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[Intestinal permeability in the first year of life. The effect of diarrhea].
An Esp Pediatr. 1998 Aug; 49(2):125-8.AE

Abstract

OBJECTIVE

The permeability of the intestinal mucosa to lactulose and mannitol was explored longitudinally in infants at 1, 3-4 and 11-12 months of age. This was also evaluated during the episodes of diarrhea that they suffered during follow-up.

PATIENTS AND METHODS

Sugar excretion was measured by gas chromatography in five-hour urine samples.

RESULTS

A decrease in lactulose excretion was observed, which became significant at 11-12 months of age (p = 0.02). No changes were detected in mannitol excretion, although this showed a tendency to decrease. The lactulose/mannitol (L/M) ratio remained unchanged. During the 15 episodes of diarrhea observed in these infants during the 12 month follow-up, a considerable increase in this ratio was seen, due mainly to increased lactulose excretion.

CONCLUSIONS

It is hypothesized that the decrease in lactulose excretion between one and 11-12 months of age is part of the maturational process of the intestinal barrier, while diarrhea results in increased permeability due to damage to the absorptive epithelium.

Authors+Show Affiliations

Unidad de Gastroenterología, Universidad de Chile, Santiago, Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

9773545

Citation

Gotteland, M, et al. "[Intestinal Permeability in the First Year of Life. the Effect of Diarrhea]." Anales Espanoles De Pediatria, vol. 49, no. 2, 1998, pp. 125-8.
Gotteland M, Cruchet Muñoz S, Araya Quezada M, et al. [Intestinal permeability in the first year of life. The effect of diarrhea]. An Esp Pediatr. 1998;49(2):125-8.
Gotteland, M., Cruchet Muñoz, S., Araya Quezada, M., Espinoza Madariaga, J., & Brunser Tesarschü, O. (1998). [Intestinal permeability in the first year of life. The effect of diarrhea]. Anales Espanoles De Pediatria, 49(2), 125-8.
Gotteland M, et al. [Intestinal Permeability in the First Year of Life. the Effect of Diarrhea]. An Esp Pediatr. 1998;49(2):125-8. PubMed PMID: 9773545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intestinal permeability in the first year of life. The effect of diarrhea]. AU - Gotteland,M, AU - Cruchet Muñoz,S, AU - Araya Quezada,M, AU - Espinoza Madariaga,J, AU - Brunser Tesarschü,O, PY - 1998/10/17/pubmed PY - 1998/10/17/medline PY - 1998/10/17/entrez SP - 125 EP - 8 JF - Anales espanoles de pediatria JO - An. Esp. Pediatr. VL - 49 IS - 2 N2 - OBJECTIVE: The permeability of the intestinal mucosa to lactulose and mannitol was explored longitudinally in infants at 1, 3-4 and 11-12 months of age. This was also evaluated during the episodes of diarrhea that they suffered during follow-up. PATIENTS AND METHODS: Sugar excretion was measured by gas chromatography in five-hour urine samples. RESULTS: A decrease in lactulose excretion was observed, which became significant at 11-12 months of age (p = 0.02). No changes were detected in mannitol excretion, although this showed a tendency to decrease. The lactulose/mannitol (L/M) ratio remained unchanged. During the 15 episodes of diarrhea observed in these infants during the 12 month follow-up, a considerable increase in this ratio was seen, due mainly to increased lactulose excretion. CONCLUSIONS: It is hypothesized that the decrease in lactulose excretion between one and 11-12 months of age is part of the maturational process of the intestinal barrier, while diarrhea results in increased permeability due to damage to the absorptive epithelium. SN - 0302-4342 UR - https://www.unboundmedicine.com/medline/citation/9773545/[Intestinal_permeability_in_the_first_year_of_life__The_effect_of_diarrhea]_ L2 - http://www.diseaseinfosearch.org/result/2258 DB - PRIME DP - Unbound Medicine ER -