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Variations in dietary fat and cholesterol intakes modify antioxidant status of SHR and WKY rats.
J Nutr. 1998 Oct; 128(10):1620-30.JN

Abstract

The effects of varying dietary fat saturation [butter (B), beef tallow (BT)] or polyunsaturation [(n-6) soybean oil (SBO), (n-3) menhaden oil (MO)] and cholesterol content (0.05 and 0.5 g/100 g) on systolic blood pressure (SBP), plasma lipids and tissue antioxidant status were investigated in 14-wk-old spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats. Varying dietary fat composition for 9 wk had no influence on SBP in either SHR or WKY rats. Rats fed MO diets exhibited smaller (P < 0.05) body weight gains, lower (P < 0.05) feed efficiency ratios and lower (P < 0.05) plasma cholesterol concentrations than those fed the B, BT and SBO diets. Significant (P < 0.05) interactions for animal strain x cholesterol intake and animal strain x fat source were noted for serum cholesterol concentrations. SHR exhibited higher (P < 0.05) RBC and liver catalase (CAT), and heart and liver superoxide dismutase (SOD) activities similar to those of WKY rats. The lower (P <0.01) RBC, heart and liver glutathione peroxidase (GSH-Px) activities observed in SHR coincided with higher (P <0.01) glutathione reductase (GSSG-Red), compared with WKY rats. Dietary cholesterol intake had no effect on RBC, heart and liver total sulfhydryl concentration or GSH-Px activities, but increased (P <0. 001) liver GSSG-Red. Feeding MO resulted in lower (P <0.001) RBC and heart GSH-Px activities. In contrast, feeding B and BT resulted in lower GSH-Px in liver. The significant (P < 0.01) animal strain x fat source interaction obtained for liver GSH-Px activity indicated that SHR responded differently to polyunsaturated fatty acid feeding than their WKY counterparts. Diet-induced changes in tissue antioxidant status were tissue specific and did not affect the development of hypertension in SHR.

Authors+Show Affiliations

Department of Food Science, Faculty of Agriculture, University of British Columbia, Vancouver, BC, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9772127

Citation

Yuan, Y V., et al. "Variations in Dietary Fat and Cholesterol Intakes Modify Antioxidant Status of SHR and WKY Rats." The Journal of Nutrition, vol. 128, no. 10, 1998, pp. 1620-30.
Yuan YV, Kitts DD, Godin DV. Variations in dietary fat and cholesterol intakes modify antioxidant status of SHR and WKY rats. J Nutr. 1998;128(10):1620-30.
Yuan, Y. V., Kitts, D. D., & Godin, D. V. (1998). Variations in dietary fat and cholesterol intakes modify antioxidant status of SHR and WKY rats. The Journal of Nutrition, 128(10), 1620-30.
Yuan YV, Kitts DD, Godin DV. Variations in Dietary Fat and Cholesterol Intakes Modify Antioxidant Status of SHR and WKY Rats. J Nutr. 1998;128(10):1620-30. PubMed PMID: 9772127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in dietary fat and cholesterol intakes modify antioxidant status of SHR and WKY rats. AU - Yuan,Y V, AU - Kitts,D D, AU - Godin,D V, PY - 1998/10/15/pubmed PY - 1998/10/15/medline PY - 1998/10/15/entrez SP - 1620 EP - 30 JF - The Journal of nutrition JO - J Nutr VL - 128 IS - 10 N2 - The effects of varying dietary fat saturation [butter (B), beef tallow (BT)] or polyunsaturation [(n-6) soybean oil (SBO), (n-3) menhaden oil (MO)] and cholesterol content (0.05 and 0.5 g/100 g) on systolic blood pressure (SBP), plasma lipids and tissue antioxidant status were investigated in 14-wk-old spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats. Varying dietary fat composition for 9 wk had no influence on SBP in either SHR or WKY rats. Rats fed MO diets exhibited smaller (P < 0.05) body weight gains, lower (P < 0.05) feed efficiency ratios and lower (P < 0.05) plasma cholesterol concentrations than those fed the B, BT and SBO diets. Significant (P < 0.05) interactions for animal strain x cholesterol intake and animal strain x fat source were noted for serum cholesterol concentrations. SHR exhibited higher (P < 0.05) RBC and liver catalase (CAT), and heart and liver superoxide dismutase (SOD) activities similar to those of WKY rats. The lower (P <0.01) RBC, heart and liver glutathione peroxidase (GSH-Px) activities observed in SHR coincided with higher (P <0.01) glutathione reductase (GSSG-Red), compared with WKY rats. Dietary cholesterol intake had no effect on RBC, heart and liver total sulfhydryl concentration or GSH-Px activities, but increased (P <0. 001) liver GSSG-Red. Feeding MO resulted in lower (P <0.001) RBC and heart GSH-Px activities. In contrast, feeding B and BT resulted in lower GSH-Px in liver. The significant (P < 0.01) animal strain x fat source interaction obtained for liver GSH-Px activity indicated that SHR responded differently to polyunsaturated fatty acid feeding than their WKY counterparts. Diet-induced changes in tissue antioxidant status were tissue specific and did not affect the development of hypertension in SHR. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/9772127/Variations_in_dietary_fat_and_cholesterol_intakes_modify_antioxidant_status_of_SHR_and_WKY_rats_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/128.10.1620 DB - PRIME DP - Unbound Medicine ER -