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[Effect of (+/-)12-chloroscoulerine on brain dopamine receptors].
Zhongguo Yao Li Xue Bao. 1996 Mar; 17(2):185-9.ZY

Abstract

AIM

To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors.

METHODS

The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used.

RESULTS

(+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors.

CONCLUSION

CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine.

Authors+Show Affiliations

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

9772676

Citation

Chen, L J., et al. "[Effect of (+/-)12-chloroscoulerine On Brain Dopamine Receptors]." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 17, no. 2, 1996, pp. 185-9.
Chen LJ, Xi Y, Pang DW, et al. [Effect of (+/-)12-chloroscoulerine on brain dopamine receptors]. Zhongguo Yao Li Xue Bao. 1996;17(2):185-9.
Chen, L. J., Xi, Y., Pang, D. W., Zhou, Q. T., & Jin, G. Z. (1996). [Effect of (+/-)12-chloroscoulerine on brain dopamine receptors]. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 17(2), 185-9.
Chen LJ, et al. [Effect of (+/-)12-chloroscoulerine On Brain Dopamine Receptors]. Zhongguo Yao Li Xue Bao. 1996;17(2):185-9. PubMed PMID: 9772676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of (+/-)12-chloroscoulerine on brain dopamine receptors]. AU - Chen,L J, AU - Xi,Y, AU - Pang,D W, AU - Zhou,Q T, AU - Jin,G Z, PY - 1996/3/1/pubmed PY - 1998/10/17/medline PY - 1996/3/1/entrez SP - 185 EP - 9 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 17 IS - 2 N2 - AIM: To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors. METHODS: The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used. RESULTS: (+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors. CONCLUSION: CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/9772676/[Effect_of__+/__12_chloroscoulerine_on_brain_dopamine_receptors]_ L2 - http://www.chinaphar.com/1671-4083/17/185.pdf DB - PRIME DP - Unbound Medicine ER -