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Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation.

Abstract

The treatment of focal full thickness articular defects in the knee has continued to present a challenge, with no traditional treatment method providing consistent acceptable long-term clinical results. Patients with significant chondral defects frequently have persistent joint line pain, swelling, and catching in the knee. In contrast to marrow stimulation treatment techniques, such as abrasion arthroplasty, drilling, or microfracture which populate the defect with pluripotential stem cells, the use of cultured autologous chondrocytes fills the defect with cells of a committed pathway to develop hyaline-like cartilage. This hyaline-like cartilage more closely recreates the wear characteristics and durability of normal hyaline cartilage than the fibrous or fibrocartilage repair tissue formed by pluripotential stem cells. The purpose of this paper is to review the efficacy of available treatment options as well as the basic science rationale, indications, technique, postoperative rehabilitation, and clinical results of using cultured autologous chondrocytes in the treatment of focal full thickness chondral defects of the knee.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Atlanta Knee and Shoulder Clinic, Georgia Baptist Orthopaedic Residency Program 30327, USA.

    ,

    Source

    MeSH

    Arthroscopy
    Cartilage Diseases
    Cartilage, Articular
    Chondrocytes
    Debridement
    Exercise Therapy
    Humans
    Knee Injuries
    Knee Joint
    Osteoarthritis, Knee
    Stress, Mechanical
    Transplantation, Autologous
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    9785259

    Citation

    Gillogly, S D., et al. "Treatment of Articular Cartilage Defects of the Knee With Autologous Chondrocyte Implantation." The Journal of Orthopaedic and Sports Physical Therapy, vol. 28, no. 4, 1998, pp. 241-51.
    Gillogly SD, Voight M, Blackburn T. Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J Orthop Sports Phys Ther. 1998;28(4):241-51.
    Gillogly, S. D., Voight, M., & Blackburn, T. (1998). Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. The Journal of Orthopaedic and Sports Physical Therapy, 28(4), pp. 241-51.
    Gillogly SD, Voight M, Blackburn T. Treatment of Articular Cartilage Defects of the Knee With Autologous Chondrocyte Implantation. J Orthop Sports Phys Ther. 1998;28(4):241-51. PubMed PMID: 9785259.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. AU - Gillogly,S D, AU - Voight,M, AU - Blackburn,T, PY - 1998/10/24/pubmed PY - 1998/10/24/medline PY - 1998/10/24/entrez SP - 241 EP - 51 JF - The Journal of orthopaedic and sports physical therapy JO - J Orthop Sports Phys Ther VL - 28 IS - 4 N2 - The treatment of focal full thickness articular defects in the knee has continued to present a challenge, with no traditional treatment method providing consistent acceptable long-term clinical results. Patients with significant chondral defects frequently have persistent joint line pain, swelling, and catching in the knee. In contrast to marrow stimulation treatment techniques, such as abrasion arthroplasty, drilling, or microfracture which populate the defect with pluripotential stem cells, the use of cultured autologous chondrocytes fills the defect with cells of a committed pathway to develop hyaline-like cartilage. This hyaline-like cartilage more closely recreates the wear characteristics and durability of normal hyaline cartilage than the fibrous or fibrocartilage repair tissue formed by pluripotential stem cells. The purpose of this paper is to review the efficacy of available treatment options as well as the basic science rationale, indications, technique, postoperative rehabilitation, and clinical results of using cultured autologous chondrocytes in the treatment of focal full thickness chondral defects of the knee. SN - 0190-6011 UR - https://www.unboundmedicine.com/medline/citation/9785259/Treatment_of_articular_cartilage_defects_of_the_knee_with_autologous_chondrocyte_implantation_ L2 - http://www.jospt.org/doi/full/10.2519/jospt.1998.28.4.241?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -