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Cytokine production after influenza vaccination in a healthy elderly population.

Abstract

Influenza vaccination is less efficacious in the elderly than in the young. To characterize this age-related decrease in immune response to influenza vaccination, antibody and cell-mediated responses to influenza vaccine were assessed before immunization and 4 weeks after vaccination of a population of 270 healthy elderly individuals (mean age: 80.2 years) living in eight local continuing care retirement communities (CCRCs) and 30 young individuals (mean age: 27.8 years). The antibody titres produced against all three influenza strains increased significantly after vaccination in both the young and elderly (p < 0.0005); however, the young demonstrated significantly higher titres to all three strains than did the elderly (p < 0.03). Peripheral blood mononuclear cells (PBMC) cultured with influenza vaccine demonstrated significantly increased proliferation (elderly: p < 0.00005; young: p < 0.001) after vaccination, with proliferative responses in the young significantly higher than the elderly both before (p < 0.04) and after (p < 0.0005) vaccination. Similarly, IFN gamma production in these PBMC cultures increased significantly pre- to postvaccination in both young and elderly (young: p < 0.006; elderly: p < 0.00005), but the young produced more than the elderly both pre- and postvaccination (p < 0.0001). Following vaccination, PBMC production of IL-10 was higher in the young than in the elderly (p < 0.0015), while IL-6 production was comparable in both young and elderly individuals. Greater than 13% of the elderly population did not produce detectable IL-6, IL-10, or IFN gamma either before or after vaccination. The data show that the decreased cell-mediated and humoral responses to influenza vaccination of this healthy elderly population are accompanied by the production of lower levels of cytokines. A unique finding in this population of 270 healthy elderly was the association between a TH0 cytokine profile and intact immune responses to influenza vaccine. A similar relationship was not seen in the young.

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  • Authors

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    Source

    Vaccine 16:18 1998 Nov pg 1722-31

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Antibodies, Viral
    Cell Division
    Cytokines
    Female
    Humans
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Male
    Middle Aged
    Monocytes
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9778748

    Citation

    Bernstein, E D., et al. "Cytokine Production After Influenza Vaccination in a Healthy Elderly Population." Vaccine, vol. 16, no. 18, 1998, pp. 1722-31.
    Bernstein ED, Gardner EM, Abrutyn E, et al. Cytokine production after influenza vaccination in a healthy elderly population. Vaccine. 1998;16(18):1722-31.
    Bernstein, E. D., Gardner, E. M., Abrutyn, E., Gross, P., & Murasko, D. M. (1998). Cytokine production after influenza vaccination in a healthy elderly population. Vaccine, 16(18), pp. 1722-31.
    Bernstein ED, et al. Cytokine Production After Influenza Vaccination in a Healthy Elderly Population. Vaccine. 1998;16(18):1722-31. PubMed PMID: 9778748.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cytokine production after influenza vaccination in a healthy elderly population. AU - Bernstein,E D, AU - Gardner,E M, AU - Abrutyn,E, AU - Gross,P, AU - Murasko,D M, PY - 1998/10/21/pubmed PY - 1998/10/21/medline PY - 1998/10/21/entrez SP - 1722 EP - 31 JF - Vaccine JO - Vaccine VL - 16 IS - 18 N2 - Influenza vaccination is less efficacious in the elderly than in the young. To characterize this age-related decrease in immune response to influenza vaccination, antibody and cell-mediated responses to influenza vaccine were assessed before immunization and 4 weeks after vaccination of a population of 270 healthy elderly individuals (mean age: 80.2 years) living in eight local continuing care retirement communities (CCRCs) and 30 young individuals (mean age: 27.8 years). The antibody titres produced against all three influenza strains increased significantly after vaccination in both the young and elderly (p < 0.0005); however, the young demonstrated significantly higher titres to all three strains than did the elderly (p < 0.03). Peripheral blood mononuclear cells (PBMC) cultured with influenza vaccine demonstrated significantly increased proliferation (elderly: p < 0.00005; young: p < 0.001) after vaccination, with proliferative responses in the young significantly higher than the elderly both before (p < 0.04) and after (p < 0.0005) vaccination. Similarly, IFN gamma production in these PBMC cultures increased significantly pre- to postvaccination in both young and elderly (young: p < 0.006; elderly: p < 0.00005), but the young produced more than the elderly both pre- and postvaccination (p < 0.0001). Following vaccination, PBMC production of IL-10 was higher in the young than in the elderly (p < 0.0015), while IL-6 production was comparable in both young and elderly individuals. Greater than 13% of the elderly population did not produce detectable IL-6, IL-10, or IFN gamma either before or after vaccination. The data show that the decreased cell-mediated and humoral responses to influenza vaccination of this healthy elderly population are accompanied by the production of lower levels of cytokines. A unique finding in this population of 270 healthy elderly was the association between a TH0 cytokine profile and intact immune responses to influenza vaccine. A similar relationship was not seen in the young. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/9778748/Cytokine_production_after_influenza_vaccination_in_a_healthy_elderly_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(98)00140-6 DB - PRIME DP - Unbound Medicine ER -