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Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal.
Am J Trop Med Hyg. 1998 Oct; 59(4):582-90.AJ

Abstract

We have examined 83 inhabitants of Asar village in eastern Sudan, where malaria transmission lasts approximately 2-3 months each year, for the presence of Plasmodium falciparum during the prolonged dry season. All patients were treated with a standard dose of chloroquine following the first diagnosis, then examined by microscopy and the polymerase chain reaction (PCR) every two weeks for the first two months and subsequently once each month for the next 15 months throughout the dry season until the following transmission season. The PCR primers used amplified polymorphic regions of the merozoite surface protein-1 (MSP-1), MSP-2, and glutamate-rich protein genes. Results show that subpatent and asymptomatic parasitemias persisted in some patients for several months throughout the dry season, often as genetically complex infections. Different genotypes could coexist together in a single infection and the proportions of each could fluctuate dramatically during this period. However, in some individuals, single genotypes appeared to persist for several months. Reappearance of clinical symptoms among patients with chronic infections was often associated with appearance of new alleles, indicating reinfections with parasites of novel genotypes.

Authors+Show Affiliations

Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9790434

Citation

Babiker, H A., et al. "Characteristics of Plasmodium Falciparum Parasites That Survive the Lengthy Dry Season in Eastern Sudan Where Malaria Transmission Is Markedly Seasonal." The American Journal of Tropical Medicine and Hygiene, vol. 59, no. 4, 1998, pp. 582-90.
Babiker HA, Abdel-Muhsin AM, Ranford-Cartwright LC, et al. Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal. Am J Trop Med Hyg. 1998;59(4):582-90.
Babiker, H. A., Abdel-Muhsin, A. M., Ranford-Cartwright, L. C., Satti, G., & Walliker, D. (1998). Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal. The American Journal of Tropical Medicine and Hygiene, 59(4), 582-90.
Babiker HA, et al. Characteristics of Plasmodium Falciparum Parasites That Survive the Lengthy Dry Season in Eastern Sudan Where Malaria Transmission Is Markedly Seasonal. Am J Trop Med Hyg. 1998;59(4):582-90. PubMed PMID: 9790434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal. AU - Babiker,H A, AU - Abdel-Muhsin,A M, AU - Ranford-Cartwright,L C, AU - Satti,G, AU - Walliker,D, PY - 1998/10/28/pubmed PY - 1998/10/28/medline PY - 1998/10/28/entrez SP - 582 EP - 90 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 59 IS - 4 N2 - We have examined 83 inhabitants of Asar village in eastern Sudan, where malaria transmission lasts approximately 2-3 months each year, for the presence of Plasmodium falciparum during the prolonged dry season. All patients were treated with a standard dose of chloroquine following the first diagnosis, then examined by microscopy and the polymerase chain reaction (PCR) every two weeks for the first two months and subsequently once each month for the next 15 months throughout the dry season until the following transmission season. The PCR primers used amplified polymorphic regions of the merozoite surface protein-1 (MSP-1), MSP-2, and glutamate-rich protein genes. Results show that subpatent and asymptomatic parasitemias persisted in some patients for several months throughout the dry season, often as genetically complex infections. Different genotypes could coexist together in a single infection and the proportions of each could fluctuate dramatically during this period. However, in some individuals, single genotypes appeared to persist for several months. Reappearance of clinical symptoms among patients with chronic infections was often associated with appearance of new alleles, indicating reinfections with parasites of novel genotypes. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/9790434/Characteristics_of_Plasmodium_falciparum_parasites_that_survive_the_lengthy_dry_season_in_eastern_Sudan_where_malaria_transmission_is_markedly_seasonal_ L2 - http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=9790434 DB - PRIME DP - Unbound Medicine ER -