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Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex.
Am J Physiol. 1998 11; 275(5):R1611-9.AJ

Abstract

The object of the current study was to determine if ANG II acts at type 1 (AT1) or type 2 (AT2) receptors in the nucleus of the solitary tract (NTS) to reduce baroreceptor reflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR). Experiments were carried out in urethan-anesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Reflex changes in RSNA and HR were elicited by intravenous infusion of either phenylephrine or sodium nitroprusside before and after bilateral microinjection of CV-11974 (AT1 receptor antagonist, 10 pmol), PD-123319 (AT2 receptor antagonist, 100 pmol), or artificial cerebrospinal fluid (aCSF, 50 nl) in the NTS. Mean arterial pressure (MAP)-RSNA and MAP-HR data were fit to logistic functions to analyze the baroreceptor reflex. Baroreceptor reflex sensitivities for RSNA and HR were attenuated in SHR compared with those in WKY rats. Bilateral injection of CV-11974, PD-123319, or aCSF in the NTS of either strain had no effect on baseline arterial pressure, HR, or RSNA. However, CV-11974 injected in the NTS increased significantly (P < 0.01) the sensitivities for baroreceptor reflex control of RSNA and HR in SHR and WKY rats. Neither PD-123319 nor aCSF altered baroreceptor reflex control of RSNA and HR in either SHR or WKY rats. These results demonstrate that endogenous ANG II acts at AT1 receptors of the NTS to attenuate the baroreceptor reflex in SHR as well as in WKY rats.

Authors+Show Affiliations

Hypertension Center, Division of Surgical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9791081

Citation

Matsumura, K, et al. "Angiotensin II Acts at AT1 Receptors in the Nucleus of the Solitary Tract to Attenuate the Baroreceptor Reflex." The American Journal of Physiology, vol. 275, no. 5, 1998, pp. R1611-9.
Matsumura K, Averill DB, Ferrario CM. Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex. Am J Physiol. 1998;275(5):R1611-9.
Matsumura, K., Averill, D. B., & Ferrario, C. M. (1998). Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex. The American Journal of Physiology, 275(5), R1611-9. https://doi.org/10.1152/ajpregu.1998.275.5.R1611
Matsumura K, Averill DB, Ferrario CM. Angiotensin II Acts at AT1 Receptors in the Nucleus of the Solitary Tract to Attenuate the Baroreceptor Reflex. Am J Physiol. 1998;275(5):R1611-9. PubMed PMID: 9791081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex. AU - Matsumura,K, AU - Averill,D B, AU - Ferrario,C M, PY - 1998/10/29/pubmed PY - 1998/10/29/medline PY - 1998/10/29/entrez SP - R1611 EP - 9 JF - The American journal of physiology JO - Am. J. Physiol. VL - 275 IS - 5 N2 - The object of the current study was to determine if ANG II acts at type 1 (AT1) or type 2 (AT2) receptors in the nucleus of the solitary tract (NTS) to reduce baroreceptor reflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR). Experiments were carried out in urethan-anesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Reflex changes in RSNA and HR were elicited by intravenous infusion of either phenylephrine or sodium nitroprusside before and after bilateral microinjection of CV-11974 (AT1 receptor antagonist, 10 pmol), PD-123319 (AT2 receptor antagonist, 100 pmol), or artificial cerebrospinal fluid (aCSF, 50 nl) in the NTS. Mean arterial pressure (MAP)-RSNA and MAP-HR data were fit to logistic functions to analyze the baroreceptor reflex. Baroreceptor reflex sensitivities for RSNA and HR were attenuated in SHR compared with those in WKY rats. Bilateral injection of CV-11974, PD-123319, or aCSF in the NTS of either strain had no effect on baseline arterial pressure, HR, or RSNA. However, CV-11974 injected in the NTS increased significantly (P < 0.01) the sensitivities for baroreceptor reflex control of RSNA and HR in SHR and WKY rats. Neither PD-123319 nor aCSF altered baroreceptor reflex control of RSNA and HR in either SHR or WKY rats. These results demonstrate that endogenous ANG II acts at AT1 receptors of the NTS to attenuate the baroreceptor reflex in SHR as well as in WKY rats. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/9791081/Angiotensin_II_acts_at_AT1_receptors_in_the_nucleus_of_the_solitary_tract_to_attenuate_the_baroreceptor_reflex_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.1998.275.5.R1611?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -