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RETRACTED ARTICLE

Prevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: a randomized, double-blind, placebo-controlled trial.
Acta Anaesthesiol Scand. 1998 Sep; 42(8):921-5.AA

Abstract

BACKGROUND

Nausea and vomiting during and after spinal anaesthesia for caesarean section are distressing to the patient. This study was undertaken to evaluate the efficacy and safety of granisetron, droperidol and metoclopramide for the prevention of nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia.

METHODS

In a randomized, double-blind, placebo-controlled trial, 120 patients received granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg or placebo (saline) (n = 30 of each) i.v. immediately after clamping of the foetal umbilical cord. Nausea, vomiting and safety assessments were performed during and after spinal anaesthesia for caesarean section.

RESULTS

The incidence of intraoperative, post-delivery nausea and vomiting was 13%, 17%, 20% and 63% after administration of granisetron, droperidol, metoclopramide and placebo, respectively; the corresponding incidence during 0-3 h after surgery was 7%, 27%, 27% and 43%; the corresponding incidence during 3-24 h after surgery was 7%, 20%, 23% and 37% (P < 0.05; overall Fisher's exact probability test). No clinically important adverse events were observed in any of the groups.

CONCLUSION

Granisetron is highly effective for preventing nausea and vomiting during and after spinal anaesthesia for caesarean section. Droperidol and metoclopramide are effective for the prevention of intraoperative, post-delivery emesis, but are ineffective for the reduction of the incidence of postoperative emesis.

Authors+Show Affiliations

Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9773135

Citation

Fujii, Y, et al. "Prevention of Nausea and Vomiting With Granisetron, Droperidol and Metoclopramide During and After Spinal Anaesthesia for Caesarean Section: a Randomized, Double-blind, Placebo-controlled Trial." Acta Anaesthesiologica Scandinavica, vol. 42, no. 8, 1998, pp. 921-5.
Fujii Y, Tanaka H, Toyooka H. Prevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: a randomized, double-blind, placebo-controlled trial. Acta Anaesthesiol Scand. 1998;42(8):921-5.
Fujii, Y., Tanaka, H., & Toyooka, H. (1998). Prevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: a randomized, double-blind, placebo-controlled trial. Acta Anaesthesiologica Scandinavica, 42(8), 921-5.
Fujii Y, Tanaka H, Toyooka H. Prevention of Nausea and Vomiting With Granisetron, Droperidol and Metoclopramide During and After Spinal Anaesthesia for Caesarean Section: a Randomized, Double-blind, Placebo-controlled Trial. Acta Anaesthesiol Scand. 1998;42(8):921-5. PubMed PMID: 9773135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: a randomized, double-blind, placebo-controlled trial. AU - Fujii,Y, AU - Tanaka,H, AU - Toyooka,H, PY - 1998/10/17/pubmed PY - 1998/10/17/medline PY - 1998/10/17/entrez SP - 921 EP - 5 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 42 IS - 8 N2 - BACKGROUND: Nausea and vomiting during and after spinal anaesthesia for caesarean section are distressing to the patient. This study was undertaken to evaluate the efficacy and safety of granisetron, droperidol and metoclopramide for the prevention of nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia. METHODS: In a randomized, double-blind, placebo-controlled trial, 120 patients received granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg or placebo (saline) (n = 30 of each) i.v. immediately after clamping of the foetal umbilical cord. Nausea, vomiting and safety assessments were performed during and after spinal anaesthesia for caesarean section. RESULTS: The incidence of intraoperative, post-delivery nausea and vomiting was 13%, 17%, 20% and 63% after administration of granisetron, droperidol, metoclopramide and placebo, respectively; the corresponding incidence during 0-3 h after surgery was 7%, 27%, 27% and 43%; the corresponding incidence during 3-24 h after surgery was 7%, 20%, 23% and 37% (P < 0.05; overall Fisher's exact probability test). No clinically important adverse events were observed in any of the groups. CONCLUSION: Granisetron is highly effective for preventing nausea and vomiting during and after spinal anaesthesia for caesarean section. Droperidol and metoclopramide are effective for the prevention of intraoperative, post-delivery emesis, but are ineffective for the reduction of the incidence of postoperative emesis. SN - 0001-5172 UR - https://www.unboundmedicine.com/medline/citation/9773135/Prevention_of_nausea_and_vomiting_with_granisetron_droperidol_and_metoclopramide_during_and_after_spinal_anaesthesia_for_caesarean_section:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-5172&amp;date=1998&amp;volume=42&amp;issue=8&amp;spage=921 DB - PRIME DP - Unbound Medicine ER -