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Effect of two oral contraceptives containing ethinyl estradiol and gestodene or norgestimate on different lipid and lipoprotein parameters.
Contraception 1998; 58(2):83-91C

Abstract

The effect of a triphasic oral contraceptive containing ethinyl estradiol and gestodene (EE/GSD) on various lipid and lipoprotein parameters was compared with that of a monophasic formulation containing 35 micrograms ethinyl estradiol and 250 micrograms norgestimate (EE/NGM). Blood samples were collected from 46 women on days 2, 11, and 21 of the preceding control cycle and of the third, sixth, and twelfth treatment cycles. There was no significant difference between formulations with regard to the influence on any measured parameter. As compared with controls, a significant increase was observed in the plasma levels of total triglycerides (24-78%), total phospholipids (7-20%), very low density lipoprotein (VLDL) triglycerides (61-76%), VLDL-phospholipids (14-60%), low density lipoprotein (LDL) triglycerides (8-35%), LDL-phospholipids (28-30%), high density lipoprotein (HDL) cholesterol (8-16%), HDL 3-cholesterol (11-20%), HDL-triglycerides (17-66%), HDL-phospholipids, HDL 3-phospholipids (7-11%), apolipoprotein (apo) A-I (5-20%) and apo A-II (10-40%) during treatment with both formulations. In contrast, the LDL-cholesterol levels were significantly decreased. These changes in lipid metabolism appear to reflect a predominance of the effect of the estrogen component. The results indicate that both low dose oral contraceptives containing different progestins and different amounts of EE do not exert a deleterious effect on lipoprotein metabolism, as high HDL-cholesterol and low LDL-cholesterol levels are known as low risk factors of cardiovascular disease. In contrast to endogenous hypertriglyceridemia, an EE-induced rise in triglyceride levels does not appear to increase cardiovascular risk if LDL is not increased.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, J.W. Goethe-University, Frankfurt, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9773262

Citation

Wiegratz, I, et al. "Effect of Two Oral Contraceptives Containing Ethinyl Estradiol and Gestodene or Norgestimate On Different Lipid and Lipoprotein Parameters." Contraception, vol. 58, no. 2, 1998, pp. 83-91.
Wiegratz I, Jung-Hoffmann C, Gross W, et al. Effect of two oral contraceptives containing ethinyl estradiol and gestodene or norgestimate on different lipid and lipoprotein parameters. Contraception. 1998;58(2):83-91.
Wiegratz, I., Jung-Hoffmann, C., Gross, W., & Kuhl, H. (1998). Effect of two oral contraceptives containing ethinyl estradiol and gestodene or norgestimate on different lipid and lipoprotein parameters. Contraception, 58(2), pp. 83-91.
Wiegratz I, et al. Effect of Two Oral Contraceptives Containing Ethinyl Estradiol and Gestodene or Norgestimate On Different Lipid and Lipoprotein Parameters. Contraception. 1998;58(2):83-91. PubMed PMID: 9773262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of two oral contraceptives containing ethinyl estradiol and gestodene or norgestimate on different lipid and lipoprotein parameters. AU - Wiegratz,I, AU - Jung-Hoffmann,C, AU - Gross,W, AU - Kuhl,H, PY - 1998/10/17/pubmed PY - 1998/10/17/medline PY - 1998/10/17/entrez KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents, Estrogen--pharmacodynamics KW - Contraceptive Agents, Female--pharmacodynamics KW - Contraceptive Agents, Progestin--pharmacodynamics KW - Contraceptive Agents--pharmacodynamics KW - Contraceptive Methods--pharmacodynamics KW - Developed Countries KW - Ethinyl Estradiol--pharmacodynamics KW - Europe KW - Family Planning KW - Germany KW - Gestodene--pharmacodynamics KW - Lipid Metabolic Effects KW - Lipids KW - Norgestimate--pharmacodynamics KW - Oral Contraceptives, Combined--pharmacodynamics KW - Oral Contraceptives--pharmacodynamics KW - Physiology KW - Research Methodology KW - Research Report KW - Western Europe SP - 83 EP - 91 JF - Contraception JO - Contraception VL - 58 IS - 2 N2 - The effect of a triphasic oral contraceptive containing ethinyl estradiol and gestodene (EE/GSD) on various lipid and lipoprotein parameters was compared with that of a monophasic formulation containing 35 micrograms ethinyl estradiol and 250 micrograms norgestimate (EE/NGM). Blood samples were collected from 46 women on days 2, 11, and 21 of the preceding control cycle and of the third, sixth, and twelfth treatment cycles. There was no significant difference between formulations with regard to the influence on any measured parameter. As compared with controls, a significant increase was observed in the plasma levels of total triglycerides (24-78%), total phospholipids (7-20%), very low density lipoprotein (VLDL) triglycerides (61-76%), VLDL-phospholipids (14-60%), low density lipoprotein (LDL) triglycerides (8-35%), LDL-phospholipids (28-30%), high density lipoprotein (HDL) cholesterol (8-16%), HDL 3-cholesterol (11-20%), HDL-triglycerides (17-66%), HDL-phospholipids, HDL 3-phospholipids (7-11%), apolipoprotein (apo) A-I (5-20%) and apo A-II (10-40%) during treatment with both formulations. In contrast, the LDL-cholesterol levels were significantly decreased. These changes in lipid metabolism appear to reflect a predominance of the effect of the estrogen component. The results indicate that both low dose oral contraceptives containing different progestins and different amounts of EE do not exert a deleterious effect on lipoprotein metabolism, as high HDL-cholesterol and low LDL-cholesterol levels are known as low risk factors of cardiovascular disease. In contrast to endogenous hypertriglyceridemia, an EE-induced rise in triglyceride levels does not appear to increase cardiovascular risk if LDL is not increased. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/9773262/Effect_of_two_oral_contraceptives_containing_ethinyl_estradiol_and_gestodene_or_norgestimate_on_different_lipid_and_lipoprotein_parameters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(98)00074-2 DB - PRIME DP - Unbound Medicine ER -