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[The role of hyper-homocysteinemia in the etiology of some vascular diseases].
Orv Hetil 1998; 139(37):2191-6OH

Abstract

About 5% of population have a highly, while other 15% a moderately elevated plasma homocysteine level. Hyperhomocysteinemia may be responsible about 10-20% of coronary artery, 40% of cerebrovascular and 60% of peripheral vascular diseases. There in an inverse relationship between folate, cobalamin and pyridoxine intake or blood level and plasma homocysteine level. In addition, the intake of these three B vitamins can reduce high plasma homocysteine level. Folate-folic acid seems to be the most important in homocysteine reduction due to the compensation of thermolabile methylenetetrahydrofolate reductase insufficiency, however, a milder impact of cobalamin any pyridoxine (mainly following a methionine load test) is also proved. There are possibilities to reduce risk associated with elevated homocysteine: e. g. dietary supplementation or food fortification. In Hungary bread enriched by folic acid, cobalamin and pyriodixine might reduce rate of vascular diseases due to hyperhomocysteinemia.

Authors+Show Affiliations

Nemzeti Egészségvédelmi Intézet, Budapest.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

hun

PubMed ID

9769688

Citation

Czeizel, E, and L Matos. "[The Role of Hyper-homocysteinemia in the Etiology of some Vascular Diseases]." Orvosi Hetilap, vol. 139, no. 37, 1998, pp. 2191-6.
Czeizel E, Matos L. [The role of hyper-homocysteinemia in the etiology of some vascular diseases]. Orv Hetil. 1998;139(37):2191-6.
Czeizel, E., & Matos, L. (1998). [The role of hyper-homocysteinemia in the etiology of some vascular diseases]. Orvosi Hetilap, 139(37), pp. 2191-6.
Czeizel E, Matos L. [The Role of Hyper-homocysteinemia in the Etiology of some Vascular Diseases]. Orv Hetil. 1998 Sep 13;139(37):2191-6. PubMed PMID: 9769688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of hyper-homocysteinemia in the etiology of some vascular diseases]. AU - Czeizel,E, AU - Matos,L, PY - 1998/10/14/pubmed PY - 1998/10/14/medline PY - 1998/10/14/entrez SP - 2191 EP - 6 JF - Orvosi hetilap JO - Orv Hetil VL - 139 IS - 37 N2 - About 5% of population have a highly, while other 15% a moderately elevated plasma homocysteine level. Hyperhomocysteinemia may be responsible about 10-20% of coronary artery, 40% of cerebrovascular and 60% of peripheral vascular diseases. There in an inverse relationship between folate, cobalamin and pyridoxine intake or blood level and plasma homocysteine level. In addition, the intake of these three B vitamins can reduce high plasma homocysteine level. Folate-folic acid seems to be the most important in homocysteine reduction due to the compensation of thermolabile methylenetetrahydrofolate reductase insufficiency, however, a milder impact of cobalamin any pyridoxine (mainly following a methionine load test) is also proved. There are possibilities to reduce risk associated with elevated homocysteine: e. g. dietary supplementation or food fortification. In Hungary bread enriched by folic acid, cobalamin and pyriodixine might reduce rate of vascular diseases due to hyperhomocysteinemia. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/9769688/[The_role_of_hyper_homocysteinemia_in_the_etiology_of_some_vascular_diseases]_ L2 - http://www.diseaseinfosearch.org/result/3460 DB - PRIME DP - Unbound Medicine ER -