate the relationship between energy balance and growth in children with HIV infection.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics and Center for Human Nutrition, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

    , , ,

    Source

    MeSH

    Adipose Tissue
    Anthropometry
    Anti-HIV Agents
    Arm
    Body Composition
    Body Water
    Child
    Child Development
    Child, Preschool
    Didanosine
    Energy Intake
    Energy Metabolism
    Female
    Growth Disorders
    HIV Infections
    Humans
    Male
    Muscle Development
    Muscle, Skeletal
    Skinfold Thickness
    Zidovudine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9768624

    Citation

    Henderson, R A., et al. "Resting Energy Expenditure and Body Composition in Children With HIV Infection." Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association, vol. 19, no. 2, 1998, pp. 150-7.
    Henderson RA, Talusan K, Hutton N, et al. Resting energy expenditure and body composition in children with HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19(2):150-7.
    Henderson, R. A., Talusan, K., Hutton, N., Yolken, R. H., & Caballero, B. (1998). Resting energy expenditure and body composition in children with HIV infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association, 19(2), pp. 150-7.
    Henderson RA, et al. Resting Energy Expenditure and Body Composition in Children With HIV Infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):150-7. PubMed PMID: 9768624.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Resting energy expenditure and body composition in children with HIV infection. AU - Henderson,R A, AU - Talusan,K, AU - Hutton,N, AU - Yolken,R H, AU - Caballero,B, PY - 1998/10/13/pubmed PY - 1998/10/13/medline PY - 1998/10/13/entrez SP - 150 EP - 7 JF - Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association JO - J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. VL - 19 IS - 2 N2 - The purpose of this study was to determine whether alterations in body composition, resting energy expenditure (REE), and dietary energy intake are associated with growth retardation in HIV-positive children. Body composition (deuterium oxide dilution, skinfold measurements), REE (indirect calorimetry), and energy intake (24-hour weighed food intake) were evaluated in three groups: HIV-positive with growth retardation (HIV+Gr), HIV-positive with normal growth (HIV+); and HIV-uninfected with normal growth (HIV-). Children were between 2 and 11 years of age, afebrile, and free from acute infection. Forty-two children (13 HIV+Gr, 19 HIV+, 10 HIV-) were studied. Lean body mass was significantly reduced in HIV+Gr compared with HIV- (p < .05), and fat mass was significantly reduced in HIV+Gr and HIV+ compared with HIV- (p < .05). The percentages of lean and fat mass were not significantly different between groups, suggesting that differences in lean and fat mass were proportional to differences in body size. Consistent with reduced lean body mass, mean REE was significantly lower in HIV+Gr compared with HIV- (p < .05). Differences in mean REE/kg of body weight or lean body mass between groups were not statistically significant. A significant negative correlation was found between REE (kcal/kg/day) and weight-for-age (p = .04), and a trend with height-for-age Z-score (p = .07). Mean energy intake was not significantly different between groups. This study suggests that lean and fat mass are proportionately reduced in HIV-positive children with growth retardation. Further studies are necessary to delineate the relationship between energy balance and growth in children with HIV infection. SN - 1077-9450 UR - https://www.unboundmedicine.com/medline/citation/9768624/Resting_energy_expenditure_and_body_composition_in_children_with_HIV_infection_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9768624.ui DB - PRIME DP - Unbound Medicine ER -