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[Clinical utility of measurement for anti-GM1 and anti-GQ1b antibodies].
No To Shinkei. 1998 Sep; 50(9):849-53.NT

Abstract

Gangliosides, important constituents of the plasma membrane, are particularly abundant in the nervous system. Some patients develop Guillain-Barré syndrome after the administration of bovine brain gangliosides. We previously showed existence of molecular mimicry between GM1 ganglioside and lipopolysaccharide of Campylobacter jejuni isolated from the patients with Guillain-Barré syndrome, and that between GQ1b and C. jejuni isolated from Fisher's syndrome patients. Moreover, the anti-ganglioside antibody can cause motor nerve dysfunction in vitro. These support the pathogenic significance of anti-ganglioside antibodies. To clarify clinical utility of measurement for anti-GM1 and anti-GQ1b antibodies, we investigated sera from 429 patients with immunoneurological diseases included Fisher's syndrome, Bickerstaff's brainstem encephalitis, acute ophthalmoparesis, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and controls by enzyme-linked immunosorbent assay. We found very high titers of IgM anti-GM1 antibody in serum from a patient who had been diagnosed as having motor neuron disease. By further electrophysiological study, the patient was diagnosed as having multifocal motor neuropathy. Presence of high IgG anti-GM1 antibody titers was useful for supporting diagnosis of Guillain-Barré syndrome, IgG anti-GQ1b antibody was detected in patients who had paresis of extraocular muscles in Fisher's syndrome, Guillain-Barré syndrome, Bickerstaff's brainstem encephalitis, and acute ophthalmoparesis. This study showed that the measurement for anti-GM1 and anti-GQ1b antibodies are very useful.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

jpn

PubMed ID

9789308

Citation

Tagawa, Y, et al. "[Clinical Utility of Measurement for anti-GM1 and anti-GQ1b Antibodies]." No to Shinkei = Brain and Nerve, vol. 50, no. 9, 1998, pp. 849-53.
Tagawa Y, Matsumoto Y, Yuki N. [Clinical utility of measurement for anti-GM1 and anti-GQ1b antibodies]. No To Shinkei. 1998;50(9):849-53.
Tagawa, Y., Matsumoto, Y., & Yuki, N. (1998). [Clinical utility of measurement for anti-GM1 and anti-GQ1b antibodies]. No to Shinkei = Brain and Nerve, 50(9), 849-53.
Tagawa Y, Matsumoto Y, Yuki N. [Clinical Utility of Measurement for anti-GM1 and anti-GQ1b Antibodies]. No To Shinkei. 1998;50(9):849-53. PubMed PMID: 9789308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical utility of measurement for anti-GM1 and anti-GQ1b antibodies]. AU - Tagawa,Y, AU - Matsumoto,Y, AU - Yuki,N, PY - 1998/10/28/pubmed PY - 1998/10/28/medline PY - 1998/10/28/entrez SP - 849 EP - 53 JF - No to shinkei = Brain and nerve JO - No To Shinkei VL - 50 IS - 9 N2 - Gangliosides, important constituents of the plasma membrane, are particularly abundant in the nervous system. Some patients develop Guillain-Barré syndrome after the administration of bovine brain gangliosides. We previously showed existence of molecular mimicry between GM1 ganglioside and lipopolysaccharide of Campylobacter jejuni isolated from the patients with Guillain-Barré syndrome, and that between GQ1b and C. jejuni isolated from Fisher's syndrome patients. Moreover, the anti-ganglioside antibody can cause motor nerve dysfunction in vitro. These support the pathogenic significance of anti-ganglioside antibodies. To clarify clinical utility of measurement for anti-GM1 and anti-GQ1b antibodies, we investigated sera from 429 patients with immunoneurological diseases included Fisher's syndrome, Bickerstaff's brainstem encephalitis, acute ophthalmoparesis, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and controls by enzyme-linked immunosorbent assay. We found very high titers of IgM anti-GM1 antibody in serum from a patient who had been diagnosed as having motor neuron disease. By further electrophysiological study, the patient was diagnosed as having multifocal motor neuropathy. Presence of high IgG anti-GM1 antibody titers was useful for supporting diagnosis of Guillain-Barré syndrome, IgG anti-GQ1b antibody was detected in patients who had paresis of extraocular muscles in Fisher's syndrome, Guillain-Barré syndrome, Bickerstaff's brainstem encephalitis, and acute ophthalmoparesis. This study showed that the measurement for anti-GM1 and anti-GQ1b antibodies are very useful. SN - 0006-8969 UR - https://www.unboundmedicine.com/medline/citation/9789308/[Clinical_utility_of_measurement_for_anti_GM1_and_anti_GQ1b_antibodies]_ DB - PRIME DP - Unbound Medicine ER -