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Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis.
Ann Clin Psychiatry 1998; 10(3):101-5AC

Abstract

Tardive dyskinesia is an involuntary movement disorder developing following treatment with neuroleptics. As many as 50% of chronic psychotic patients develop this disabling condition. No treatment has been found effective for tardive dyskinesia. This study was undertaken to meta-analyze the effects of vitamin E (alpha-tocopherol) reported in the last decade. All studies published since 1987, focusing on vitamin E and tardive dyskinesia are reviewed. Double-blind studies are analyzed using measures of effect and variance as described by secondary analysis of magnitude of effects in pooled data. A total of 223 patients received vitamin E treatment (400-1600 IU/day) for tardive dyskinesia, in 12 studies. A significant subgroup (28.3%) showed a modest improvement. Vitamin E was well tolerated, and only rarely did side effects occur-of no clinical significance. Vitamin E is a safe, well-tolerated compound that may provide some beneficial effects in patients suffering from neuroleptic-induced tardive dyskinesia.

Authors+Show Affiliations

Abarbanel Mental Health Center, Bat-Yam, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

9781472

Citation

Barak, Y, et al. "Vitamin E (alpha-tocopherol) in the Treatment of Tardive Dyskinesia: a Statistical Meta-analysis." Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists, vol. 10, no. 3, 1998, pp. 101-5.
Barak Y, Swartz M, Shamir E, et al. Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis. Ann Clin Psychiatry. 1998;10(3):101-5.
Barak, Y., Swartz, M., Shamir, E., Stein, D., & Weizman, A. (1998). Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis. Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists, 10(3), pp. 101-5.
Barak Y, et al. Vitamin E (alpha-tocopherol) in the Treatment of Tardive Dyskinesia: a Statistical Meta-analysis. Ann Clin Psychiatry. 1998;10(3):101-5. PubMed PMID: 9781472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis. AU - Barak,Y, AU - Swartz,M, AU - Shamir,E, AU - Stein,D, AU - Weizman,A, PY - 1998/10/22/pubmed PY - 1998/10/22/medline PY - 1998/10/22/entrez SP - 101 EP - 5 JF - Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists JO - Ann Clin Psychiatry VL - 10 IS - 3 N2 - Tardive dyskinesia is an involuntary movement disorder developing following treatment with neuroleptics. As many as 50% of chronic psychotic patients develop this disabling condition. No treatment has been found effective for tardive dyskinesia. This study was undertaken to meta-analyze the effects of vitamin E (alpha-tocopherol) reported in the last decade. All studies published since 1987, focusing on vitamin E and tardive dyskinesia are reviewed. Double-blind studies are analyzed using measures of effect and variance as described by secondary analysis of magnitude of effects in pooled data. A total of 223 patients received vitamin E treatment (400-1600 IU/day) for tardive dyskinesia, in 12 studies. A significant subgroup (28.3%) showed a modest improvement. Vitamin E was well tolerated, and only rarely did side effects occur-of no clinical significance. Vitamin E is a safe, well-tolerated compound that may provide some beneficial effects in patients suffering from neuroleptic-induced tardive dyskinesia. SN - 1040-1237 UR - https://www.unboundmedicine.com/medline/citation/9781472/Vitamin_E__alpha_tocopherol__in_the_treatment_of_tardive_dyskinesia:_a_statistical_meta_analysis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9781472.ui DB - PRIME DP - Unbound Medicine ER -