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Treatment of antidepressant nonresponders: augmentation or switch?
J Clin Psychiatry 1998; 59 Suppl 15:35-41JC

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are now commonly used in the treatment of major depression. In all patients starting treatment, the intent-to-treat response rate is about 50%. The other 50% will require some change in treatment, either augmentation or switch to a different agent. In this report, augmentation strategies are reviewed, with special attention to those strategies that have been used with the SSRIs. The data for switching antidepressants also are reviewed. Although there are no direct comparison studies of augmentation strategies versus switching that address the question of relative efficacy, the tactical issues that pertain to augmentation or switching are discussed.

Authors+Show Affiliations

Yale University School of Medicine, New Haven, Conn, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9786309

Citation

Nelson, J C.. "Treatment of Antidepressant Nonresponders: Augmentation or Switch?" The Journal of Clinical Psychiatry, vol. 59 Suppl 15, 1998, pp. 35-41.
Nelson JC. Treatment of antidepressant nonresponders: augmentation or switch? J Clin Psychiatry. 1998;59 Suppl 15:35-41.
Nelson, J. C. (1998). Treatment of antidepressant nonresponders: augmentation or switch? The Journal of Clinical Psychiatry, 59 Suppl 15, pp. 35-41.
Nelson JC. Treatment of Antidepressant Nonresponders: Augmentation or Switch. J Clin Psychiatry. 1998;59 Suppl 15:35-41. PubMed PMID: 9786309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of antidepressant nonresponders: augmentation or switch? A1 - Nelson,J C, PY - 1998/10/24/pubmed PY - 1998/10/24/medline PY - 1998/10/24/entrez SP - 35 EP - 41 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 59 Suppl 15 N2 - Selective serotonin reuptake inhibitors (SSRIs) are now commonly used in the treatment of major depression. In all patients starting treatment, the intent-to-treat response rate is about 50%. The other 50% will require some change in treatment, either augmentation or switch to a different agent. In this report, augmentation strategies are reviewed, with special attention to those strategies that have been used with the SSRIs. The data for switching antidepressants also are reviewed. Although there are no direct comparison studies of augmentation strategies versus switching that address the question of relative efficacy, the tactical issues that pertain to augmentation or switching are discussed. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/9786309/Treatment_of_antidepressant_nonresponders:_augmentation_or_switch L2 - http://www.psychiatrist.com/jcp/article/pages/1998/v59s15/v59s1506.aspx DB - PRIME DP - Unbound Medicine ER -