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Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats.
Lipids. 1998 Sep; 33(9):897-904.L

Abstract

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were distributed mainly in the sn-1,3 positions of seal oil triglyceride and in the sn-2 position of squid oil triglyceride. Seal oil-rich or squid oil-rich fats having constant saturated/monounsaturated/polyunsaturated fatty acid (PUFA) and n-6/n-3 PUFA ratios were fed to exogenously hypercholesterolemic rats for 1 60 d. The control fat contained linoleic acid as the sole PUFA. Before starting the experimental diets, rats were orally treated with high doses of vitamin D for 4 d to accelerate atherogenesis. The percentage of arachidonic acid in phosphatidylcholine and phosphatidylethanolamine of liver, platelets, and aorta was lower in the marine oil groups than in the control group, seal oil being more effective than squid oil. Maximal platelet aggregation induced by collagen was significantly lower in both marine oil groups. Platelet thromboxane (TX) A2 production induced by collagen or thrombin was markedly reduced by feeding seal or squid oils, the reduction being more pronounced in the seal oil than in the squid oil group. Aortic prostacyclin (PGI2) production was the same among the three groups. The ratio of the productions of aortic PGI2 and platelet TXA2 was significantly higher in the seal oil than in the control group. Although there was no difference in intimal thickness among the three groups, the aortic cholesterol content was significantly lower in the marine oil groups than in the control group. These results showed that the main effects in rats of the different intramolecular distributions of EPA and DHA in dietary fats were on arachidonic acid content in tissue phospholipids and on platelet TXA2 production.

Authors+Show Affiliations

Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan. iikeda@agr.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9778137

Citation

Ikeda, I, et al. "Effects of Long-term Feeding of Marine Oils With Different Positional Distribution of Eicosapentaenoic and Docosahexaenoic Acids On Lipid Metabolism, Eicosanoid Production, and Platelet Aggregation in Hypercholesterolemic Rats." Lipids, vol. 33, no. 9, 1998, pp. 897-904.
Ikeda I, Yoshida H, Tomooka M, et al. Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. Lipids. 1998;33(9):897-904.
Ikeda, I., Yoshida, H., Tomooka, M., Yosef, A., Imaizumi, K., Tsuji, H., & Seto, A. (1998). Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. Lipids, 33(9), 897-904.
Ikeda I, et al. Effects of Long-term Feeding of Marine Oils With Different Positional Distribution of Eicosapentaenoic and Docosahexaenoic Acids On Lipid Metabolism, Eicosanoid Production, and Platelet Aggregation in Hypercholesterolemic Rats. Lipids. 1998;33(9):897-904. PubMed PMID: 9778137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. AU - Ikeda,I, AU - Yoshida,H, AU - Tomooka,M, AU - Yosef,A, AU - Imaizumi,K, AU - Tsuji,H, AU - Seto,A, PY - 1998/10/20/pubmed PY - 1998/10/20/medline PY - 1998/10/20/entrez SP - 897 EP - 904 JF - Lipids JO - Lipids VL - 33 IS - 9 N2 - Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were distributed mainly in the sn-1,3 positions of seal oil triglyceride and in the sn-2 position of squid oil triglyceride. Seal oil-rich or squid oil-rich fats having constant saturated/monounsaturated/polyunsaturated fatty acid (PUFA) and n-6/n-3 PUFA ratios were fed to exogenously hypercholesterolemic rats for 1 60 d. The control fat contained linoleic acid as the sole PUFA. Before starting the experimental diets, rats were orally treated with high doses of vitamin D for 4 d to accelerate atherogenesis. The percentage of arachidonic acid in phosphatidylcholine and phosphatidylethanolamine of liver, platelets, and aorta was lower in the marine oil groups than in the control group, seal oil being more effective than squid oil. Maximal platelet aggregation induced by collagen was significantly lower in both marine oil groups. Platelet thromboxane (TX) A2 production induced by collagen or thrombin was markedly reduced by feeding seal or squid oils, the reduction being more pronounced in the seal oil than in the squid oil group. Aortic prostacyclin (PGI2) production was the same among the three groups. The ratio of the productions of aortic PGI2 and platelet TXA2 was significantly higher in the seal oil than in the control group. Although there was no difference in intimal thickness among the three groups, the aortic cholesterol content was significantly lower in the marine oil groups than in the control group. These results showed that the main effects in rats of the different intramolecular distributions of EPA and DHA in dietary fats were on arachidonic acid content in tissue phospholipids and on platelet TXA2 production. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/9778137/Effects_of_long_term_feeding_of_marine_oils_with_different_positional_distribution_of_eicosapentaenoic_and_docosahexaenoic_acids_on_lipid_metabolism_eicosanoid_production_and_platelet_aggregation_in_hypercholesterolemic_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1998&volume=33&issue=9&spage=897 DB - PRIME DP - Unbound Medicine ER -