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New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus.
J Nat Prod. 1998 Oct; 61(10):1295-7.JN

Abstract

Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were determined to be 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1) and its cis isomer (2) by using spectroscopic, especially 2D NMR, data. A 3:1 mixture of 1 and 2 was shown to have potent in vitro activity against respiratory syncytial virus (EC50 2.46 microgram/mL, IC50 42.2 microgram/mL).

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Authors+Show Affiliations

Chen JL
Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080, USA.
Blanc P
No affiliation info available
Stoddart CA
No affiliation info available
Bogan M
No affiliation info available
Rozhon EJ
No affiliation info available
Parkinson N
No affiliation info available
Ye Z
No affiliation info available
Cooper R
No affiliation info available
Balick M
No affiliation info available
Nanakorn W
No affiliation info available
Kernan MR
No affiliation info available

MeSH

Antiviral AgentsCytopathogenic Effect, ViralGlycosidesMagnetic Resonance SpectroscopyPlants, MedicinalRespiratory Syncytial VirusesThailand

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9784173

Citation

Chen, J L., et al. "New Iridoids From the Medicinal Plant Barleria Prionitis With Potent Activity Against Respiratory Syncytial Virus." Journal of Natural Products, vol. 61, no. 10, 1998, pp. 1295-7.
Chen JL, Blanc P, Stoddart CA, et al. New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus. J Nat Prod. 1998;61(10):1295-7.
Chen, J. L., Blanc, P., Stoddart, C. A., Bogan, M., Rozhon, E. J., Parkinson, N., Ye, Z., Cooper, R., Balick, M., Nanakorn, W., & Kernan, M. R. (1998). New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus. Journal of Natural Products, 61(10), 1295-7.
Chen JL, et al. New Iridoids From the Medicinal Plant Barleria Prionitis With Potent Activity Against Respiratory Syncytial Virus. J Nat Prod. 1998;61(10):1295-7. PubMed PMID: 9784173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus. AU - Chen,J L, AU - Blanc,P, AU - Stoddart,C A, AU - Bogan,M, AU - Rozhon,E J, AU - Parkinson,N, AU - Ye,Z, AU - Cooper,R, AU - Balick,M, AU - Nanakorn,W, AU - Kernan,M R, PY - 1998/10/24/pubmed PY - 1998/10/24/medline PY - 1998/10/24/entrez SP - 1295 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 61 IS - 10 N2 - Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were determined to be 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1) and its cis isomer (2) by using spectroscopic, especially 2D NMR, data. A 3:1 mixture of 1 and 2 was shown to have potent in vitro activity against respiratory syncytial virus (EC50 2.46 microgram/mL, IC50 42.2 microgram/mL). SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/9784173/New_iridoids_from_the_medicinal_plant_Barleria_prionitis_with_potent_activity_against_respiratory_syncytial_virus_ L2 - https://doi.org/10.1021/np980086y DB - PRIME DP - Unbound Medicine ER -