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Human parvovirus B19: prevalence of viral DNA in volunteer blood donors and clinical outcomes of transfusion recipients.
Vox Sang. 1998; 75(2):97-102.VS

Abstract

BACKGROUND AND OBJECTIVES

Blood donor units are not screened for human parvovirus B19 (B19) even though it can be acquired via blood products. We estimated the prevalence of B19 in a US volunteer blood donor population and determined the clinical outcomes of transfusion recipients.

MATERIALS AND METHODS

Donor units were screened for B19 DNA by PCR, and positive units analyzed by EIA for B19 Ig. Unit usage was determined and recipient chart review conducted.

RESULTS

B19 DNA was detected in 11/9, 568 allogeneic units (0.1%), of which 3 had no measurable B19 Ig. One individual developed anemia consistent with B19 infection after receiving a DNA+ unit lacking B19 Ig.

CONCLUSIONS

The apparent low incidence of disease in patients transfused with B19 DNA+ components may be due to coexistence of neutralizing antibodies in donors and/or recipients.

Authors+Show Affiliations

Department of Pathology, Magee-Women's Research Institute, University of Pittsburgh, PA 15213, USA. jordanja+@pitt.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9784661

Citation

Jordan, J, et al. "Human Parvovirus B19: Prevalence of Viral DNA in Volunteer Blood Donors and Clinical Outcomes of Transfusion Recipients." Vox Sanguinis, vol. 75, no. 2, 1998, pp. 97-102.
Jordan J, Tiangco B, Kiss J, et al. Human parvovirus B19: prevalence of viral DNA in volunteer blood donors and clinical outcomes of transfusion recipients. Vox Sang. 1998;75(2):97-102.
Jordan, J., Tiangco, B., Kiss, J., & Koch, W. (1998). Human parvovirus B19: prevalence of viral DNA in volunteer blood donors and clinical outcomes of transfusion recipients. Vox Sanguinis, 75(2), 97-102.
Jordan J, et al. Human Parvovirus B19: Prevalence of Viral DNA in Volunteer Blood Donors and Clinical Outcomes of Transfusion Recipients. Vox Sang. 1998;75(2):97-102. PubMed PMID: 9784661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human parvovirus B19: prevalence of viral DNA in volunteer blood donors and clinical outcomes of transfusion recipients. AU - Jordan,J, AU - Tiangco,B, AU - Kiss,J, AU - Koch,W, PY - 1998/10/24/pubmed PY - 2000/8/16/medline PY - 1998/10/24/entrez SP - 97 EP - 102 JF - Vox sanguinis JO - Vox Sang VL - 75 IS - 2 N2 - BACKGROUND AND OBJECTIVES: Blood donor units are not screened for human parvovirus B19 (B19) even though it can be acquired via blood products. We estimated the prevalence of B19 in a US volunteer blood donor population and determined the clinical outcomes of transfusion recipients. MATERIALS AND METHODS: Donor units were screened for B19 DNA by PCR, and positive units analyzed by EIA for B19 Ig. Unit usage was determined and recipient chart review conducted. RESULTS: B19 DNA was detected in 11/9, 568 allogeneic units (0.1%), of which 3 had no measurable B19 Ig. One individual developed anemia consistent with B19 infection after receiving a DNA+ unit lacking B19 Ig. CONCLUSIONS: The apparent low incidence of disease in patients transfused with B19 DNA+ components may be due to coexistence of neutralizing antibodies in donors and/or recipients. SN - 0042-9007 UR - https://www.unboundmedicine.com/medline/citation/9784661/Human_parvovirus_B19:_prevalence_of_viral_DNA_in_volunteer_blood_donors_and_clinical_outcomes_of_transfusion_recipients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0042-9007&date=1998&volume=75&issue=2&spage=97 DB - PRIME DP - Unbound Medicine ER -