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Lichen sclerosus. Therapy with clobetasol propionate.
J Reprod Med. 1998 Sep; 43(9):790-4.JR

Abstract

OBJECTIVE

To assess the efficacy of treating lichen sclerosus with clobetasol propionate.

STUDY DESIGN

A retrospective chart review of 81 consecutive symptomatic private practice and clinic patients with biopsy-proven lichen sclerosus were included. All subjects' punch biopsies, baseline histories and physical examinations were reviewed by the same examiner. Each subject's symptomatology and responses to previous treatment modalities were recorded. A standard regimen of 0.05% clobetasol propionate cream was initiated. Subjects were reevaluated at three months and asked to rate the improvement of symptoms. Follow-up examinations were conducted 6-12 months later on 36 subjects. Descriptive statistics and chi 2 analyses were performed.

RESULTS

The mean age of subjects was 54 +/- 15.5 years (range, 15-86), and the average duration of treatment prior to clobetasol use was 6 +/- 6.9 years (range, 0.5-29). Twenty-seven subjects did not complete the study or were lost to follow-up. The average subject had tried 2.25 treatment modalities (range, 1-13). The most common symptoms were pruritus (98%) and irritation (61%), with complaints of burning and dyspareunia. Most subjects (76%) had labial involvement, with concomitant involvement of the clitoris (70%), perineum (68%) and perianus (32%). The majority (88%) of subjects had a primary lesion of white and crinkled tissue. With clobetasol, 77% of subjects had complete remission of symptoms, 18% had partial remission and 5% reported no change. A change in clinical appearance was noted for the complete-remission (32%) and partial-remission groups (46%). Twenty-two percent revealed no change.

CONCLUSION

Clobetasol propionate cream is recommended for treatment of lichen sclerosus, with a 77% chance of complete remission of symptoms and a 47% chance of improvement in the clinical appearance of the vulva. Women may have to continue to use clobetasol as needed after finishing a base treatment course.

Authors+Show Affiliations

Lorenz B
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA.
Kaufman RH
No affiliation info available
Kutzner SK
No affiliation info available

MeSH

Administration, TopicalAdolescentAdultAgedAged, 80 and overAnti-Inflammatory AgentsClobetasolDyspareuniaFemaleGlucocorticoidsHumansLichen Sclerosus et AtrophicusMiddle AgedPruritusRetrospective StudiesTreatment OutcomeVulvar Diseases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9777618

Citation

Lorenz, B, et al. "Lichen Sclerosus. Therapy With Clobetasol Propionate." The Journal of Reproductive Medicine, vol. 43, no. 9, 1998, pp. 790-4.
Lorenz B, Kaufman RH, Kutzner SK. Lichen sclerosus. Therapy with clobetasol propionate. J Reprod Med. 1998;43(9):790-4.
Lorenz, B., Kaufman, R. H., & Kutzner, S. K. (1998). Lichen sclerosus. Therapy with clobetasol propionate. The Journal of Reproductive Medicine, 43(9), 790-4.
Lorenz B, Kaufman RH, Kutzner SK. Lichen Sclerosus. Therapy With Clobetasol Propionate. J Reprod Med. 1998;43(9):790-4. PubMed PMID: 9777618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lichen sclerosus. Therapy with clobetasol propionate. AU - Lorenz,B, AU - Kaufman,R H, AU - Kutzner,S K, PY - 1998/10/20/pubmed PY - 1998/10/20/medline PY - 1998/10/20/entrez SP - 790 EP - 4 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 43 IS - 9 N2 - OBJECTIVE: To assess the efficacy of treating lichen sclerosus with clobetasol propionate. STUDY DESIGN: A retrospective chart review of 81 consecutive symptomatic private practice and clinic patients with biopsy-proven lichen sclerosus were included. All subjects' punch biopsies, baseline histories and physical examinations were reviewed by the same examiner. Each subject's symptomatology and responses to previous treatment modalities were recorded. A standard regimen of 0.05% clobetasol propionate cream was initiated. Subjects were reevaluated at three months and asked to rate the improvement of symptoms. Follow-up examinations were conducted 6-12 months later on 36 subjects. Descriptive statistics and chi 2 analyses were performed. RESULTS: The mean age of subjects was 54 +/- 15.5 years (range, 15-86), and the average duration of treatment prior to clobetasol use was 6 +/- 6.9 years (range, 0.5-29). Twenty-seven subjects did not complete the study or were lost to follow-up. The average subject had tried 2.25 treatment modalities (range, 1-13). The most common symptoms were pruritus (98%) and irritation (61%), with complaints of burning and dyspareunia. Most subjects (76%) had labial involvement, with concomitant involvement of the clitoris (70%), perineum (68%) and perianus (32%). The majority (88%) of subjects had a primary lesion of white and crinkled tissue. With clobetasol, 77% of subjects had complete remission of symptoms, 18% had partial remission and 5% reported no change. A change in clinical appearance was noted for the complete-remission (32%) and partial-remission groups (46%). Twenty-two percent revealed no change. CONCLUSION: Clobetasol propionate cream is recommended for treatment of lichen sclerosus, with a 77% chance of complete remission of symptoms and a 47% chance of improvement in the clinical appearance of the vulva. Women may have to continue to use clobetasol as needed after finishing a base treatment course. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/9777618/Lichen_sclerosus__Therapy_with_clobetasol_propionate_ L2 - https://medlineplus.gov/vulvardisorders.html DB - PRIME DP - Unbound Medicine ER -