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The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus.
Free Radic Res. 1998 Aug; 29(2):137-41.FR

Abstract

Oxidation of low-density lipoprotein (LDL) may be an important factor in the development of diabetic macrovascular and renal complications. The level of autoantibodies against oxidized LDL (oxLDL-Ab) can be used as an index of LDL oxidation in vivo. The purpose of this study was to investigate the association between the level of oxLDL-Ab and the presence of coronary heart disease and renal dysfunction in patients with non-insulin-dependent diabetes mellitus (NIDDM). We determined the plasma levels of oxLDL-Ab in 46 NIDDM patients and 48 well matched nondiabetic control subjects. NIDDM patients had a moderately higher level of oxLDL-Ab than control subjects (0.083 +/- 0.051 vs. 0.062 +/- 0.045, p = 0.04). However, there was no difference in the level of oxLDL-Ab between subjects with and without coronary heart disease, and the level of oxLDL-Ab was not associated with indices of glomerular filtration rate or urinary albumin excretion.

Authors+Show Affiliations

Medical School, University of Tampere, and Department of Clinical Chemistry, Tampere University Hospital, Finland. bljale@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9790515

Citation

Leinonen, J S., et al. "The Level of Autoantibodies Against Oxidized LDL Is Not Associated With the Presence of Coronary Heart Disease or Diabetic Kidney Disease in Patients With Non-insulin-dependent Diabetes Mellitus." Free Radical Research, vol. 29, no. 2, 1998, pp. 137-41.
Leinonen JS, Rantalaiho V, Laippala P, et al. The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus. Free Radic Res. 1998;29(2):137-41.
Leinonen, J. S., Rantalaiho, V., Laippala, P., Wirta, O., Pasternack, A., Alho, H., Jaakkola, O., Ylä-Herttuala, S., Koivula, T., & Lehtimäki, T. (1998). The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus. Free Radical Research, 29(2), 137-41.
Leinonen JS, et al. The Level of Autoantibodies Against Oxidized LDL Is Not Associated With the Presence of Coronary Heart Disease or Diabetic Kidney Disease in Patients With Non-insulin-dependent Diabetes Mellitus. Free Radic Res. 1998;29(2):137-41. PubMed PMID: 9790515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus. AU - Leinonen,J S, AU - Rantalaiho,V, AU - Laippala,P, AU - Wirta,O, AU - Pasternack,A, AU - Alho,H, AU - Jaakkola,O, AU - Ylä-Herttuala,S, AU - Koivula,T, AU - Lehtimäki,T, PY - 1998/10/28/pubmed PY - 1998/10/28/medline PY - 1998/10/28/entrez SP - 137 EP - 41 JF - Free radical research JO - Free Radic. Res. VL - 29 IS - 2 N2 - Oxidation of low-density lipoprotein (LDL) may be an important factor in the development of diabetic macrovascular and renal complications. The level of autoantibodies against oxidized LDL (oxLDL-Ab) can be used as an index of LDL oxidation in vivo. The purpose of this study was to investigate the association between the level of oxLDL-Ab and the presence of coronary heart disease and renal dysfunction in patients with non-insulin-dependent diabetes mellitus (NIDDM). We determined the plasma levels of oxLDL-Ab in 46 NIDDM patients and 48 well matched nondiabetic control subjects. NIDDM patients had a moderately higher level of oxLDL-Ab than control subjects (0.083 +/- 0.051 vs. 0.062 +/- 0.045, p = 0.04). However, there was no difference in the level of oxLDL-Ab between subjects with and without coronary heart disease, and the level of oxLDL-Ab was not associated with indices of glomerular filtration rate or urinary albumin excretion. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/9790515/The_level_of_autoantibodies_against_oxidized_LDL_is_not_associated_with_the_presence_of_coronary_heart_disease_or_diabetic_kidney_disease_in_patients_with_non_insulin_dependent_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -