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Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension.
Am J Gastroenterol. 1998 Oct; 93(10):1823-8.AJ

Abstract

OBJECTIVE

Transient lower esophageal sphincter relaxations (TLESRs) are the main mechanism underlying gastroesophageal reflux. In the present study we evaluated the effect of loxiglumide, a specific cholecystokininA (CCKA)-receptor antagonist, on the occurrence of TLESRs evoked by gastric distension.

METHODS

Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide (10 mg/kg/h) in a randomized double-blind order. Gastric distension was induced by inflation of 400 ml of air.

RESULTS

Basal lower esophageal pressure (LESP) and swallow-induced relaxation were not affected by loxiglumide. Loxiglumide significantly reduced the number of TLESRs, from 11.5 (5.8-18.3) to 6.0 (3.3-14.3) during the total recording period of 1 h, and from 5.5 (4.25-7.5) to 2.0 (0.5-6.8) during the first 15 min. The number of common cavities was significantly decreased by loxiglumide, from 8.0 (4.0-20.0) to 5.0 (2.0-7.8). TLESRs represented the main mechanism (60% during placebo, 74% during loxiglumide) underlying common cavities, followed by swallow-induced relaxation.

CONCLUSIONS

Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter, suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9772038

Citation

Boeckxstaens, G E., et al. "Involvement of cholecystokininA Receptors in Transient Lower Esophageal Sphincter Relaxations Triggered By Gastric Distension." The American Journal of Gastroenterology, vol. 93, no. 10, 1998, pp. 1823-8.
Boeckxstaens GE, Hirsch DP, Fakhry N, et al. Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension. Am J Gastroenterol. 1998;93(10):1823-8.
Boeckxstaens, G. E., Hirsch, D. P., Fakhry, N., Holloway, R. H., D'Amato, M., & Tytgat, G. N. (1998). Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension. The American Journal of Gastroenterology, 93(10), 1823-8.
Boeckxstaens GE, et al. Involvement of cholecystokininA Receptors in Transient Lower Esophageal Sphincter Relaxations Triggered By Gastric Distension. Am J Gastroenterol. 1998;93(10):1823-8. PubMed PMID: 9772038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension. AU - Boeckxstaens,G E, AU - Hirsch,D P, AU - Fakhry,N, AU - Holloway,R H, AU - D'Amato,M, AU - Tytgat,G N, PY - 1998/10/15/pubmed PY - 1998/10/15/medline PY - 1998/10/15/entrez SP - 1823 EP - 8 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 93 IS - 10 N2 - OBJECTIVE: Transient lower esophageal sphincter relaxations (TLESRs) are the main mechanism underlying gastroesophageal reflux. In the present study we evaluated the effect of loxiglumide, a specific cholecystokininA (CCKA)-receptor antagonist, on the occurrence of TLESRs evoked by gastric distension. METHODS: Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide (10 mg/kg/h) in a randomized double-blind order. Gastric distension was induced by inflation of 400 ml of air. RESULTS: Basal lower esophageal pressure (LESP) and swallow-induced relaxation were not affected by loxiglumide. Loxiglumide significantly reduced the number of TLESRs, from 11.5 (5.8-18.3) to 6.0 (3.3-14.3) during the total recording period of 1 h, and from 5.5 (4.25-7.5) to 2.0 (0.5-6.8) during the first 15 min. The number of common cavities was significantly decreased by loxiglumide, from 8.0 (4.0-20.0) to 5.0 (2.0-7.8). TLESRs represented the main mechanism (60% during placebo, 74% during loxiglumide) underlying common cavities, followed by swallow-induced relaxation. CONCLUSIONS: Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter, suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9772038/Involvement_of_cholecystokininA_receptors_in_transient_lower_esophageal_sphincter_relaxations_triggered_by_gastric_distension_ L2 - https://Insights.ovid.com/pubmed?pmid=9772038 DB - PRIME DP - Unbound Medicine ER -