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Cytokine production after influenza vaccination in a healthy elderly population.
Vaccine 1998; 16(18):1722-31V

Abstract

Influenza vaccination is less efficacious in the elderly than in the young. To characterize this age-related decrease in immune response to influenza vaccination, antibody and cell-mediated responses to influenza vaccine were assessed before immunization and 4 weeks after vaccination of a population of 270 healthy elderly individuals (mean age: 80.2 years) living in eight local continuing care retirement communities (CCRCs) and 30 young individuals (mean age: 27.8 years). The antibody titres produced against all three influenza strains increased significantly after vaccination in both the young and elderly (p < 0.0005); however, the young demonstrated significantly higher titres to all three strains than did the elderly (p < 0.03). Peripheral blood mononuclear cells (PBMC) cultured with influenza vaccine demonstrated significantly increased proliferation (elderly: p < 0.00005; young: p < 0.001) after vaccination, with proliferative responses in the young significantly higher than the elderly both before (p < 0.04) and after (p < 0.0005) vaccination. Similarly, IFN gamma production in these PBMC cultures increased significantly pre- to postvaccination in both young and elderly (young: p < 0.006; elderly: p < 0.00005), but the young produced more than the elderly both pre- and postvaccination (p < 0.0001). Following vaccination, PBMC production of IL-10 was higher in the young than in the elderly (p < 0.0015), while IL-6 production was comparable in both young and elderly individuals. Greater than 13% of the elderly population did not produce detectable IL-6, IL-10, or IFN gamma either before or after vaccination. The data show that the decreased cell-mediated and humoral responses to influenza vaccination of this healthy elderly population are accompanied by the production of lower levels of cytokines. A unique finding in this population of 270 healthy elderly was the association between a TH0 cytokine profile and intact immune responses to influenza vaccine. A similar relationship was not seen in the young.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9778748

Citation

Bernstein, E D., et al. "Cytokine Production After Influenza Vaccination in a Healthy Elderly Population." Vaccine, vol. 16, no. 18, 1998, pp. 1722-31.
Bernstein ED, Gardner EM, Abrutyn E, et al. Cytokine production after influenza vaccination in a healthy elderly population. Vaccine. 1998;16(18):1722-31.
Bernstein, E. D., Gardner, E. M., Abrutyn, E., Gross, P., & Murasko, D. M. (1998). Cytokine production after influenza vaccination in a healthy elderly population. Vaccine, 16(18), pp. 1722-31.
Bernstein ED, et al. Cytokine Production After Influenza Vaccination in a Healthy Elderly Population. Vaccine. 1998;16(18):1722-31. PubMed PMID: 9778748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokine production after influenza vaccination in a healthy elderly population. AU - Bernstein,E D, AU - Gardner,E M, AU - Abrutyn,E, AU - Gross,P, AU - Murasko,D M, PY - 1998/10/21/pubmed PY - 1998/10/21/medline PY - 1998/10/21/entrez SP - 1722 EP - 31 JF - Vaccine JO - Vaccine VL - 16 IS - 18 N2 - Influenza vaccination is less efficacious in the elderly than in the young. To characterize this age-related decrease in immune response to influenza vaccination, antibody and cell-mediated responses to influenza vaccine were assessed before immunization and 4 weeks after vaccination of a population of 270 healthy elderly individuals (mean age: 80.2 years) living in eight local continuing care retirement communities (CCRCs) and 30 young individuals (mean age: 27.8 years). The antibody titres produced against all three influenza strains increased significantly after vaccination in both the young and elderly (p < 0.0005); however, the young demonstrated significantly higher titres to all three strains than did the elderly (p < 0.03). Peripheral blood mononuclear cells (PBMC) cultured with influenza vaccine demonstrated significantly increased proliferation (elderly: p < 0.00005; young: p < 0.001) after vaccination, with proliferative responses in the young significantly higher than the elderly both before (p < 0.04) and after (p < 0.0005) vaccination. Similarly, IFN gamma production in these PBMC cultures increased significantly pre- to postvaccination in both young and elderly (young: p < 0.006; elderly: p < 0.00005), but the young produced more than the elderly both pre- and postvaccination (p < 0.0001). Following vaccination, PBMC production of IL-10 was higher in the young than in the elderly (p < 0.0015), while IL-6 production was comparable in both young and elderly individuals. Greater than 13% of the elderly population did not produce detectable IL-6, IL-10, or IFN gamma either before or after vaccination. The data show that the decreased cell-mediated and humoral responses to influenza vaccination of this healthy elderly population are accompanied by the production of lower levels of cytokines. A unique finding in this population of 270 healthy elderly was the association between a TH0 cytokine profile and intact immune responses to influenza vaccine. A similar relationship was not seen in the young. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/9778748/Cytokine_production_after_influenza_vaccination_in_a_healthy_elderly_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(98)00140-6 DB - PRIME DP - Unbound Medicine ER -