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Prevalence patterns and genotypes of GB virus C/hepatitis G virus among imprisoned intravenous drug users.
J Med Virol. 1998 Nov; 56(3):246-52.JM

Abstract

An RT-PCR assay using primers from the 5'-UTR of the GBV-C/HGV genome was used to detect viremia, and a serological assay was used to detect past exposure to GBV-C/HGV, in sera from 106 imprisoned Greek intravenous drug users. High seroprevalence rates indicative of the parenteral route of transmission of the virus were found (32.1% for GBV-C RNA and 46.2% for anti-GBV-C E2). These rates were nonetheless lower in comparison to the corresponding rates of HCV infection markers (64.2% for HCV RNA and 77.4% for anti-HCV). Statistically significant univariate associations were observed between GBV-C-RNA positivity and younger age (P=0.006) and HCV-RNA positivity (P=0.024), as well as with higher serum alanine aminotransferase levels (P< 0.001); this latter association was shown to be independent of coinfection with HCV and of age by a multiple logistic regression model. Apparently, GBV-C/HGV had spread readily by needle-sharing in prison, while causing acute subclinical hepatitis in infected inmates. Phylogenetic analysis of the partial 5'-UTR of the GBV-C/HGV genome from 16 seropositive individuals, which delineated their grouping within genotype 2, also revealed a close genetic relationship between two sets of sequences from 4 drug addicts, 3 of whom admitted to sharing needles while imprisoned.

Authors+Show Affiliations

Department of Hygiene and Epidemiology, Athens University Medical School, Goudi, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9783693

Citation

Anastassopoulou, C G., et al. "Prevalence Patterns and Genotypes of GB Virus C/hepatitis G Virus Among Imprisoned Intravenous Drug Users." Journal of Medical Virology, vol. 56, no. 3, 1998, pp. 246-52.
Anastassopoulou CG, Paraskevis D, Sypsa V, et al. Prevalence patterns and genotypes of GB virus C/hepatitis G virus among imprisoned intravenous drug users. J Med Virol. 1998;56(3):246-52.
Anastassopoulou, C. G., Paraskevis, D., Sypsa, V., Psichogiou, M., Katsoulidou, A., Tassopoulos, N., Skoutelis, A., Malliori, M., & Hatzakis, A. (1998). Prevalence patterns and genotypes of GB virus C/hepatitis G virus among imprisoned intravenous drug users. Journal of Medical Virology, 56(3), 246-52.
Anastassopoulou CG, et al. Prevalence Patterns and Genotypes of GB Virus C/hepatitis G Virus Among Imprisoned Intravenous Drug Users. J Med Virol. 1998;56(3):246-52. PubMed PMID: 9783693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence patterns and genotypes of GB virus C/hepatitis G virus among imprisoned intravenous drug users. AU - Anastassopoulou,C G, AU - Paraskevis,D, AU - Sypsa,V, AU - Psichogiou,M, AU - Katsoulidou,A, AU - Tassopoulos,N, AU - Skoutelis,A, AU - Malliori,M, AU - Hatzakis,A, PY - 1998/10/23/pubmed PY - 2000/6/20/medline PY - 1998/10/23/entrez SP - 246 EP - 52 JF - Journal of medical virology JO - J Med Virol VL - 56 IS - 3 N2 - An RT-PCR assay using primers from the 5'-UTR of the GBV-C/HGV genome was used to detect viremia, and a serological assay was used to detect past exposure to GBV-C/HGV, in sera from 106 imprisoned Greek intravenous drug users. High seroprevalence rates indicative of the parenteral route of transmission of the virus were found (32.1% for GBV-C RNA and 46.2% for anti-GBV-C E2). These rates were nonetheless lower in comparison to the corresponding rates of HCV infection markers (64.2% for HCV RNA and 77.4% for anti-HCV). Statistically significant univariate associations were observed between GBV-C-RNA positivity and younger age (P=0.006) and HCV-RNA positivity (P=0.024), as well as with higher serum alanine aminotransferase levels (P< 0.001); this latter association was shown to be independent of coinfection with HCV and of age by a multiple logistic regression model. Apparently, GBV-C/HGV had spread readily by needle-sharing in prison, while causing acute subclinical hepatitis in infected inmates. Phylogenetic analysis of the partial 5'-UTR of the GBV-C/HGV genome from 16 seropositive individuals, which delineated their grouping within genotype 2, also revealed a close genetic relationship between two sets of sequences from 4 drug addicts, 3 of whom admitted to sharing needles while imprisoned. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/9783693/Prevalence_patterns_and_genotypes_of_GB_virus_C/hepatitis_G_virus_among_imprisoned_intravenous_drug_users_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0146-6615&amp;date=1998&amp;volume=56&amp;issue=3&amp;spage=246 DB - PRIME DP - Unbound Medicine ER -