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Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease.
Circulation. 1998 Oct 13; 98(15):1487-94.Circ

Abstract

BACKGROUND

The association between oxidative modifications of LDL and coronary artery disease (CAD) is suspected but not established. Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stable CAD was investigated.

METHODS AND RESULTS

The study population contained 63 patients with acute coronary syndromes (45 with acute myocardial infarction and 18 with unstable angina pectoris), 35 nontransplanted patients with angiographically confirmed stable angina, 28 heart transplant patients with posttransplant CAD, 79 heart transplant patients without CAD, and 65 control subjects. After correction for age, sex, and LDL and HDL cholesterol, plasma levels of oxidized LDL and MDA-modified LDL were significantly higher in patients with CAD than in individuals without CAD (r2=0.57 and r2=0.26, respectively; both P=0.0001). Plasma levels of MDA-modified LDL were significantly higher in patients with acute coronary syndromes than in individuals with stable CAD (r2=0.65; P=0.0001) and were associated with increased levels of troponin I and C-reactive protein (r2=0.39 and r2=0.34, respectively; both P=0.0001). Plasma levels of oxidized LDL were not associated with increased levels of troponin I and C-reactive protein (r2=0.089 and r2=0.063, respectively).

CONCLUSIONS

Elevated plasma levels of oxidized LDL are associated with CAD. Elevated plasma levels of MDA-modified LDL suggest plaque instability and may be useful for the identification of patients with acute coronary syndromes.

Authors+Show Affiliations

Center for Molecular and Vascular Biology, University of Leuven, Belgium paul.holvoet@med.kuleuven.ag.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9769301

Citation

Holvoet, P, et al. "Oxidized LDL and Malondialdehyde-modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery Disease." Circulation, vol. 98, no. 15, 1998, pp. 1487-94.
Holvoet P, Vanhaecke J, Janssens S, et al. Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation. 1998;98(15):1487-94.
Holvoet, P., Vanhaecke, J., Janssens, S., Van de Werf, F., & Collen, D. (1998). Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation, 98(15), 1487-94.
Holvoet P, et al. Oxidized LDL and Malondialdehyde-modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery Disease. Circulation. 1998 Oct 13;98(15):1487-94. PubMed PMID: 9769301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. AU - Holvoet,P, AU - Vanhaecke,J, AU - Janssens,S, AU - Van de Werf,F, AU - Collen,D, PY - 1998/10/14/pubmed PY - 1998/10/14/medline PY - 1998/10/14/entrez SP - 1487 EP - 94 JF - Circulation JO - Circulation VL - 98 IS - 15 N2 - BACKGROUND: The association between oxidative modifications of LDL and coronary artery disease (CAD) is suspected but not established. Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stable CAD was investigated. METHODS AND RESULTS: The study population contained 63 patients with acute coronary syndromes (45 with acute myocardial infarction and 18 with unstable angina pectoris), 35 nontransplanted patients with angiographically confirmed stable angina, 28 heart transplant patients with posttransplant CAD, 79 heart transplant patients without CAD, and 65 control subjects. After correction for age, sex, and LDL and HDL cholesterol, plasma levels of oxidized LDL and MDA-modified LDL were significantly higher in patients with CAD than in individuals without CAD (r2=0.57 and r2=0.26, respectively; both P=0.0001). Plasma levels of MDA-modified LDL were significantly higher in patients with acute coronary syndromes than in individuals with stable CAD (r2=0.65; P=0.0001) and were associated with increased levels of troponin I and C-reactive protein (r2=0.39 and r2=0.34, respectively; both P=0.0001). Plasma levels of oxidized LDL were not associated with increased levels of troponin I and C-reactive protein (r2=0.089 and r2=0.063, respectively). CONCLUSIONS: Elevated plasma levels of oxidized LDL are associated with CAD. Elevated plasma levels of MDA-modified LDL suggest plaque instability and may be useful for the identification of patients with acute coronary syndromes. SN - 0009-7322 UR - https://www.unboundmedicine.com/medline/citation/9769301/Oxidized_LDL_and_malondialdehyde_modified_LDL_in_patients_with_acute_coronary_syndromes_and_stable_coronary_artery_disease_ L2 - https://www.ahajournals.org/doi/10.1161/01.cir.98.15.1487?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -